|Outcome of hepatitis C virus infection in Chinese paid plasma donors: A 12-19-year cohort study|
|Rao, Hui-Ying1,2; Sun, De-Gui; Yang, Rui-Feng1,2; Liu, Feng1,2; Wang, Jian1; Feng, Bo1,2; Wu, Nan1; Fang, Ji-Lian1; Song, Guang-Jun1; Ma, Hui1,2; Guo, Fang1,2; Wang, Jiang-Hua1,2; Li, Xiao-Bo1; Jin, Qian1,2; Qin, Hong1; Zhuang, Hui3; Wei, Lai1,2|
|关键词||hepatitis C virus outcome plasma donor|
|刊名||JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Gastroenterology & Hepatology|
|研究领域[WOS]||Gastroenterology & Hepatology|
|关键词[WOS]||SINGLE-SOURCE OUTBREAK ; LONG-TERM MORTALITY ; FIBROSIS PROGRESSION ; NATURAL-HISTORY ; LIVER-DISEASE ; ALCOHOL-USE ; NON-A ; NON-B ; MANAGEMENT ; MORBIDITY|
Background and Aims: Commercial plasma donation was introduced in China in the 1970s. Cases of non-A, non-B hepatitis (hepatitis C) continued to occur, with multiple outbreaks among plasma donors in Guan county, Hebei province between 1972 and 1990. The outcomes of hepatitis C virus (HCV) infection in these paid plasma donors from six villages of Guan county were followed up for 1219 years.
Methods: A total of 402 plasma donors with HCV infection were enrolled since antiHCV- positive in 1991 or 1998. Follow up was maintained until death or the end of the observation period. No antiviral treatment was applied during the period of infection.
Results: Follow up was lost in 23 cases. After a 12-19-year follow up, 31 donors died, with the cause of death directly related to liver disease in 15 cases, and an overall mortality of 8.18% (31/379). The incidence of liver cirrhosis was 10.03%, and hepatocellular carcinoma (HCC) was 2.90%. The rate of viral spontaneous clearing was 20.32% (77/379), and 13.69% (23/168) in males and 25.59% (54/211) in females. In May 2010, detections were performed in 348 cases. Abnormality of liver function was related to HCV viremia. Sex and alcohol intake impacted the outcome of HCV infection. There was no correlation between the viral spontaneous clearance with age of infection and genotype.
Conclusions: This area has a high rate of chronicity in HCV infection due to plasma donation. Twenty-five years after virus infection, liver cirrhosis or HCC developed in one-tenth of patients, with an overall mortality of 8.18%.
|项目编号||2008ZX10002-013 ; 2008ZX10002-012 ; 2005CB522902 ; 2007CB512900 ; 2006AA02A410 ; 30800508|
|资助机构||National S& ; T Major Project for Infectious Diseases Control ; Major State Basic Research Development Program of China ; National High-Tech R& ; D Program of China ; National Natural Science Foundation of China|
|作者单位||1.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing Key Lab Hepatitis & Immunotherapy Liver D, Beijing 100044, Peoples R China|
2.Peking Univ, Hlth Sci Ctr, Univ Michigan Hlth Syst, Joint Inst Translat & Clin Res, Beijing 100044, Peoples R China
3.Peking Univ, Dept Microbiol, Hlth Sci Ctr, Beijing 100044, Peoples R China
4.Guan Cty Ctr Dis Control & Prevent, Hebei Guan, Peoples R China
|Rao, Hui-Ying,Sun, De-Gui,Yang, Rui-Feng,et al. Outcome of hepatitis C virus infection in Chinese paid plasma donors: A 12-19-year cohort study[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2012,27(3):526-532.|
|APA||Rao, Hui-Ying.,Sun, De-Gui.,Yang, Rui-Feng.,Liu, Feng.,Wang, Jian.,...&Wei, Lai.(2012).Outcome of hepatitis C virus infection in Chinese paid plasma donors: A 12-19-year cohort study.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,27(3),526-532.|
|MLA||Rao, Hui-Ying,et al."Outcome of hepatitis C virus infection in Chinese paid plasma donors: A 12-19-year cohort study".JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 27.3(2012):526-532.|