|Demographic and Clinical Features and Prescribing Patterns of Psychotropic Medications in Patients with the Melancholic Subtype of Major Depressive Disorder in China|
|Xiang, Yu-Tao1,2; Wang, Gang2; Hu, Chen2; Guo, Tong2; Ungvari, Gabor S.3; Kilbourne, Amy M.4,5; Lai, Kelly Y. C.1; Si, Tian-Mei6,7; Zheng, Qi-Wen8; Chen, Da-Fang8; Fang, Yi-Ru9; Lu, Zheng10; Yang, Hai-Chen11; Hu, Jian12; Chen, Zhi-Yu13; Huang, Yi14; Sun, Jing15; Wang, Xiao-Ping16; Li, Hui-Chun17; Zhang, Jin-Bei18; Chiu, Helen F. K.1|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||NIGELLA-SATIVA SEEDS ; 1ST 3 YEARS ; OPIOID RECEPTOR ; FOOD ALLERGY ; MAST-CELLS ; DOUBLE-BLIND ; PHARMACOLOGICAL CHARACTERIZATION ; MOUSE MODEL ; THYMOQUINONE ; MU|
Background: Little has been known about the demographic and clinical features of the melancholic subtype of major depressive disorder (MDD) in Chinese patients. This study examined the frequency of melancholia in Chinese MDD patients and explored its demographic and clinical correlates and prescribing patterns of psychotropic drugs.
Methods: A consecutively collected sample of 1,178 patients with MDD were examined in 13 psychiatric hospitals or psychiatric units of general hospitals in China nationwide. The cross-sectional data of patients′ demographic and clinical characteristics and prescriptions of psychotropic drugs were recorded using a standardized protocol and data collection procedure. The diagnosis of the melancholic subtype was established using the Mini International Neuropsychiatric Interview (MINI). Medications ascertained included antidepressants, mood stabilizers, antipsychotics and benzodiazepines.
Results: Six hundred and twenty nine (53.4%) of the 1,178 patients fulfilled criteria for melancholia. In multiple logistic regression analyses, compared to non-melancholic counterparts, melancholic MDD patients were more likely to be male and receive benzodiazepines, had more frequent suicide ideations and attempts and seasonal depressive episodes, while they were less likely to be employed and receive antidepressants and had less family history of psychiatric disorders and lifetime depressive episodes.
Conclusions: The demographic and clinical features of melancholic MDD in Chinese patients were not entirely consistent with those found in Western populations. Compared to non-melancholic MDD patients, melancholic patients presented with different demographic and clinical features, which have implications for treatment decisions.
|资助机构||Ministry of Science and Technology of China ; AstraZeneca China|
|作者单位||1.Hangzhou Seventh Peoples Hosp, Hangzhou, Zhejiang, Peoples R China|
2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
3.Vet Adm Ann Arbor Ctr Clin Management Res, Ann Arbor, MI USA
4.Minist Mental Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
5.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
6.Capital Med Univ, Beijing Anding Hosp, Mood Disorders Ctr, Beijing, Peoples R China
7.Univ Notre Dame Australia, Marian Ctr, Perth, WA, Australia
8.Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI 48109 USA
9.Peking Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
10.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Div Mood Disorders, Shanghai 200030, Peoples R China
11.Tongji Univ, Shanghai Tongji Hosp, Sch Med, Shanghai 200092, Peoples R China
12.Shenzhen Mental Hlth Ctr, Div Mood Disorders, Shenzhen, Guangdong, Peoples R China
13.Harbin Med Univ, First Hosp, Harbin, Heilongjiang Pr, Peoples R China
14.Sichuan Univ, W China Hosp, Chengdu 610064, Sichuan Provinc, Peoples R China
15.Nanjing Med Univ, Affiliated Brain Hosp, Nanjing, Jiangsu, Peoples R China
16.Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China
17.Zhejiang Univ, Affiliated Hosp 2, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China
18.Sun Yat Sen Univ, Affiliated Hosp 3, Guangzhou 510275, Guangdong, Peoples R China
|Xiang, Yu-Tao,Wang, Gang,Hu, Chen,et al. Demographic and Clinical Features and Prescribing Patterns of Psychotropic Medications in Patients with the Melancholic Subtype of Major Depressive Disorder in China[J]. PLOS ONE,2012,7(6).|
|APA||Xiang, Yu-Tao.,Wang, Gang.,Hu, Chen.,Guo, Tong.,Ungvari, Gabor S..,...&Chiu, Helen F. K..(2012).Demographic and Clinical Features and Prescribing Patterns of Psychotropic Medications in Patients with the Melancholic Subtype of Major Depressive Disorder in China.PLOS ONE,7(6).|
|MLA||Xiang, Yu-Tao,et al."Demographic and Clinical Features and Prescribing Patterns of Psychotropic Medications in Patients with the Melancholic Subtype of Major Depressive Disorder in China".PLOS ONE 7.6(2012).|