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学科主题药学
A novel flavonoid from Lespedeza virgata (Thunb.) DC.: Structural elucidation and antioxidative activity
Tan, Li; Zhang, Xiu-Feng; Yan, Bao-Zhen; Shi, Hai-Ming; Du, Li-Bo; Zhang, Ya-Zhou; Wang, Lan-Fen; Tang, Ya-Lin; Liu, Yang
关键词Lespedeza virgata flavonoid NMR antioxidative activity
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2007-11-15
DOI10.1016/j.bmcl.2007.09.003
17期:22页:6311-6315
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]ELECTRON-TRANSFER MECHANISMS ; RADICAL-SCAVENGING REACTION ; STEP HYDROGEN-TRANSFER ; EUCHRESTA-FORMOSANA ; ROOTS ; (+)-CATECHIN ; FLAVANONE ; HOMOLOBA
英文摘要

Bioactivity guided fractionation of the ethanolic extract of the whole plants of Lespedeza virgata (Thunb.) DC. resulted in the isolation of a novel flavonoid (1) along with five known compounds 2-6. The molecular and structural formula as well as the stereochemistry of compound 1 were determined using data obtained from (1)H and (13)C NMR spectra, DEPT135 and by 2D HSQC, HMBC, (1)H-(1)H correlated spectroscopy ((1)H-(1)H COSY), and nuclear overhauser effect spectroscopy (NOESY) experiments. The superoxide anion scavenging activities of all isolated compounds were evaluated by the hypoxanthine nitro blue tetrazolium and ESR methods and the new compound 1 showed the strongest antioxidative activity 95.79% (IC(50) = 0.14 mg/ml). (C) 2007 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000250906200054
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67402
Collection北京大学药学院_天然药物学系
作者单位1.Chinese Acad Sci, Inst Chem, State Key Lab SCUSS, Beijing 100080, Peoples R China
2.Beijing Univ Chem Technol, Fac Sci, Beijing 100029, Peoples R China
3.Peking Univ, Ctr Hlth Sci, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Tan, Li,Zhang, Xiu-Feng,Yan, Bao-Zhen,et al. A novel flavonoid from Lespedeza virgata (Thunb.) DC.: Structural elucidation and antioxidative activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(22):6311-6315.
APA Tan, Li.,Zhang, Xiu-Feng.,Yan, Bao-Zhen.,Shi, Hai-Ming.,Du, Li-Bo.,...&Liu, Yang.(2007).A novel flavonoid from Lespedeza virgata (Thunb.) DC.: Structural elucidation and antioxidative activity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,17(22),6311-6315.
MLA Tan, Li,et al."A novel flavonoid from Lespedeza virgata (Thunb.) DC.: Structural elucidation and antioxidative activity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17.22(2007):6311-6315.
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