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学科主题: 临床医学
题名:
Sulfur Dioxide: a Novel Gaseous Signal in the Regulation of Cardiovascular Functions
作者: Liu, D.1; Jin, H.1; Tang, C.2,3; Du, J.1,3
关键词: Cardiovascular ; gaseous signal ; sulfur dioxide ; pathophysiology ; physiology ; toxicology
刊名: MINI-REVIEWS IN MEDICINAL CHEMISTRY
发表日期: 2010-10-01
卷: 10, 期:11, 页:1039-1045
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: TUMOR-SUPPRESSOR GENES ; SPONTANEOUSLY HYPERTENSIVE-RAT ; BRONCHIAL EPITHELIAL-CELLS ; CONTAINING AMINO-ACIDS ; HEART-RATE-VARIABILITY ; HYDROGEN-SULFIDE ; OXIDATIVE DAMAGE ; AIR-POLLUTION ; PULMONARY-HYPERTENSION ; ACTIVATED NEUTROPHILS
英文摘要:

The atmospheric pollutant sulfur dioxide (SO(2)) is endogenously generated from the normal metabolism of sulfur-containing amino acids through the aspartate aminotransferase pathway. SO(2) is produced in cardiovascular tissues, and the aspartate aminotransferase mRNA is localized in endothelia and in vascular smooth muscle cells near the endothelial layer. Recent studies explored the physiological and pathophysiological effects of endogenous SO(2) on the cardiovascular system, and various potential mechanisms were found. These discoveries suggest a novel role of endogenous SO(2) in the modulation of the cardiovascular system and provide a basis for new treatments for cardiovascular diseases.

语种: 英语
所属项目编号: 30630031 ; 30821001 ; 30801251 ; 307001 ; 2006CB503807
项目资助者: National Natural Science Foundation of China ; Ministry of Education, China ; Major Basic Research Program of China
WOS记录号: WOS:000285417600004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67378
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiol, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China

Recommended Citation:
Liu, D.,Jin, H.,Tang, C.,et al. Sulfur Dioxide: a Novel Gaseous Signal in the Regulation of Cardiovascular Functions[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY,2010,10(11):1039-1045.
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