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学科主题: 临床医学
题名:
Silent myocardial ischemia detected by single photon emission computed tomography (SPECT) and risk of cardiac events among asymptomatic patients with type 2 diabetes: A meta-analysis of prospective studies
作者: Zhang, Lihua1,2; Li, Hong3; Zhang, Simin1; Jaacks, Lindsay M.4; Li, Yufeng1; Ji, Linong1
关键词: Type 2 diabetes ; Silent myocardial ischemia ; Single photon emission computed tomography (SPECT) ; Meta-analysis
刊名: JOURNAL OF DIABETES AND ITS COMPLICATIONS
发表日期: 2014-05-01
DOI: 10.1016/j.jdiacomp.2013.11.013
卷: 28, 期:3, 页:413-418
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: CORONARY-ARTERY-DISEASE ; PROGNOSTIC VALUE ; FOLLOW-UP ; SCINTIGRAPHY ; DIAD ; ECHOCARDIOGRAPHY ; PREVALENCE ; PREVENTION ; PREDICTION ; MELLITUS
英文摘要:

Objective: To assess the value of detecting silent myocardial ischemia (SMI) by single photon emission computed tomography (SPECT) in predicting risk of cardiac events among patients with type 2 diabetes mellitus (T2DM) who do not have overt cardiac symptoms.

Materials and Methods: Electronic databases (PubMed, Cochrane Library, EMBASE, and others) and original article references were systematically searched through February 1, 2013. A fixed-effects model was applied to pooled data to estimate relative risks (RR) and 95% confidence intervals (CI).

Results: Ten prospective studies with follow-up ranging from 1 to 6 years were identified. Among the total of 1360 asymptomatic patients with T2DM screened by SPECT the cumulative prevalence rate of SMI was 26.1%. Patients with SMI were at increased risk of experiencing endpoints relative to patients without SMI: RR (95% CI) for cardiac death, 4.60 (1.78-11.84); non-fatal cardiac events, 3.48 (2.30-5.28); total cardiac events, 3.48 (2.59-4.68); and all-cause mortality, 2.20(1.14-4.25). The risk of cardiac death and non-fatal cardiac events increased with increasing severity of SPECT-detected abnormalities.

Conclusions: SMI detected by SPECT is associated with increased risk of cardiac death, all-cause mortality, and non-fatal cardiac events in T2DM patients without overt cardiac symptoms. Advanced intervention procedures including intensive drug management should be implemented to reduce the risk of cardiac events for SMI-positive T2DM patients. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2012AA02A509 ; D090507046410012 ; 2011CB504001
项目资助者: China National High Technology Research and Development Program (863 program) ; Beijing Science &amp ; Technology Committee ; National Basic Research Program of China
WOS记录号: WOS:000335717800028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67322
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100871, Peoples R China
2.Kunming Med Univ, Affiliated Hosp 1, Dept Geriatr, Kunming, Peoples R China
3.Kunming Med Univ, Affiliated Hosp 1, Dept Endocrinol & Metab, Kunming, Peoples R China
4.Univ N Carolina, Dept Nutr, Chapel Hill, NC USA

Recommended Citation:
Zhang, Lihua,Li, Hong,Zhang, Simin,et al. Silent myocardial ischemia detected by single photon emission computed tomography (SPECT) and risk of cardiac events among asymptomatic patients with type 2 diabetes: A meta-analysis of prospective studies[J]. JOURNAL OF DIABETES AND ITS COMPLICATIONS,2014,28(3):413-418.
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