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学科主题临床医学
IL-37 inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells of patients with systemic lupus erythematosus: its correlation with disease activity
Ye, Liang1,2,3; Ji, Ling4; Wen, Zhongyang1,2,3; Zhou, Yanfei1,3; Hu, Dongsheng5; Li, Yanqun1,2,3; Yu, Ting1,2,3; Chen, Bingni1,2,3; Zhang, Jinshun1,2,3; Ding, Liping1,2,3; Du, Jing4; Huang, Zhong1,2,3
关键词Interleukin-37 Systemic lupus erythematosus Autoimmunity Cytokines Peripheral blood mononuclear cell
刊名JOURNAL OF TRANSLATIONAL MEDICINE
2014-03-16
DOI10.1186/1479-5876-12-69
12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
资助者National Natural Science Foundation of China ; Basic Research Program of Science and Technology Plan of Shenzhen ; Special Program of Construction National Innovative City of Shenzhen ; National Natural Science Foundation of China ; Basic Research Program of Science and Technology Plan of Shenzhen ; Special Program of Construction National Innovative City of Shenzhen
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]EXPRESSION ; EFFICACY ; SAFETY ; INTERLEUKIN-37 ; NEPHRITIS ; ARTHRITIS ; PROTECTS ; FAMILY ; INJURY ; MICE
英文摘要

Background: Interleukin-37 (IL-37), a new member of IL-1 family cytokine, is recently identified as a natural inhibitor of innate immunity. This study aimed to measure the peripheral blood mononuclear cells (PBMCs) and serum levels of IL-37 in patients with systemic lupus erythematosus (SLE) and to investigate its role in SLE, including its correlation with disease activity, organ disorder and the regulation of inflammatory cytokines.

Methods: The expressions of IL-37 mRNAs in PBMCs and serum IL-37 levels in 66 SLE patients were measured by real-time polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). SLE patients PBMCs were stimulated with recombinant IL-37, levels of cytokines TNF-alpha, IL-1 beta, IL-6 and IL-10 were detected by RT-PCR and ELISA.

Results: IL-37 mRNAs and serum protein levels were higher in patients with SLE compared with healthy controls. Patients with active disease showed higher IL-37 mRNAs and serum protein levels compared with those with inactive disease as well as healthy controls. Serum IL-37 levels correlated with SLEDAI and inversely with C3 and C4. Serum IL-37 levels were higher in SLE patients with renal involvement compared with those without renal disease. In vitro, IL-37 inhibited the production of TNF-alpha, IL-1 beta and IL-6 in PBMCs of patients with SLE, whereas the production of IL-10 was unaffected.

Conclusions: IL-37 associated with SLE disease activity, especially related with SLE renal disease activity. IL-37 is an important cytokine in the control of SLE pathogenesis by suppressing the production of inflammatory cytokines. Thus, IL-37 may provide a novel research target for the pathogenesis and therapy of SLE.

语种英语
所属项目编号81273305 ; JC201005280578A ; 301201003010
资助者National Natural Science Foundation of China ; Basic Research Program of Science and Technology Plan of Shenzhen ; Special Program of Construction National Innovative City of Shenzhen ; National Natural Science Foundation of China ; Basic Research Program of Science and Technology Plan of Shenzhen ; Special Program of Construction National Innovative City of Shenzhen
WOS记录号WOS:000335535500001
Citation statistics
Cited Times:55[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67328
Collection北京大学深圳医院
作者单位1.Shenzhen Univ, Sch Med, Biol Therapy Inst, Shenzhen 518060, Peoples R China
2.Shenzhen Univ, Sch Med, Dept Pathogen Biol & Immunol, Shenzhen 518060, Peoples R China
3.Shenzhen City Shenzhen Univ, Immunodiagnost Technol Platforms, Shenzhen 518060, Peoples R China
4.Peking Univ, Dept Lab Med, Shenzhen Hosp, Shenzhen 518036, Peoples R China
5.Shenzhen Univ, Sch Med, Dept Prevent Med, Shenzhen 518060, Peoples R China
Recommended Citation
GB/T 7714
Ye, Liang,Ji, Ling,Wen, Zhongyang,et al. IL-37 inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells of patients with systemic lupus erythematosus: its correlation with disease activity[J]. JOURNAL OF TRANSLATIONAL MEDICINE,2014,12.
APA Ye, Liang.,Ji, Ling.,Wen, Zhongyang.,Zhou, Yanfei.,Hu, Dongsheng.,...&Huang, Zhong.(2014).IL-37 inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells of patients with systemic lupus erythematosus: its correlation with disease activity.JOURNAL OF TRANSLATIONAL MEDICINE,12.
MLA Ye, Liang,et al."IL-37 inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells of patients with systemic lupus erythematosus: its correlation with disease activity".JOURNAL OF TRANSLATIONAL MEDICINE 12(2014).
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