北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 眼科  > 期刊论文
学科主题: 临床医学
题名:
The effect of intravitreal bevacizumab injection as the initial treatment for Coats′ disease
作者: Zheng, Xiao-Xue1,2; Jiang, Yan-Rong1,2,3
关键词: Coats&prime ; disease ; Bevacizumab ; Children ; Adults ; Vitreoretinal fibrosis
刊名: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
发表日期: 2014
DOI: 10.1007/s00417-013-2409-1
卷: 252, 期:1, 页:35-42
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: PROLIFERATIVE DIABETIC-RETINOPATHY ; ENDOTHELIAL GROWTH-FACTOR ; MACULAR DEGENERATION ; RETINAL-DETACHMENT ; RESOLUTION ; FIBROSIS ; LECTURE ; VEGF
英文摘要:

In Coats′ disease, the most recent development in the treatment has been the intravitreal injection of anti-VEGF agents. The purpose of this article was to evaluate the effect of intravitreal bevacizumab as the initial treatment for Coats′ disease in children and adults.

The study included 14 pediatric patients and five adult patients with Coats′ disease. They were treated with intravitreal bevacizumab (1.25 mg/0.05 ml) as the initial treatment, combined with or without other treatments. The analyses included the evaluation of basic clinical conditions.

In the pediatric group, after a mean of 9.1 months of follow-up, the differences in visual acuity were significant for the comparisons between the baseline examination and the follow-up examinations carried out at weeks 6, 12, and 24 after the baseline (P = 0.006, P = 0.004, P = 0.005 respectively). Vitreoretinal fibrosis was observed in three patients (n = 3, 21.4 %), among whom two showed fibrosis before treatment. All of the pediatric patients showed a resolution of fluid and exudation, and regression of the telangiectasia. In the adult group, after a mean of 10.6 months of follow-up, the differences in visual acuity were not statistically significant (P > 0.05) between the baseline and follow-up examinations. Vitreoretinal fibrosis (n = 2, 40 %) was observed in two patients who both showed fibrosis before treatment. All of the adult patients showed a resolution of fluid and exudation, and regression of the telangiectasia. The differences in the change of BCVA between children and adults were not significant (P > 0.05) during the follow-up examinations.

The intravitreal injection of bevacizumab as the initial treatment is associated with a measurable gain in visual acuity in patients with Coats′ disease. Resolution of the subretinal fluid and exudation, and regression of the telangiectasia were observed in both pediatric and adult patients. Vitreoretinal fibrosis may be one of the natural courses of Coats′ disease, and it remains uncertain whether bevacizumab accelerates the fibrosis phenomenon.

语种: 英语
所属项目编号: RDC2012-21 ; 81271027
项目资助者: Study and Development Fund of People&prime ; s Hospital of Peking University ; National Natural Science Foundation of China
WOS记录号: WOS:000329243500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67348
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peoples Hosp, Dept Ophthalmol, Beijing, Peoples R China
2.Peking Univ, Minist Educ, Key Lab Vis Loss & Restorat, Beijing 100044, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China

Recommended Citation:
Zheng, Xiao-Xue,Jiang, Yan-Rong. The effect of intravitreal bevacizumab injection as the initial treatment for Coats′ disease[J]. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,2014,252(1):35-42.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zheng, Xiao-Xue]'s Articles
[Jiang, Yan-Rong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zheng, Xiao-Xue]‘s Articles
[Jiang, Yan-Rong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace