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学科主题: 临床医学
题名:
Global analysis of differentially expressed genes in androgen-independent prostate cancer
作者: Wei, Q.; Li, M.; Fu, X.; Tang, R.; Na, Y.; Jiang, M.; Li, Y.
关键词: androgen independent ; expression profile ; hormone ; angiogenesis ; microarray
刊名: PROSTATE CANCER AND PROSTATIC DISEASES
发表日期: 2007-05-01
DOI: 10.1038/sj.pcan.4500933
卷: 10, 期:2, 页:167-174
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Urology & Nephrology
研究领域[WOS]: Oncology ; Urology & Nephrology
关键词[WOS]: GROWTH-FACTOR VEGF ; TISSUE INHIBITOR ; CARCINOMA-CELLS ; GASTRIC-CARCINOMA ; BREAST-CANCER ; HORMONE ; TUMOR ; ACTIVATION ; APOPTOSIS ; PROTEIN
英文摘要:

Progression to androgen independent ( AI) is the main cause of death in prostate cancer, and the mechanism is still unclear. By reviewing the expression profiles of 26 prostate cancer samples in a holistic view, we found a group of genes differentially expressed in AI compared with androgen-dependent groups ( P- value < 0.01, t- test). Focusing on apoptosis, proliferation, hormone and angiogenesis, we found a group of genes such as thioredoxin domain containing 5, tumor necrosis factor receptor superfamily, member 10a, ribosomal protein S19 and Janus kinase 2 upregulated in AI prostate cancer, could play important roles in the transition from AD to AI and could be biomarkers of prognosis.

语种: 英语
WOS记录号: WOS:000247026300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67379
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Fudan Univ, Sch Life Sci, Inst Genet, State Key Lab Genet Engn, Shanghai 200433, Peoples R China
2.Peking Univ, First Hosp, Dept Urol, Beijing 100871, Peoples R China

Recommended Citation:
Wei, Q.,Li, M.,Fu, X.,et al. Global analysis of differentially expressed genes in androgen-independent prostate cancer[J]. PROSTATE CANCER AND PROSTATIC DISEASES,2007,10(2):167-174.
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