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学科主题: 药学
题名:
Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains
作者: Xu, Jianfeng; Yang, Zhenjun; Dammermann, Werner; Zhang, Liangren; Guse, Andreas H.; Zhang, Li-he
刊名: JOURNAL OF MEDICINAL CHEMISTRY
发表日期: 2006-09-07
DOI: 10.1021/jm060320e
卷: 49, 期:18, 页:5501-5512
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ADENOSINE-DIPHOSPHORIBOSE CADPR ; CALCIUM-RELEASE ACTIVITY ; INDUCED CA2+ RELEASE ; CA2+-MOBILIZING 2ND-MESSENGER ; CARBOCYCLIC-RIBOSE ; T-LYMPHOCYTES ; DERIVATIVES ; SIGNALS ; MIMICS ; POTENT
英文摘要:

Novel analogues of cADPR with adenine as base and ether (10a) or different alkane chain (10b-d) substitutions of the northern ribose were synthesized from protected imidazole nucleoside 1 in good yields. The pharmacological activities of cyclic inosine diphosphoribose ether (cIDPRE) and the compounds (10a-d) were analyzed in intact human Jurkat T-lymphocytes. The results indicate that the analogues 10a-d permeate the plasma membrane and are weak agonists of the cADPR/ ryanodine receptor signaling system in intact human Jurkat T cells. They are the first membrane-permeant and biologically active cADPR analogues that contain ether or alkane bridges instead of the northern ribose and retain adenine as its base.

语种: 英语
WOS记录号: WOS:000240149000013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67340
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Univ Hamburg, Med Ctr hamburg Eppendorf, Ctr Med Expt, Inst Biochem & Mol Biol Cellular Signal Transduct, D-20246 Hamburg, Germany

Recommended Citation:
Xu, Jianfeng,Yang, Zhenjun,Dammermann, Werner,et al. Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains[J]. JOURNAL OF MEDICINAL CHEMISTRY,2006,49(18):5501-5512.
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