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学科主题: 临床医学
题名:
Transcription factors engaged in development of NK cells are commonly expressed in nasal NK/T-cell lymphomas
作者: Zhang, Shuang1; Li, Ting1; Zhang, Bo2; Nong, Lin1; Aozasa, Katsuyuki3
关键词: Extranodal NK/T-cell lymphoma, nasal type ; T-bet ; EOMES ; ETS-1 ; MEF
刊名: HUMAN PATHOLOGY
发表日期: 2011-09-01
DOI: 10.1016/j.humpath.2009.11.022
卷: 42, 期:9, 页:1319-1328
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: T-BOX GENES ; NATURAL-KILLER ; EOMESODERMIN EXPRESSION ; BET ; EFFECTOR ; DIFFERENTIATION ; REARRANGEMENT ; DISORDERS ; LEUKEMIAS ; LINEAGE
英文摘要:

Extranodal natural killer/T (NK/T)-cell lymphoma, nasal type, is a prevailing tumor in Asia with distinct clinical, pathologic, and immunophenotypic features. Previous study revealed amplification and overexpression of T-bet in extranodal NK/T-cell lymphoma, nasal type. As a transcription factor, T-bet functionally cooperates with its family member eomesodermin (EOMES) or ETS family members (ETS-1 and MEF) and positively regulates the development and cytotoxic function of natural killer (NK) cells. To evaluate their role in extranodal NK/T-cell lymphoma, nasal type, the expression status and clinical relevance of these genes were analyzed in 40 cases of this tumor by in situ hybridization and immunohistochemistry. Tumor cells in all 40 cases expressed cytotoxic granule proteins, of which 39 contained the Epstein-Barr virus (EBV) genome. Two (8.7%) of 23 cases showed T-cell receptor (TCR) gamma gene clonal rearrangement, confirming cytotoxic T lineage of cell derivation. The expression level of T-bet as revealed by in situ hybridization and immunohistochemistry was high in extranodal NK/T-cell lymphoma, nasal type, (82.5% and 100%) and peripheral T-cell lymphomas (94.4% and 72.2%) but not in mature B-cell lymphomas in our control group (0% and 0%). By in situ hybridization, high expression of EOMES (80.0%), ETS-1 (82.5%), and MEF (62.5%) was observed in cases of extranodal NK/T-cell lymphoma, nasal type, but none of the control groups and cases expressed these molecules. Coexpression of T-bet and EOMES, ETS-1, or MEF was found in 30 (75%), 25 (62.5%), and 21 cases (52.5%), respectively. The frequency of coexpression of T-bet and EOMES was significantly higher than that of other genes. Transcription factors engaged in NK-cell development are highly expressed in extranodal NK/T-cell lymphoma, nasal type, suggesting a role in the biologic behavior of this tumor. (C) 2011 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30270517 ; 30770910
项目资助者: Chinese National Natural Sciences Foundation, Beijing, China
WOS记录号: WOS:000294191000014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67375
Appears in Collections:北京大学第一临床医学院_病理科_期刊论文

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作者单位: 1.Osaka Univ, Grad Sch Med, Dept Pathol, Osaka 5650871, Japan
2.Peking Univ, Hosp 1, Dept Pathol, Beijing 100034, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Shuang,Li, Ting,Zhang, Bo,et al. Transcription factors engaged in development of NK cells are commonly expressed in nasal NK/T-cell lymphomas[J]. HUMAN PATHOLOGY,2011,42(9):1319-1328.
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