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Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains
Xu, Jianfeng; Yang, Zhenjun; Dammermann, Werner; Zhang, Liangren; Guse, Andreas H.; Zhang, Li-he
刊名JOURNAL OF MEDICINAL CHEMISTRY
2006-09-07
DOI10.1021/jm060320e
49期:18页:5501-5512
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]ADENOSINE-DIPHOSPHORIBOSE CADPR ; CALCIUM-RELEASE ACTIVITY ; INDUCED CA2+ RELEASE ; CA2+-MOBILIZING 2ND-MESSENGER ; CARBOCYCLIC-RIBOSE ; T-LYMPHOCYTES ; DERIVATIVES ; SIGNALS ; MIMICS ; POTENT
英文摘要

Novel analogues of cADPR with adenine as base and ether (10a) or different alkane chain (10b-d) substitutions of the northern ribose were synthesized from protected imidazole nucleoside 1 in good yields. The pharmacological activities of cyclic inosine diphosphoribose ether (cIDPRE) and the compounds (10a-d) were analyzed in intact human Jurkat T-lymphocytes. The results indicate that the analogues 10a-d permeate the plasma membrane and are weak agonists of the cADPR/ ryanodine receptor signaling system in intact human Jurkat T cells. They are the first membrane-permeant and biologically active cADPR analogues that contain ether or alkane bridges instead of the northern ribose and retain adenine as its base.

语种英语
WOS记录号WOS:000240149000013
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67340
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Univ Hamburg, Med Ctr hamburg Eppendorf, Ctr Med Expt, Inst Biochem & Mol Biol Cellular Signal Transduct, D-20246 Hamburg, Germany
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GB/T 7714
Xu, Jianfeng,Yang, Zhenjun,Dammermann, Werner,et al. Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains[J]. JOURNAL OF MEDICINAL CHEMISTRY,2006,49(18):5501-5512.
APA Xu, Jianfeng,Yang, Zhenjun,Dammermann, Werner,Zhang, Liangren,Guse, Andreas H.,&Zhang, Li-he.(2006).Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains.JOURNAL OF MEDICINAL CHEMISTRY,49(18),5501-5512.
MLA Xu, Jianfeng,et al."Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains".JOURNAL OF MEDICINAL CHEMISTRY 49.18(2006):5501-5512.
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