北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 儿科  > 期刊论文
学科主题: 临床医学
题名:
Population pharmacokinetics of valproate in Chinese children with epilepsy
作者: De-chun Jiang; Li Wang; Yu-qin Wang; Lin Li; Wei Lu; Xiang-rong Bai
关键词: population pharmacokinetics ; valproic acid ; epilepsy ; children ; Bayesian method ; NONMEM software ; individualized dosage regimens
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2007-10-01
DOI: 10.1111/j.1745-7254.2007.00704.x
卷: 28, 期:10, 页:1677-1684
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: ANTIEPILEPTIC DRUGS ; SODIUM VALPROATE ; ACID ; MODEL ; CLEARANCE ; DESIGN ; NONMEM
英文摘要:

Aim: The aim of the present study is to establish a population pharmacokinetic (PPK) model of valproate (VPA) in Chinese epileptic children to promote the reasonable use of anti-epileptic drugs. Methods: Sparse data of VPA serum concentrations from 417 epileptic children were collected. These patients were divided into 2 groups: the PPK model group (n=317) and the PPK valid group (n=100). The PPK parameter values of VPA were calculated by NONMEM software using the data of the PPK model group. A basic model and a final model were set up. To validate the 2 models, the concentrations of PPK valid group were predicted by each model, respectively. The mean prediction error (MPE), mean squared prediction error (MSPE), root mean squared prediction error (RMSPE), weight residues (WRES), and the 95% confidence intervals (95% CI) were also calculated. Then, the values between the 2 models were compared. Results: The PPK of VPA was determined by a 1-compartment model with a first-order absorption process. The basic model was: Ka=3.09 (h(-1)), V/F=20.4 (L), CL/F=0.296 (L/h). The final model was: Ka=0.251+2.24.(1-HS) (h(-1)), V/F=2.88+0.157.WT (L), CL/F=0.106(0.98.CO)+ 0.0157.AGE (L/h). For the basic model, the MPE, MSPE, RMSPE, WRES, and the 95% CI were -23.53 (-30.36, -16.70), 3728.96 (2872.72, 4585.20), 39.62 (34.34, 44.90), and -0.06 (-0.14, 0.02), respectively. For the final model, the MPE, MSPE, RMSPE, WRES, and the 95% CI were -1.16 (-4.85, 2.53), 1002.83 (1050.64, 1143.61), 23.04 (21.12, 24.96), and 0.08 (-0.04, 0.20), respectively. The final model was more optimal than the basic model. Conclusion: The PPK model of VPA in Chinese epileptic children was successfully established. It will be valuable to facilitate individualized dosage regimens.

语种: 英语
WOS记录号: WOS:000249699600023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67371
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Capital Med Univ, Xuan Wu Hosp, Dept Pharm, Beijing 100053, Peoples R China
2.Peking Univ, First Hosp, Dept Pediat, Beijing 100034, Peoples R China
3.Capital Med Univ, Xuan Wu Hosp, Dept Pharmacol, Educ Minist Key Lab Neurogegenerat Dis, Beijing 100053, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
De-chun Jiang,Li Wang,Yu-qin Wang,et al. Population pharmacokinetics of valproate in Chinese children with epilepsy[J]. ACTA PHARMACOLOGICA SINICA,2007,28(10):1677-1684.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[De-chun Jiang]'s Articles
[Li Wang]'s Articles
[Yu-qin Wang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[De-chun Jiang]‘s Articles
[Li Wang]‘s Articles
[Yu-qin Wang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace