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学科主题: 临床医学
题名:
Immunofixation Electrophoresis Was Highly Specific for the Diagnosis of Renal Light-Chain Amyloidosis
作者: Zhou, Fu-de; Zhang, Lu-xia; Yao, Ying; Wang, Su-xia; Zou, Wan-zhong; Liu, Gang; Chen, Min1; Zhao, Ming-hui
关键词: Nephrotic ; Renal AL amyloidosis ; Immunofixation electrophoresis
刊名: AMERICAN JOURNAL OF THE MEDICAL SCIENCES
发表日期: 2013
DOI: 10.1097/MAJ.0b013e31824e0ec5
卷: 345, 期:1, 页:18-21
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: SINGLE CHINESE CENTER ; SPECTRUM ; SERUM
英文摘要:

Background: Renal light-chain amyloidosis (AL)(1) is one of the common causes of massive proteinuria and nephrotic syndrome, especially in elderly patients. This study aimed to evaluate the sensitivity and specificity of serum and urine using immunofixation electrophoresis (IFE) in the diagnosis of renal AL amyloidosis in patients older than 40 years. Methods: Patients receiving native renal biopsy in the hospital who meet the following criteria were recruited in this retrospective study: (1) proteinuria excretion >= 3.5 g/24 hr; (2) age >= 40 years when receiving renal biopsy and (3) biopsy-proven glomerulopathy. Serum and urine monoclonal free immunoglobulin light chains were detected using IFE. Results: A total of 625 patients were recruited. Of them, 32 patients (5.12%) were diagnosed as renal AL amyloidosis. The specificities of serum, urine and serum combined urine IFE in the total 625 patients (ie, monoclonal free immunoglobulin light chain in serum or urine) for diagnosis of renal AL amyloidosis were 98.6%, 98.0% and 97.6%, respectively. For patients older than 60 years, the specificities of serum, urine and serum combined urine IFE for diagnosis of renal AL amyloidosis were 98.5%, 98.0% and 97.6%, respectively and the sensitivity of serum, urine and serum combined urine IFE for diagnosis of renal AL amyloidosis were 68.6%, 81.3% and 81.3%, respectively. Conclusion: Serum or urine IFE was highly specific for renal AL amyloidosis for patients older than 40 years with nephrotic-range proteinuria. In older patients (>60 years), both the sensitivity and specificity of IFE for renal AL amyloidosis were high. Combination of serum and urine IFE could improve the sensitivity with comparable specificity.

语种: 英语
所属项目编号: 2012CB517702 ; 30972733 ; 81021004
项目资助者: Chinese 973 project ; National Natural Science Fund
WOS记录号: WOS:000312644000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67339
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China

Recommended Citation:
Zhou, Fu-de,Zhang, Lu-xia,Yao, Ying,et al. Immunofixation Electrophoresis Was Highly Specific for the Diagnosis of Renal Light-Chain Amyloidosis[J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES,2013,345(1):18-21.
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