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学科主题临床医学
Integration of statistical inference methods and a novel control measure to improve sensitivity and specificity of data analysis in expression profiling studies
Zang, Shizhu; Guo, Ruifang; Zhang, Liang; Lu, Youyong
关键词microarray gastric cancer gene expression profiling SAM BAGEL
刊名JOURNAL OF BIOMEDICAL INFORMATICS
2007-10-01
DOI10.1016/j.jbi.2007.01.002
40期:5页:552-560
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Computer Science, Interdisciplinary Applications ; Medical Informatics
研究领域[WOS]Computer Science ; Medical Informatics
关键词[WOS]MICROARRAY DATA ; GENE-EXPRESSION ; DIFFERENTIAL EXPRESSION ; CLUSTER-ANALYSIS ; PLATFORMS ; MODELS ; CELLS
英文摘要

Statistical methods have proven invaluable tools for enhancing the quality of microarray analysis. In this study, we used different methods such as significance analysis of microarrays (SAM) and Bayesian analysis of gene expression levels (BAGEL), to analyze the same set of raw data in an attempt to maximize the chance of identifying genes whose expression were significantly altered in gastric cancers. In addition, we examined the utility of an additional set of reference in controlling the variances and enhancing the quality of the results. Our results showed that BAGEL has the advantage of detecting small yet statistically significant differences, which might be of biological significance. Furthermore, introducing an additional control into the BAGEL, we were able to minimize the influence of the variances and significantly reduce number of potential false positive hits. BAGEL incorporates a novel control significantly improve the sensitivity and specificity of gene expression profiling analysis. (c) 2007 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000249876200009
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67335
专题北京大学临床肿瘤学院
作者单位1.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Beijing Mol Oncol Lab, Beijing 100036, Peoples R China
2.Tsing Hua Univ, Sch Med, Natl Engn Res Ctr Beijing Biochip Technol, Beijing 102206, Peoples R China
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GB/T 7714
Zang, Shizhu,Guo, Ruifang,Zhang, Liang,et al. Integration of statistical inference methods and a novel control measure to improve sensitivity and specificity of data analysis in expression profiling studies[J]. JOURNAL OF BIOMEDICAL INFORMATICS,2007,40(5):552-560.
APA Zang, Shizhu,Guo, Ruifang,Zhang, Liang,&Lu, Youyong.(2007).Integration of statistical inference methods and a novel control measure to improve sensitivity and specificity of data analysis in expression profiling studies.JOURNAL OF BIOMEDICAL INFORMATICS,40(5),552-560.
MLA Zang, Shizhu,et al."Integration of statistical inference methods and a novel control measure to improve sensitivity and specificity of data analysis in expression profiling studies".JOURNAL OF BIOMEDICAL INFORMATICS 40.5(2007):552-560.
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