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学科主题临床医学
A multi-centre randomised trial comparing ultrasound vs mammography for screening breast cancer in high-risk Chinese women
Shen, S.1; Zhou, Y.1; Xu, Y.1; Zhang, B.2; Duan, X.3; Huang, R.4; Li, B.5; Shi, Y.6; Shao, Z.7; Liao, H.8; Jiang, J.9; Shen, N.10; Zhang, J.11; Yu, C.12; Jiang, H.13; Li, S.14; Han, S.15; Ma, J.16,17; Sun, Q.1
关键词breast cancer screening mammography ultrasound cost
刊名BRITISH JOURNAL OF CANCER
2015-03-17
DOI10.1038/bjc.2015.33
112期:6页:998-1004
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]DENSE BREASTS ; ULTRASONOGRAPHY ; PREDICTION ; VALIDATION ; MODELS ; AREAS ; AGE
英文摘要

Background: Chinese women tend to have small and dense breasts and ultrasound is a common method for breast cancer screening in China. However, its efficacy and cost comparing with mammography has not been evaluated in randomised trials.

Methods: At 14 breast centres across China during 2008-2010, 13 339 high-risk women aged 30-65 years were randomised to be screened by mammography alone, ultrasound alone, or by both methods at enrolment and 1-year follow-up.

Results: A total of 12 519 and 8692 women underwent the initial and second screenings, respectively. Among the 30 cancers (of which 15 were stage 0/I) detected, 5 (0.72/1000) were in the mammography group, 11 (1.51/1000) in the ultrasound group, and 14 (2.02/1000) in the combined group (P = 0.12). In the combined group, ultrasound detected all the 14 cancers, whereas mammography detected 8, making ultrasound more sensitive (100 vs 57.1%, P=0.04) with a better diagnostic accuracy (0.999 vs 0.766, P=0.01). There was no difference between mammography and ultrasound in specificity (100 vs 99.9%, P=0.51) and positive predictive value (72.7 vs 70.0%; P=0.87). To detect one cancer, the costs of ultrasound, mammography, and combined modality were $7876, $45 253, and $21 599, respectively.

Conclusions: Ultrasound is superior to mammography for breast cancer screening in high-risk Chinese women.

语种英语
WOS记录号WOS:000351388200007
项目编号2006BAI02A09 ; D090507043409009
资助机构Eleventh Five-year Key Programs for Science and Technology Development of China ; Beijing Municipal Science and Technology Key Development Program
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67380
专题北京大学第一临床医学院
作者单位1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Breast Surg, Beijing 100730, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll, Canc Inst & Hosp, Dept Breast Surg, Beijing 100021, Peoples R China
3.Peking Univ, Affiliated Hosp 1, Dept Breast Surg, Beijing 100034, Peoples R China
4.Matern & Child Care Ctr Qinhuangdao, Dept Breast Surg, Qinhuangdao 066000, Hebei, Peoples R China
5.Beijing Hosp, Dept Breast Surg, Minist Hlth, Beijing 100005, Peoples R China
6.ShanXi Tradit Med Hosp, Dept Breast Surg, Taiyuan 030012, Shanxi, Peoples R China
7.Fudan Univ, Canc Hosp, Dept Breast Surg, Shanghai 200032, Peoples R China
8.Yingbin Hosp Yancheng, Dept Breast Surg, Yancheng 224005, Jiangsu, Peoples R China
9.Third Mil Med Univ, Southwest Hosp, Dept Breast Surg, Chongqing 400038, Peoples R China
10.Populat & Family Planning Serv Ctr Zhuhai, Dept Women Hlth, Zhuhai 519000, Guangdong, Peoples R China
11.Tianjin Med Univ, Canc Hosp, Dept Breast Surg, Tianjin 300060, Peoples R China
12.Peoples Liberat Army, Chinese Hosp 307, Dept Breast Surg, Beijing 100071, Peoples R China
13.Capital Med Univ, Beijing Chaoyang Hosp, Dept Breast Surg, Beijing 100043, Peoples R China
14.Beijing Mil Area Command, Gen Hosp, Dept Breast Surg, Beijing 100700, Peoples R China
15.Chinese Acad Med Sci, Peking Union Med Coll, Inst Basic Med Sci, Dept Epidemiol & Med Stat, Beijing 100730, Peoples R China
16.Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Div Network Med, Boston, MA 02115 USA
17.Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
推荐引用方式
GB/T 7714
Shen, S.,Zhou, Y.,Xu, Y.,et al. A multi-centre randomised trial comparing ultrasound vs mammography for screening breast cancer in high-risk Chinese women[J]. BRITISH JOURNAL OF CANCER,2015,112(6):998-1004.
APA Shen, S..,Zhou, Y..,Xu, Y..,Zhang, B..,Duan, X..,...&Sun, Q..(2015).A multi-centre randomised trial comparing ultrasound vs mammography for screening breast cancer in high-risk Chinese women.BRITISH JOURNAL OF CANCER,112(6),998-1004.
MLA Shen, S.,et al."A multi-centre randomised trial comparing ultrasound vs mammography for screening breast cancer in high-risk Chinese women".BRITISH JOURNAL OF CANCER 112.6(2015):998-1004.
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