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学科主题临床医学
Global analysis of differentially expressed genes in androgen-independent prostate cancer
Wei, Q.; Li, M.; Fu, X.; Tang, R.; Na, Y.; Jiang, M.; Li, Y.
关键词androgen independent expression profile hormone angiogenesis microarray
刊名PROSTATE CANCER AND PROSTATIC DISEASES
2007-05-01
DOI10.1038/sj.pcan.4500933
10期:2页:167-174
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Urology & Nephrology
研究领域[WOS]Oncology ; Urology & Nephrology
关键词[WOS]GROWTH-FACTOR VEGF ; TISSUE INHIBITOR ; CARCINOMA-CELLS ; GASTRIC-CARCINOMA ; BREAST-CANCER ; HORMONE ; TUMOR ; ACTIVATION ; APOPTOSIS ; PROTEIN
英文摘要

Progression to androgen independent ( AI) is the main cause of death in prostate cancer, and the mechanism is still unclear. By reviewing the expression profiles of 26 prostate cancer samples in a holistic view, we found a group of genes differentially expressed in AI compared with androgen-dependent groups ( P- value < 0.01, t- test). Focusing on apoptosis, proliferation, hormone and angiogenesis, we found a group of genes such as thioredoxin domain containing 5, tumor necrosis factor receptor superfamily, member 10a, ribosomal protein S19 and Janus kinase 2 upregulated in AI prostate cancer, could play important roles in the transition from AD to AI and could be biomarkers of prognosis.

语种英语
WOS记录号WOS:000247026300010
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被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67379
专题北京大学第一临床医学院_泌尿外科
作者单位1.Fudan Univ, Sch Life Sci, Inst Genet, State Key Lab Genet Engn, Shanghai 200433, Peoples R China
2.Peking Univ, First Hosp, Dept Urol, Beijing 100871, Peoples R China
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Wei, Q.,Li, M.,Fu, X.,et al. Global analysis of differentially expressed genes in androgen-independent prostate cancer[J]. PROSTATE CANCER AND PROSTATIC DISEASES,2007,10(2):167-174.
APA Wei, Q..,Li, M..,Fu, X..,Tang, R..,Na, Y..,...&Li, Y..(2007).Global analysis of differentially expressed genes in androgen-independent prostate cancer.PROSTATE CANCER AND PROSTATIC DISEASES,10(2),167-174.
MLA Wei, Q.,et al."Global analysis of differentially expressed genes in androgen-independent prostate cancer".PROSTATE CANCER AND PROSTATIC DISEASES 10.2(2007):167-174.
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