IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Swine and rabbits are the main reservoirs of hepatitis E virus in China: detection of HEV RNA in feces of farmed and wild animals
Xia, Junke1,2; Zeng, Hang1,2; Liu, Lin1,2; Zhang, Yulin1,2; Liu, Peng1,2; Geng, Jiabao3; Wang, Lin1,2; Wang, Ling1,2; Zhuang, Hui1,2
刊名ARCHIVES OF VIROLOGY
2015-11-01
DOI10.1007/s00705-015-2574-0
160期:11页:2791-2798
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
研究领域[WOS]Virology
关键词[WOS]CROSS-SPECIES INFECTION ; UNITED-STATES ; ZOONOTIC TRANSMISSION ; PHYLOGENETIC ANALYSIS ; DOMESTIC-ANIMALS ; FAMILY HEPEVIRIDAE ; EASTERN CHINA ; LIVER SAUSAGE ; FULL-GENOME ; FOOD-BORNE
英文摘要

Hepatitis E virus (HEV) infection is recognized as a zoonosis. The prevalence of HEV RNA and anti-HEV antibodies in many animal species has been reported, but the host range of HEV is unclear. The aims of this study were to investigate HEV infection in various animal species and to determine the reservoirs of HEV. Eight hundred twenty-two fecal samples from 17 mammal species and 67 fecal samples from 24 avian species were collected in China and tested for HEV RNA by RT-nPCR. The products of PCR were sequenced and analyzed phylogenetically. The positive rates of HEV RNA isolated from pigs in Beijing, Shandong, and Henan were 33 %, 30 %, and 92 %, respectively, and that from rabbits in Beijing was 5 %. HEV RNA was not detectable in farmed foxes, sheep or sika deer, or in wild animals in zoos, including wild boars, yaks, camels, Asiatic black bears, African lions, red pandas, civets, wolves, jackals and primates. Sequence analysis revealed that swine isolates had 97.8 %-98.4 % nucleotide sequence identity to genotype 4d isolates from patients in Shandong and Jiangsu of China. Phylogenetic analysis showed that swine HEV isolates belong to genotype 4, including subgenotype 4h in Henan and 4d in Beijing and Shandong. The rabbit HEV strains shared 93 %-99 % nucleotide sequence identity with rabbit strains isolated from Inner Mongolia. In conclusion, swine and rabbits have been confirmed to be the main reservoirs of HEV in China.

语种英语
WOS记录号WOS:000366805400014
项目编号81271827 ; 20120001110098
资助机构National Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67366
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
医学人文研究院/公共教学部_哲学与社会科学系
作者单位1.81st Hosp PLA, Inst Hepatol, Nanjing, Jiangsu, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Microbiol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Ctr Infect Dis, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Xia, Junke,Zeng, Hang,Liu, Lin,et al. Swine and rabbits are the main reservoirs of hepatitis E virus in China: detection of HEV RNA in feces of farmed and wild animals[J]. ARCHIVES OF VIROLOGY,2015,160(11):2791-2798.
APA Xia, Junke.,Zeng, Hang.,Liu, Lin.,Zhang, Yulin.,Liu, Peng.,...&Zhuang, Hui.(2015).Swine and rabbits are the main reservoirs of hepatitis E virus in China: detection of HEV RNA in feces of farmed and wild animals.ARCHIVES OF VIROLOGY,160(11),2791-2798.
MLA Xia, Junke,et al."Swine and rabbits are the main reservoirs of hepatitis E virus in China: detection of HEV RNA in feces of farmed and wild animals".ARCHIVES OF VIROLOGY 160.11(2015):2791-2798.
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