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学科主题临床医学
Quantification of Gd-DTPA concentration in neuroimaging using T-1 3D MP-RAGE sequence at 3.0 T
Xua, Fangjingwei1; Han, Hongbin1; Zhang, Hailong2,3; Pi, Jincai; Fu, Yu4
关键词Gd-DTPA Concentration quantification Neuroimaging 3D MP-RAGE
刊名MAGNETIC RESONANCE IMAGING
2011-07-01
DOI10.1016/j.mri.2011.02.019
29期:6页:827-834
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]CONTRAST-ENHANCED MRI ; QUANTITATIVE ASSESSMENT ; IMAGES ; TISSUE
英文摘要

Purpose: To propose a simple and accurate quantitative method based on the linear relationship between magnetic resonance (MR) signal enhancement (Delta SI=SIpostcontrast-SIprecontrast) and gadolinium-diethylcnetriaminepentaacetic acid (Gd-DTPA) concentration (C) by using T-1-weighted three-dimensional magnetization-prepared rapid acquisition gradient-echo (T-1 3D MP-RAGE) sequence for the in vivo measurement of Gd-DTPA concentration in real-time neuroimaging at 3.0 T.

Methods: Phantom experiment was carried out to study the linear fitting of signal intensity change vs. Gd-DTPA concentration (Delta SI-C) curve. A goodness-of-fit test was performed to compare the accuracy between the proposed method and the conventional method based on longitudinal relaxation rate (R-1=1/T-1) measurement. The influences on the goodness of fit (R-2) and the signal-to-noise ratio (SNR) by sequence parameters were explored. Six human subjects with different brain tumors, who underwent a Gd-DTPA-enhanced MRI, were enrolled for in vivo application of the novel method.

Results: A good linear relationship between Delta SI and Gd-DTPA concentration existed over the concentration range of 0-1 mM (R-2=0.985). The linearity of the Delta SI-C curve was as good as that of the 1/T-1-C curve (R-2=0.988). Concentrations calculated by both methods had a strong correlation (R-2=0.920). An improved linearity of the Delta SI-C curve and an increased SNR can be achieved using sequences with a shorter inversion time (TI) and a higher flip angle. The concentration range of Gd-DTPA in human brain tumors was within the quantitative scope of 0-1 mM.

Conclusions: The proposed quantitative method based on Delta SI measurement is accurate and applicable for real-time neuroimaging at 3.0 T. (C) 2011 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000292358800009
项目编号NCET-05-0019 ; 30972811 ; 7093137
资助机构University of China ; National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67325
专题北京大学第三临床医学院_放射科
北京大学第三临床医学院_神经内科
作者单位1.Peking Univ, Dept Radiol, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Sports Med, Hosp 3, Beijing 100191, Peoples R China
3.Hong Kong Univ Sci & Technol, Dept Biol, Hong Kong, Hong Kong, Peoples R China
4.Peking Univ, Dept Neurol, Hosp 3, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Xua, Fangjingwei,Han, Hongbin,Zhang, Hailong,et al. Quantification of Gd-DTPA concentration in neuroimaging using T-1 3D MP-RAGE sequence at 3.0 T[J]. MAGNETIC RESONANCE IMAGING,2011,29(6):827-834.
APA Xua, Fangjingwei,Han, Hongbin,Zhang, Hailong,Pi, Jincai,&Fu, Yu.(2011).Quantification of Gd-DTPA concentration in neuroimaging using T-1 3D MP-RAGE sequence at 3.0 T.MAGNETIC RESONANCE IMAGING,29(6),827-834.
MLA Xua, Fangjingwei,et al."Quantification of Gd-DTPA concentration in neuroimaging using T-1 3D MP-RAGE sequence at 3.0 T".MAGNETIC RESONANCE IMAGING 29.6(2011):827-834.
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