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Protective Effect of Renshen Yangrong Decoction ((sic)) on Bone Marrow against Radiation Injury in Mouse
Chen Yan-zhi1; Lin Fei2; Zhuang Gui-bao1; Ren Yan1; Li Ping-ping1
关键词Renshen Yangrong Decoction mouse anti-radiation peripheral white blood cell count bone marrow nucleated cell count bone marrow micronucleus count
刊名CHINESE JOURNAL OF INTEGRATIVE MEDICINE
2011-06-01
DOI10.1007/s11655-011-0634-1
17期:6页:453-458
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
资助者Scientific and Technologic Items of Traditional Chinese Medicine Administration of Beijing City ; Scientific and Technologic Items of Traditional Chinese Medicine Administration of Beijing City
研究领域[WOS]Integrative & Complementary Medicine
英文摘要

Objective: To explore the effect of Renshen Yangrong Decoction ((sic), RYD) in protecting bone marrow from radiation injury. Methods: One hundred and eighty Kuming mice were subjected to the three tests for anti-radiation injury effect evaluation, i.e. the test of peripheral white blood cell (WBC) count, the test of bone marrow nucleated cell count, and the bone marrow micronucleus test, using 60 mice for each test. The mice in each test were divided into 6 groups: the blank control group, the model control group, the positive control group treated by Shiyiwei Shenqi Tablet ((sic)1.0 g/kg), and three RYD groups treated with high (42.0 g/kg), moderate (21.0 g/kg), and low (10.5 g/kg) doses of crude drugs of RYD, with 10 mice in each group. The treatment was given by gastrogavage perfusion continuously for 7-14 days before mice received (60)Co- gamma ray radiation and continued until the end of the experiment. The body weights of the mice were monitored, the changes in peripheral WBC and bone marrow nucleated cells were counted, and the variation in bone marrow micronucleated cells was observed on the respective appointed days. Results: A significant decrease in body weight, peripheral WBC count, and bone marrow nucleated cell count, as well as marked changes in bone marrow micronucleated cells were observed in the mice after radiation, indicating that the radiation injury model was successfully established. As compared with the model control group, the decrease in body weight, peripheral WBC count, and bone marrow nucleated cell count, as well as the increase in bone marrow micronucleus cell count in the high dosage RYD treated group were obviously inhibited or lessened (P<0.05 or P<0.01). Conclusion: RYD showed obvious protective effect in mice with bone marrow injury induced by radiation.

语种英语
所属项目编号2004 JingZhongZhong IV 15
资助者Scientific and Technologic Items of Traditional Chinese Medicine Administration of Beijing City ; Scientific and Technologic Items of Traditional Chinese Medicine Administration of Beijing City
WOS记录号WOS:000291406000009
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67389
Collection北京大学临床肿瘤学院
作者单位1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Dept Integrat Tradit Chi, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Natl Inst Control Pharmaceut & Biol Prod, Beijing 100050, Peoples R China
Recommended Citation
GB/T 7714
Chen Yan-zhi,Lin Fei,Zhuang Gui-bao,et al. Protective Effect of Renshen Yangrong Decoction ((sic)) on Bone Marrow against Radiation Injury in Mouse[J]. CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2011,17(6):453-458.
APA Chen Yan-zhi,Lin Fei,Zhuang Gui-bao,Ren Yan,&Li Ping-ping.(2011).Protective Effect of Renshen Yangrong Decoction ((sic)) on Bone Marrow against Radiation Injury in Mouse.CHINESE JOURNAL OF INTEGRATIVE MEDICINE,17(6),453-458.
MLA Chen Yan-zhi,et al."Protective Effect of Renshen Yangrong Decoction ((sic)) on Bone Marrow against Radiation Injury in Mouse".CHINESE JOURNAL OF INTEGRATIVE MEDICINE 17.6(2011):453-458.
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