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Transcription factors engaged in development of NK cells are commonly expressed in nasal NK/T-cell lymphomas
Zhang, Shuang1; Li, Ting1; Zhang, Bo2; Nong, Lin1; Aozasa, Katsuyuki3
关键词Extranodal NK/T-cell lymphoma, nasal type T-bet EOMES ETS-1 MEF
刊名HUMAN PATHOLOGY
2011-09-01
DOI10.1016/j.humpath.2009.11.022
42期:9页:1319-1328
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]T-BOX GENES ; NATURAL-KILLER ; EOMESODERMIN EXPRESSION ; BET ; EFFECTOR ; DIFFERENTIATION ; REARRANGEMENT ; DISORDERS ; LEUKEMIAS ; LINEAGE
英文摘要

Extranodal natural killer/T (NK/T)-cell lymphoma, nasal type, is a prevailing tumor in Asia with distinct clinical, pathologic, and immunophenotypic features. Previous study revealed amplification and overexpression of T-bet in extranodal NK/T-cell lymphoma, nasal type. As a transcription factor, T-bet functionally cooperates with its family member eomesodermin (EOMES) or ETS family members (ETS-1 and MEF) and positively regulates the development and cytotoxic function of natural killer (NK) cells. To evaluate their role in extranodal NK/T-cell lymphoma, nasal type, the expression status and clinical relevance of these genes were analyzed in 40 cases of this tumor by in situ hybridization and immunohistochemistry. Tumor cells in all 40 cases expressed cytotoxic granule proteins, of which 39 contained the Epstein-Barr virus (EBV) genome. Two (8.7%) of 23 cases showed T-cell receptor (TCR) gamma gene clonal rearrangement, confirming cytotoxic T lineage of cell derivation. The expression level of T-bet as revealed by in situ hybridization and immunohistochemistry was high in extranodal NK/T-cell lymphoma, nasal type, (82.5% and 100%) and peripheral T-cell lymphomas (94.4% and 72.2%) but not in mature B-cell lymphomas in our control group (0% and 0%). By in situ hybridization, high expression of EOMES (80.0%), ETS-1 (82.5%), and MEF (62.5%) was observed in cases of extranodal NK/T-cell lymphoma, nasal type, but none of the control groups and cases expressed these molecules. Coexpression of T-bet and EOMES, ETS-1, or MEF was found in 30 (75%), 25 (62.5%), and 21 cases (52.5%), respectively. The frequency of coexpression of T-bet and EOMES was significantly higher than that of other genes. Transcription factors engaged in NK-cell development are highly expressed in extranodal NK/T-cell lymphoma, nasal type, suggesting a role in the biologic behavior of this tumor. (C) 2011 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000294191000014
项目编号30270517 ; 30770910
资助机构Chinese National Natural Sciences Foundation, Beijing, China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67375
专题北京大学第一临床医学院_病理科
作者单位1.Osaka Univ, Grad Sch Med, Dept Pathol, Osaka 5650871, Japan
2.Peking Univ, Hosp 1, Dept Pathol, Beijing 100034, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
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GB/T 7714
Zhang, Shuang,Li, Ting,Zhang, Bo,et al. Transcription factors engaged in development of NK cells are commonly expressed in nasal NK/T-cell lymphomas[J]. HUMAN PATHOLOGY,2011,42(9):1319-1328.
APA Zhang, Shuang,Li, Ting,Zhang, Bo,Nong, Lin,&Aozasa, Katsuyuki.(2011).Transcription factors engaged in development of NK cells are commonly expressed in nasal NK/T-cell lymphomas.HUMAN PATHOLOGY,42(9),1319-1328.
MLA Zhang, Shuang,et al."Transcription factors engaged in development of NK cells are commonly expressed in nasal NK/T-cell lymphomas".HUMAN PATHOLOGY 42.9(2011):1319-1328.
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