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学科主题: 临床医学
题名:
Diet-Dependent Net Acid Load and Risk of Incident Hypertension in United States Women
作者: Zhang, Luxia1,3; Curhan, Gary C.; Forman, John P.
关键词: acid-base equilibrium ; hypertension ; risk factors ; epidemiology ; human
刊名: HYPERTENSION
发表日期: 2009-10-01
DOI: 10.1161/HYPERTENSIONAHA.109.135582
卷: 54, 期:4, 页:751-755
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: FOOD FREQUENCY QUESTIONNAIRE ; SERUM ANION GAP ; BLOOD-PRESSURE ; BONE-RESORPTION ; POTASSIUM ; EXCRETION ; HUMANS ; ASSOCIATION ; PROTEIN ; HEALTH
英文摘要:

Animal and human studies suggest a potential link between acid-base status and blood pressure. Contemporary Western diets yield a daily systemic acid load of varying amounts, yet the association with hypertension has never been explored. We prospectively examined the association between the diet-dependent net acid load (also known as the estimated net endogenous acid production) and the risk of incident hypertension among 87 293 women without a history of hypertension in the Nurses′ Health Study II. We also used the ratio of animal protein intake to potassium intake as an alternative evaluation of diet-dependent net acid load. We identified 15 385 incident cases of hypertension during 995 239 person-years of follow-up. After adjusting for potential confounders, women in the top decile of estimated diet-dependent net acid load had an increased risk of hypertension (relative risk: 1.14; 95% CI: 1.05 to 1.24; P for trend = 0.01) compared with women in the bottom decile. To test whether the association between estimated diet-dependent net acid load and hypertension is independent of its individual components, an additional adjustment for intakes of protein and potassium was made and resulted in a relative risk of 1.23 (95% CI: 1.08 to 1.41; P for trend = 0.003) for the top decile of estimated diet-dependent net acid load. Results of the ratio of animal protein intake to potassium intake were similar with those of estimated diet-depend net acid load. In conclusion, a high diet-dependent net acid load is independently associated with a higher risk of incident hypertension. (Hypertension. 2009; 54: 751-755.)

语种: 英语
所属项目编号: 0535401T ; HL079929-01 ; CA50385
项目资助者: American Heart Association ; National Institutes of Health ; Beijing Municipal Science and Technology Commission
WOS记录号: WOS:000269852600016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67391
Appears in Collections:北京大学第一临床医学院_大内科_期刊论文

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作者单位: 1.Brigham & Womens Hosp, Channing Lab, Div Renal, Dept Med, Boston, MA 02115 USA
2.Harvard Univ, Sch Med, Boston, MA USA
3.Peking Univ, Hosp 1, Dept Med, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Luxia,Curhan, Gary C.,Forman, John P.. Diet-Dependent Net Acid Load and Risk of Incident Hypertension in United States Women[J]. HYPERTENSION,2009,54(4):751-755.
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