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学科主题: 基础医学
题名:
Swine and rabbits are the main reservoirs of hepatitis E virus in China: detection of HEV RNA in feces of farmed and wild animals
作者: Xia, Junke1,2; Zeng, Hang1,2; Liu, Lin1,2; Zhang, Yulin1,2; Liu, Peng1,2; Geng, Jiabao3; Wang, Lin1,2; Wang, Ling1,2; Zhuang, Hui1,2
刊名: ARCHIVES OF VIROLOGY
发表日期: 2015-11-01
DOI: 10.1007/s00705-015-2574-0
卷: 160, 期:11, 页:2791-2798
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: CROSS-SPECIES INFECTION ; UNITED-STATES ; ZOONOTIC TRANSMISSION ; PHYLOGENETIC ANALYSIS ; DOMESTIC-ANIMALS ; FAMILY HEPEVIRIDAE ; EASTERN CHINA ; LIVER SAUSAGE ; FULL-GENOME ; FOOD-BORNE
英文摘要:

Hepatitis E virus (HEV) infection is recognized as a zoonosis. The prevalence of HEV RNA and anti-HEV antibodies in many animal species has been reported, but the host range of HEV is unclear. The aims of this study were to investigate HEV infection in various animal species and to determine the reservoirs of HEV. Eight hundred twenty-two fecal samples from 17 mammal species and 67 fecal samples from 24 avian species were collected in China and tested for HEV RNA by RT-nPCR. The products of PCR were sequenced and analyzed phylogenetically. The positive rates of HEV RNA isolated from pigs in Beijing, Shandong, and Henan were 33 %, 30 %, and 92 %, respectively, and that from rabbits in Beijing was 5 %. HEV RNA was not detectable in farmed foxes, sheep or sika deer, or in wild animals in zoos, including wild boars, yaks, camels, Asiatic black bears, African lions, red pandas, civets, wolves, jackals and primates. Sequence analysis revealed that swine isolates had 97.8 %-98.4 % nucleotide sequence identity to genotype 4d isolates from patients in Shandong and Jiangsu of China. Phylogenetic analysis showed that swine HEV isolates belong to genotype 4, including subgenotype 4h in Henan and 4d in Beijing and Shandong. The rabbit HEV strains shared 93 %-99 % nucleotide sequence identity with rabbit strains isolated from Inner Mongolia. In conclusion, swine and rabbits have been confirmed to be the main reservoirs of HEV in China.

语种: 英语
所属项目编号: 81271827 ; 20120001110098
项目资助者: National Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education
WOS记录号: WOS:000366805400014
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67366
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.81st Hosp PLA, Inst Hepatol, Nanjing, Jiangsu, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Microbiol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Ctr Infect Dis, Beijing 100191, Peoples R China

Recommended Citation:
Xia, Junke,Zeng, Hang,Liu, Lin,et al. Swine and rabbits are the main reservoirs of hepatitis E virus in China: detection of HEV RNA in feces of farmed and wild animals[J]. ARCHIVES OF VIROLOGY,2015,160(11):2791-2798.
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