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学科主题: 临床医学
题名:
Quantification of Gd-DTPA concentration in neuroimaging using T-1 3D MP-RAGE sequence at 3.0 T
作者: Xua, Fangjingwei1; Han, Hongbin1; Zhang, Hailong2,3; Pi, Jincai; Fu, Yu4
关键词: Gd-DTPA ; Concentration quantification ; Neuroimaging ; 3D MP-RAGE
刊名: MAGNETIC RESONANCE IMAGING
发表日期: 2011-07-01
DOI: 10.1016/j.mri.2011.02.019
卷: 29, 期:6, 页:827-834
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: CONTRAST-ENHANCED MRI ; QUANTITATIVE ASSESSMENT ; IMAGES ; TISSUE
英文摘要:

Purpose: To propose a simple and accurate quantitative method based on the linear relationship between magnetic resonance (MR) signal enhancement (Delta SI=SIpostcontrast-SIprecontrast) and gadolinium-diethylcnetriaminepentaacetic acid (Gd-DTPA) concentration (C) by using T-1-weighted three-dimensional magnetization-prepared rapid acquisition gradient-echo (T-1 3D MP-RAGE) sequence for the in vivo measurement of Gd-DTPA concentration in real-time neuroimaging at 3.0 T.

Methods: Phantom experiment was carried out to study the linear fitting of signal intensity change vs. Gd-DTPA concentration (Delta SI-C) curve. A goodness-of-fit test was performed to compare the accuracy between the proposed method and the conventional method based on longitudinal relaxation rate (R-1=1/T-1) measurement. The influences on the goodness of fit (R-2) and the signal-to-noise ratio (SNR) by sequence parameters were explored. Six human subjects with different brain tumors, who underwent a Gd-DTPA-enhanced MRI, were enrolled for in vivo application of the novel method.

Results: A good linear relationship between Delta SI and Gd-DTPA concentration existed over the concentration range of 0-1 mM (R-2=0.985). The linearity of the Delta SI-C curve was as good as that of the 1/T-1-C curve (R-2=0.988). Concentrations calculated by both methods had a strong correlation (R-2=0.920). An improved linearity of the Delta SI-C curve and an increased SNR can be achieved using sequences with a shorter inversion time (TI) and a higher flip angle. The concentration range of Gd-DTPA in human brain tumors was within the quantitative scope of 0-1 mM.

Conclusions: The proposed quantitative method based on Delta SI measurement is accurate and applicable for real-time neuroimaging at 3.0 T. (C) 2011 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: NCET-05-0019 ; 30972811 ; 7093137
项目资助者: University of China ; National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation
WOS记录号: WOS:000292358800009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67325
Appears in Collections:北京大学第三临床医学院_放射科_期刊论文

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作者单位: 1.Peking Univ, Dept Radiol, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Sports Med, Hosp 3, Beijing 100191, Peoples R China
3.Hong Kong Univ Sci & Technol, Dept Biol, Hong Kong, Hong Kong, Peoples R China
4.Peking Univ, Dept Neurol, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Xua, Fangjingwei,Han, Hongbin,Zhang, Hailong,et al. Quantification of Gd-DTPA concentration in neuroimaging using T-1 3D MP-RAGE sequence at 3.0 T[J]. MAGNETIC RESONANCE IMAGING,2011,29(6):827-834.
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