学科主题临床医学
Differentiation of rat bone marrow stem cells in liver after partial hepatectomy
Zhan, Yu-Tao; Wang, Yu; Wei, Lai; Liu, Bin; Chen, Hong-Song; Cong, Xu; Fei, Ran
关键词bone marrow stem cells liver regeneration differentiation
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2006-08-21
12期:31页:5051-5054
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]IN-VIVO ; HEPATOCYTES ; LYMPHOCYTES ; MICE
英文摘要

AIM: To investigate the differentiation of rat bone marrow stem cells in liver after partial hepatectomy.

METHODS: Bone marrow cells were collected from the tibia of rat with partial hepatectomy, the medial and left hepatic lobes were excised. The bone marrow stem cells (Thy(+)CD3(-)CD45RA(-) cells) were enriched from the bone marrow cells by depleting red cells and fluorescence-activated cell sorting. The sorted bone marrow stem cells were labeled by PKH26-GL in vitro and autotransplanted by portal vein injection. After 2 wk, the transplanted bone marrow stem cells in liver were examined by the immunohistochemistry of albumin (hepatocyte-specific marker).

RESULTS: The bone marrow stem cells (Thy(+)CD3(-)CD45RA(-): cells) accounted for 2.8% of bone marrow cells without red cells. The labeling rate of 10 mu M PKH26-GL on sorted bone marrow stem cells was about 95%. There were sporadic PKH26-GL-labeled cells among hepatocytes in liver tissue section, and some of the cells expressed albumin.

CONCLUSION: Rat bone marrow stem cells can differentiate into hepatocytes in regenerative environment and may participate in liver regeneration after partial hepatectomy. (C) 2006 The WJG Press. All rights reserved.

语种英语
WOS记录号WOS:000240185800019
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67368
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Capital Med Univ, Beijing Tongren Hosp, Dept Gastroenterol, Beijing 100730, Peoples R China
2.Beijing Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China
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GB/T 7714
Zhan, Yu-Tao,Wang, Yu,Wei, Lai,et al. Differentiation of rat bone marrow stem cells in liver after partial hepatectomy[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2006,12(31):5051-5054.
APA Zhan, Yu-Tao.,Wang, Yu.,Wei, Lai.,Liu, Bin.,Chen, Hong-Song.,...&Fei, Ran.(2006).Differentiation of rat bone marrow stem cells in liver after partial hepatectomy.WORLD JOURNAL OF GASTROENTEROLOGY,12(31),5051-5054.
MLA Zhan, Yu-Tao,et al."Differentiation of rat bone marrow stem cells in liver after partial hepatectomy".WORLD JOURNAL OF GASTROENTEROLOGY 12.31(2006):5051-5054.
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