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学科主题: 基础医学
题名:
Differential modulation of nociceptive neural responses in medial and lateral pain pathways by peripheral electrical stimulation: a multichannel recording study
作者: Wang, JY; Zhang, HT; Han, JS; Chang, JY; Woodward, DJ; Luo, F
关键词: antinociception ; descending inhibition ; microelectrode ; pain ; rat
刊名: BRAIN RESEARCH
发表日期: 2004-07-16
DOI: 10.1016/j.brainres.2004.04.029
卷: 1014, 期:1-2, 页:197-208
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: POSITRON-EMISSION-TOMOGRAPHY ; OPIOID ANALGESIC REQUIREMENT ; ANTERIOR CINGULATE CORTEX ; LOW-BACK-PAIN ; PERIAQUEDUCTAL GRAY ; NERVE-STIMULATION ; DIFFERENT FREQUENCIES ; HUMAN-BRAIN ; ACUPOINT STIMULATION ; SOMATOSENSORY CORTEX
英文摘要:

It is well accepted that peripheral electrical stimulation (PES) can produce an analgesic effect in patients with acute and chronic pain. However, the neural basis underlying stimulation-induced analgesia remains unclear. In the present study, we examined the pain-related neural activity modified by peripheral stimulation in rats. The stimulation frequency of pulses applied to needle electrodes in the hindlimb was 2 Hz alternating with 100 Hz, with 0.6 ins pulse width for 2 Hz and 0.2 ins for 100 Hz. The intensity of the stimulation was increased stepwise from I to 3 mA with each 1-mA step lasting for 10 min. The nociceptive neural and behavioral responses were examined immediately after the termination of stimulation. Using a multiple-channel recording technique, we simultaneously recorded the activity of many single neurons located in the primary somatosensory and anterior cingulate cortex (ACC), as well as the ventral posterior and medial dorsal thalamus in behaving rats. Our results showed that peripheral electrical stimulation significantly reduced the nociceptive responses in ventroposterior thalamus and somatosensory cortex, indicating an inhibition of nociceptive processing. In contrast, the analgesic stimulation produced a significant increase in mediodorsal thalamus while a less significant decrease in cingulate cortex, reflecting a complicated effect associated with combined antinociceptive activation and nociceptive suppression. These results support the idea that peripheral electrical stimulation can ultimately alter the pain perception by specifically inhibiting the nociceptive transmission in the sensory pathway while mobilizing the antinociceptive action in the affective pathway, thus to produce pain relief. (C) 2004 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000222726700019
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67336
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Beijing 100083, Peoples R China
3.Wake Forest Univ, Hlth Sci Ctr, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA

Recommended Citation:
Wang, JY,Zhang, HT,Han, JS,et al. Differential modulation of nociceptive neural responses in medial and lateral pain pathways by peripheral electrical stimulation: a multichannel recording study[J]. BRAIN RESEARCH,2004,1014(1-2):197-208.
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