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Outcome of hepatitis C virus infection in Chinese paid plasma donors: A 12-19-year cohort study
Rao, Hui-Ying1,2; Sun, De-Gui; Yang, Rui-Feng1,2; Liu, Feng1,2; Wang, Jian1; Feng, Bo1,2; Wu, Nan1; Fang, Ji-Lian1; Song, Guang-Jun1; Ma, Hui1,2; Guo, Fang1,2; Wang, Jiang-Hua1,2; Li, Xiao-Bo1; Jin, Qian1,2; Qin, Hong1; Zhuang, Hui3; Wei, Lai1,2
关键词hepatitis C virus outcome plasma donor
刊名JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2012-03-01
DOI10.1111/j.1440-1746.2011.06880.x
27期:3页:526-532
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]SINGLE-SOURCE OUTBREAK ; LONG-TERM MORTALITY ; FIBROSIS PROGRESSION ; NATURAL-HISTORY ; LIVER-DISEASE ; ALCOHOL-USE ; NON-A ; NON-B ; MANAGEMENT ; MORBIDITY
英文摘要

Background and Aims: Commercial plasma donation was introduced in China in the 1970s. Cases of non-A, non-B hepatitis (hepatitis C) continued to occur, with multiple outbreaks among plasma donors in Guan county, Hebei province between 1972 and 1990. The outcomes of hepatitis C virus (HCV) infection in these paid plasma donors from six villages of Guan county were followed up for 1219 years.

Methods: A total of 402 plasma donors with HCV infection were enrolled since antiHCV- positive in 1991 or 1998. Follow up was maintained until death or the end of the observation period. No antiviral treatment was applied during the period of infection.

Results: Follow up was lost in 23 cases. After a 12-19-year follow up, 31 donors died, with the cause of death directly related to liver disease in 15 cases, and an overall mortality of 8.18% (31/379). The incidence of liver cirrhosis was 10.03%, and hepatocellular carcinoma (HCC) was 2.90%. The rate of viral spontaneous clearing was 20.32% (77/379), and 13.69% (23/168) in males and 25.59% (54/211) in females. In May 2010, detections were performed in 348 cases. Abnormality of liver function was related to HCV viremia. Sex and alcohol intake impacted the outcome of HCV infection. There was no correlation between the viral spontaneous clearance with age of infection and genotype.

Conclusions: This area has a high rate of chronicity in HCV infection due to plasma donation. Twenty-five years after virus infection, liver cirrhosis or HCC developed in one-tenth of patients, with an overall mortality of 8.18%.

语种英语
WOS记录号WOS:000300690600020
项目编号2008ZX10002-013 ; 2008ZX10002-012 ; 2005CB522902 ; 2007CB512900 ; 2006AA02A410 ; 30800508
资助机构National S&amp ; T Major Project for Infectious Diseases Control ; Major State Basic Research Development Program of China ; National High-Tech R&amp ; D Program of China ; National Natural Science Foundation of China
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67329
专题北京大学第二临床医学院_肝病科
北京大学基础医学院
北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing Key Lab Hepatitis & Immunotherapy Liver D, Beijing 100044, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Univ Michigan Hlth Syst, Joint Inst Translat & Clin Res, Beijing 100044, Peoples R China
3.Peking Univ, Dept Microbiol, Hlth Sci Ctr, Beijing 100044, Peoples R China
4.Guan Cty Ctr Dis Control & Prevent, Hebei Guan, Peoples R China
推荐引用方式
GB/T 7714
Rao, Hui-Ying,Sun, De-Gui,Yang, Rui-Feng,et al. Outcome of hepatitis C virus infection in Chinese paid plasma donors: A 12-19-year cohort study[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2012,27(3):526-532.
APA Rao, Hui-Ying.,Sun, De-Gui.,Yang, Rui-Feng.,Liu, Feng.,Wang, Jian.,...&Wei, Lai.(2012).Outcome of hepatitis C virus infection in Chinese paid plasma donors: A 12-19-year cohort study.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,27(3),526-532.
MLA Rao, Hui-Ying,et al."Outcome of hepatitis C virus infection in Chinese paid plasma donors: A 12-19-year cohort study".JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 27.3(2012):526-532.
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