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Immunofixation Electrophoresis Was Highly Specific for the Diagnosis of Renal Light-Chain Amyloidosis
Zhou, Fu-de; Zhang, Lu-xia; Yao, Ying; Wang, Su-xia; Zou, Wan-zhong; Liu, Gang; Chen, Min1; Zhao, Ming-hui
关键词Nephrotic Renal AL amyloidosis Immunofixation electrophoresis
刊名AMERICAN JOURNAL OF THE MEDICAL SCIENCES
2013
DOI10.1097/MAJ.0b013e31824e0ec5
345期:1页:18-21
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]SINGLE CHINESE CENTER ; SPECTRUM ; SERUM
英文摘要

Background: Renal light-chain amyloidosis (AL)(1) is one of the common causes of massive proteinuria and nephrotic syndrome, especially in elderly patients. This study aimed to evaluate the sensitivity and specificity of serum and urine using immunofixation electrophoresis (IFE) in the diagnosis of renal AL amyloidosis in patients older than 40 years. Methods: Patients receiving native renal biopsy in the hospital who meet the following criteria were recruited in this retrospective study: (1) proteinuria excretion >= 3.5 g/24 hr; (2) age >= 40 years when receiving renal biopsy and (3) biopsy-proven glomerulopathy. Serum and urine monoclonal free immunoglobulin light chains were detected using IFE. Results: A total of 625 patients were recruited. Of them, 32 patients (5.12%) were diagnosed as renal AL amyloidosis. The specificities of serum, urine and serum combined urine IFE in the total 625 patients (ie, monoclonal free immunoglobulin light chain in serum or urine) for diagnosis of renal AL amyloidosis were 98.6%, 98.0% and 97.6%, respectively. For patients older than 60 years, the specificities of serum, urine and serum combined urine IFE for diagnosis of renal AL amyloidosis were 98.5%, 98.0% and 97.6%, respectively and the sensitivity of serum, urine and serum combined urine IFE for diagnosis of renal AL amyloidosis were 68.6%, 81.3% and 81.3%, respectively. Conclusion: Serum or urine IFE was highly specific for renal AL amyloidosis for patients older than 40 years with nephrotic-range proteinuria. In older patients (>60 years), both the sensitivity and specificity of IFE for renal AL amyloidosis were high. Combination of serum and urine IFE could improve the sensitivity with comparable specificity.

语种英语
WOS记录号WOS:000312644000003
项目编号2012CB517702 ; 30972733 ; 81021004
资助机构Chinese 973 project ; National Natural Science Fund
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67339
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Fu-de,Zhang, Lu-xia,Yao, Ying,et al. Immunofixation Electrophoresis Was Highly Specific for the Diagnosis of Renal Light-Chain Amyloidosis[J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES,2013,345(1):18-21.
APA Zhou, Fu-de.,Zhang, Lu-xia.,Yao, Ying.,Wang, Su-xia.,Zou, Wan-zhong.,...&Zhao, Ming-hui.(2013).Immunofixation Electrophoresis Was Highly Specific for the Diagnosis of Renal Light-Chain Amyloidosis.AMERICAN JOURNAL OF THE MEDICAL SCIENCES,345(1),18-21.
MLA Zhou, Fu-de,et al."Immunofixation Electrophoresis Was Highly Specific for the Diagnosis of Renal Light-Chain Amyloidosis".AMERICAN JOURNAL OF THE MEDICAL SCIENCES 345.1(2013):18-21.
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