| 学科主题 | 药学 |
| A novel flavonoid from Lespedeza virgata (Thunb.) DC.: Structural elucidation and antioxidative activity | |
| Tan, Li; Zhang, Xiu-Feng; Yan, Bao-Zhen; Shi, Hai-Ming; Du, Li-Bo; Zhang, Ya-Zhou; Wang, Lan-Fen; Tang, Ya-Lin; Liu, Yang | |
| 关键词 | Lespedeza virgata flavonoid NMR antioxidative activity |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 2007-11-15 | |
| DOI | 10.1016/j.bmcl.2007.09.003 |
| 卷 | 17期:22页:6311-6315 |
| 收录类别 | SCI |
| 文章类型 | Article |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Chemistry, Medicinal ; Chemistry, Organic |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Chemistry |
| 关键词[WOS] | ELECTRON-TRANSFER MECHANISMS ; RADICAL-SCAVENGING REACTION ; STEP HYDROGEN-TRANSFER ; EUCHRESTA-FORMOSANA ; ROOTS ; (+)-CATECHIN ; FLAVANONE ; HOMOLOBA |
| 英文摘要 | Bioactivity guided fractionation of the ethanolic extract of the whole plants of Lespedeza virgata (Thunb.) DC. resulted in the isolation of a novel flavonoid (1) along with five known compounds 2-6. The molecular and structural formula as well as the stereochemistry of compound 1 were determined using data obtained from (1)H and (13)C NMR spectra, DEPT135 and by 2D HSQC, HMBC, (1)H-(1)H correlated spectroscopy ((1)H-(1)H COSY), and nuclear overhauser effect spectroscopy (NOESY) experiments. The superoxide anion scavenging activities of all isolated compounds were evaluated by the hypoxanthine nitro blue tetrazolium and ESR methods and the new compound 1 showed the strongest antioxidative activity 95.79% (IC(50) = 0.14 mg/ml). (C) 2007 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000250906200054 |
| Citation statistics | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/67402 |
| Collection | 北京大学药学院_天然药物学系 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab SCUSS, Beijing 100080, Peoples R China 2.Beijing Univ Chem Technol, Fac Sci, Beijing 100029, Peoples R China 3.Peking Univ, Ctr Hlth Sci, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China |
| Recommended Citation GB/T 7714 | Tan, Li,Zhang, Xiu-Feng,Yan, Bao-Zhen,et al. A novel flavonoid from Lespedeza virgata (Thunb.) DC.: Structural elucidation and antioxidative activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(22):6311-6315. |
| APA | Tan, Li.,Zhang, Xiu-Feng.,Yan, Bao-Zhen.,Shi, Hai-Ming.,Du, Li-Bo.,...&Liu, Yang.(2007).A novel flavonoid from Lespedeza virgata (Thunb.) DC.: Structural elucidation and antioxidative activity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,17(22),6311-6315. |
| MLA | Tan, Li,et al."A novel flavonoid from Lespedeza virgata (Thunb.) DC.: Structural elucidation and antioxidative activity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17.22(2007):6311-6315. |
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