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Membrane transport of vanadium compounds and the interaction with the erythrocyte membrane
Yang, XG; Wang, K; Lu, JF; Crans, DC
关键词vanadium complexes transport biopotency diabetes
刊名COORDINATION CHEMISTRY REVIEWS
2003-02-01
237期:1-2页:103-111
收录类别SCI ; ISTP
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Chemistry, Inorganic & Nuclear
研究领域[WOS]Chemistry
关键词[WOS]MYELIN BASIC-PROTEIN ; SECONDARY STRUCTURE ; INFRARED-SPECTRA ; INSULIN ; CHEMISTRY ; VANADATE ; COMPLEXES ; BINDING ; METABOLISM ; WATER
英文摘要

In the present work, the membrane transport and the biotransformation of vanadate, bis(maltolato)oxovanadium (VO(ma)(2)), and vanadyl acetylacetonate (VO(acac)(2)) were investigated to explore the relationship with their insulin-like activity. Cellular uptake kinetics were performed by ICP-AES and EPR. The uptake of VO(acac)(2) and VO(ma)(2) by human erythrocytes showed intracellular vanadium level higher than NaVO3 and the membrane transport of these two vanadyl complexes was presumed to be via the passive diffusion mechanism. A fraction of vanadyl was oxidized to anionic vanadium(V) species and also entered the cells by the anion channel. The stability of VO(acac)(2) and VO(ma)(2) to oxidation in human erythrocyte membrane vesicles was investigated using EPR. VO(ma)(2) was found to be more sensitive to oxidation than VO(acac)(2) in aqueous buffer solution. However, in the presence of membrane vesicles, the oxidation of VO(ma)(2) and VO(acac)(2) was retarded and the differences between them became insignificant. Thus, the lifetime of vanadium complexes might be prolonged in physiological fluids. The interaction with membranes appears to be important in the stabilization of vanadyl complexes. Meanwhile, structural changes of membrane proteins were also observed. The higher uptake of the vanadyl complexes and the observed changes of membrane proteins might attribute to their insulin-mimetic mechanisms and toxicities. (C) 2002 Elsevier Science B.V. All rights reserved.

语种英语
WOS记录号WOS:000181701500011
引用统计
被引频次:61[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67377
专题北京大学药学院_化学生物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
2.Peking Univ, Natl Res Labs Nat & Biomimet Drugs, Beijing 100083, Peoples R China
3.Colorado State Univ, Coll Nat Sci, Dept Chem, Ft Collins, CO 80523 USA
4.Colorado State Univ, Coll Nat Sci, Cell & Mol Biol Program, Ft Collins, CO 80523 USA
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GB/T 7714
Yang, XG,Wang, K,Lu, JF,et al. Membrane transport of vanadium compounds and the interaction with the erythrocyte membrane[J]. COORDINATION CHEMISTRY REVIEWS,2003,237(1-2):103-111.
APA Yang, XG,Wang, K,Lu, JF,&Crans, DC.(2003).Membrane transport of vanadium compounds and the interaction with the erythrocyte membrane.COORDINATION CHEMISTRY REVIEWS,237(1-2),103-111.
MLA Yang, XG,et al."Membrane transport of vanadium compounds and the interaction with the erythrocyte membrane".COORDINATION CHEMISTRY REVIEWS 237.1-2(2003):103-111.
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