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学科主题: 临床医学
题名:
Evaluation of pathological diagnosis using ultrasonography-guided lymph node core-needle biopsy
作者: Yuan Jing2; Li Xiang-hong1
关键词: ultrasonography ; needle biopsy ; lymph node ; diagnosis
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2010-03-20
DOI: 10.3760/cma.j.issn.0366-6999.2010.06.010
卷: 123, 期:6, 页:690-694
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: LYMPHADENOPATHY ; CYTOLOGY ; MASSES ; NECK
英文摘要:

Background Image-guided core-needle biopsy as a minimally invasive procedure has partially replaced excisional biopsy of the lymph node. However, it is still a great challenge to pathologists. The aim of this study was to survey and evaluate the accuracy of pathological diagnosis using the ultrasonography (US)-guided core-needle biopsy (CNB) of the lymph node.

Methods Lymph node CNBs of 1119 consecutive patients from the Chinese People′s Liberation Army (PLA) General Hospital were reviewed retrospectively. Biopsies were performed following outpatient procedures with direct US guiding by using 18-gauge cutting needle. The tissues of CNB were prepared according to the routine paraffin embedding and hematoxylin-eosin staining. Ancillary studies, including acid-fast staining and immunohistochemical staining, were performed when necessary.

Results The age range was 1 year old to 85 years old. Locations of the lymph node were as follows: cervical area (n=482), clavicular region (n=227), retroperitoneum (n=150), axilla (n=93), groin (n=79), abdomen/mesentery (n=44), submaxillary region (n=33), postauricular region (n=4), iliac fosa (n=3), parotid (n=2), hepatic hilar region (n=1), and elbow (n=1). The histological diagnoses were conclusive in 815 cases (73%) and inconclusive in 304 cases (27%). The conclusive cases mainly included metastatic carcinoma (n=449), tuberculosis (n=111), lymphoma/leukemia (n=124), reactive hyperplasia (n=87), and other rare diseases (n=44). The reasons for inconclusive cases were insufficient material for diagnosis, noncompliance of outpatients, or crushing artifacts of tissues caused by operation.

Conclusions US-guided CNB can obtain lymphoid tissues from nearly all parts of the body for diagnostic purposes. Conclusive pathological diagnosis can be made in most of cases when adequate material was provided. Besides metastatic carcinoma, lymphomas with special immunophenotype can be accurately diagnosed and subclassified by US-guided CNB. Chin Med J 2010;123(6):690-694

语种: 英语
WOS记录号: WOS:000276230600010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67362
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.Peking Univ, Dept Pathol, Beijing Canc Hosp & Inst,Sch Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R China

Recommended Citation:
Yuan Jing,Li Xiang-hong. Evaluation of pathological diagnosis using ultrasonography-guided lymph node core-needle biopsy[J]. CHINESE MEDICAL JOURNAL,2010,123(6):690-694.
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