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学科主题临床医学
The effect of intravitreal bevacizumab injection as the initial treatment for Coats′ disease
Zheng, Xiao-Xue1,2; Jiang, Yan-Rong1,2,3
关键词Coats&prime disease Bevacizumab Children Adults Vitreoretinal fibrosis
刊名GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
2014
DOI10.1007/s00417-013-2409-1
252期:1页:35-42
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]PROLIFERATIVE DIABETIC-RETINOPATHY ; ENDOTHELIAL GROWTH-FACTOR ; MACULAR DEGENERATION ; RETINAL-DETACHMENT ; RESOLUTION ; FIBROSIS ; LECTURE ; VEGF
英文摘要

In Coats′ disease, the most recent development in the treatment has been the intravitreal injection of anti-VEGF agents. The purpose of this article was to evaluate the effect of intravitreal bevacizumab as the initial treatment for Coats′ disease in children and adults.

The study included 14 pediatric patients and five adult patients with Coats′ disease. They were treated with intravitreal bevacizumab (1.25 mg/0.05 ml) as the initial treatment, combined with or without other treatments. The analyses included the evaluation of basic clinical conditions.

In the pediatric group, after a mean of 9.1 months of follow-up, the differences in visual acuity were significant for the comparisons between the baseline examination and the follow-up examinations carried out at weeks 6, 12, and 24 after the baseline (P = 0.006, P = 0.004, P = 0.005 respectively). Vitreoretinal fibrosis was observed in three patients (n = 3, 21.4 %), among whom two showed fibrosis before treatment. All of the pediatric patients showed a resolution of fluid and exudation, and regression of the telangiectasia. In the adult group, after a mean of 10.6 months of follow-up, the differences in visual acuity were not statistically significant (P > 0.05) between the baseline and follow-up examinations. Vitreoretinal fibrosis (n = 2, 40 %) was observed in two patients who both showed fibrosis before treatment. All of the adult patients showed a resolution of fluid and exudation, and regression of the telangiectasia. The differences in the change of BCVA between children and adults were not significant (P > 0.05) during the follow-up examinations.

The intravitreal injection of bevacizumab as the initial treatment is associated with a measurable gain in visual acuity in patients with Coats′ disease. Resolution of the subretinal fluid and exudation, and regression of the telangiectasia were observed in both pediatric and adult patients. Vitreoretinal fibrosis may be one of the natural courses of Coats′ disease, and it remains uncertain whether bevacizumab accelerates the fibrosis phenomenon.

语种英语
WOS记录号WOS:000329243500007
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67348
专题北京大学第二临床医学院_眼科
作者单位1.Peoples Hosp, Dept Ophthalmol, Beijing, Peoples R China
2.Peking Univ, Minist Educ, Key Lab Vis Loss & Restorat, Beijing 100044, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Xiao-Xue,Jiang, Yan-Rong. The effect of intravitreal bevacizumab injection as the initial treatment for Coats′ disease[J]. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,2014,252(1):35-42.
APA Zheng, Xiao-Xue,&Jiang, Yan-Rong.(2014).The effect of intravitreal bevacizumab injection as the initial treatment for Coats′ disease.GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,252(1),35-42.
MLA Zheng, Xiao-Xue,et al."The effect of intravitreal bevacizumab injection as the initial treatment for Coats′ disease".GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 252.1(2014):35-42.
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