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Sulfur Dioxide: a Novel Gaseous Signal in the Regulation of Cardiovascular Functions
Liu, D.1; Jin, H.1; Tang, C.2,3; Du, J.1,3
关键词Cardiovascular gaseous signal sulfur dioxide pathophysiology physiology toxicology
刊名MINI-REVIEWS IN MEDICINAL CHEMISTRY
2010-10-01
10期:11页:1039-1045
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]TUMOR-SUPPRESSOR GENES ; SPONTANEOUSLY HYPERTENSIVE-RAT ; BRONCHIAL EPITHELIAL-CELLS ; CONTAINING AMINO-ACIDS ; HEART-RATE-VARIABILITY ; HYDROGEN-SULFIDE ; OXIDATIVE DAMAGE ; AIR-POLLUTION ; PULMONARY-HYPERTENSION ; ACTIVATED NEUTROPHILS
英文摘要

The atmospheric pollutant sulfur dioxide (SO(2)) is endogenously generated from the normal metabolism of sulfur-containing amino acids through the aspartate aminotransferase pathway. SO(2) is produced in cardiovascular tissues, and the aspartate aminotransferase mRNA is localized in endothelia and in vascular smooth muscle cells near the endothelial layer. Recent studies explored the physiological and pathophysiological effects of endogenous SO(2) on the cardiovascular system, and various potential mechanisms were found. These discoveries suggest a novel role of endogenous SO(2) in the modulation of the cardiovascular system and provide a basis for new treatments for cardiovascular diseases.

语种英语
WOS记录号WOS:000285417600004
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67378
专题北京大学第一临床医学院_儿科
北京大学基础医学院
作者单位1.Minist Educ, Key Lab Mol Cardiol, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
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GB/T 7714
Liu, D.,Jin, H.,Tang, C.,et al. Sulfur Dioxide: a Novel Gaseous Signal in the Regulation of Cardiovascular Functions[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY,2010,10(11):1039-1045.
APA Liu, D.,Jin, H.,Tang, C.,&Du, J..(2010).Sulfur Dioxide: a Novel Gaseous Signal in the Regulation of Cardiovascular Functions.MINI-REVIEWS IN MEDICINAL CHEMISTRY,10(11),1039-1045.
MLA Liu, D.,et al."Sulfur Dioxide: a Novel Gaseous Signal in the Regulation of Cardiovascular Functions".MINI-REVIEWS IN MEDICINAL CHEMISTRY 10.11(2010):1039-1045.
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