A novel flavonoid from Lespedeza virgata (Thunb.) DC.: Structural elucidation and antioxidative activity

doi:10.1016/j.bmcl.2007.09.003

IR@PKUHSC > 北京大学药学院 > 天然药物学系

学科主题	药学
	A novel flavonoid from Lespedeza virgata (Thunb.) DC.: Structural elucidation and antioxidative activity
	Tan, Li ; Zhang, Xiu-Feng ; Yan, Bao-Zhen ; Shi, Hai-Ming ; Du, Li-Bo ; Zhang, Ya-Zhou ; Wang, Lan-Fen ; Tang, Ya-Lin ; Liu, Yang
关键词	Lespedeza virgata flavonoid NMR antioxidative activity
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2007-11-15
DOI	10.1016/j.bmcl.2007.09.003
卷	17 期:22 页:6311-6315
收录类别	SCI
文章类型	Article
WOS标题词	Science & Technology
类目[WOS]	Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]	Pharmacology & Pharmacy ; Chemistry
关键词[WOS]	ELECTRON-TRANSFER MECHANISMS ; RADICAL-SCAVENGING REACTION ; STEP HYDROGEN-TRANSFER ; EUCHRESTA-FORMOSANA ; ROOTS ; (+)-CATECHIN ; FLAVANONE ; HOMOLOBA
英文摘要	Bioactivity guided fractionation of the ethanolic extract of the whole plants of Lespedeza virgata (Thunb.) DC. resulted in the isolation of a novel flavonoid (1) along with five known compounds 2-6. The molecular and structural formula as well as the stereochemistry of compound 1 were determined using data obtained from (1)H and (13)C NMR spectra, DEPT135 and by 2D HSQC, HMBC, (1)H-(1)H correlated spectroscopy ((1)H-(1)H COSY), and nuclear overhauser effect spectroscopy (NOESY) experiments. The superoxide anion scavenging activities of all isolated compounds were evaluated by the hypoxanthine nitro blue tetrazolium and ESR methods and the new compound 1 showed the strongest antioxidative activity 95.79% (IC(50) = 0.14 mg/ml). (C) 2007 Elsevier Ltd. All rights reserved.
语种	英语
WOS记录号	WOS:000250906200054
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.bjmu.edu.cn/handle/400002259/67402
专题	北京大学药学院_天然药物学系
作者单位	1.Chinese Acad Sci, Inst Chem, State Key Lab SCUSS, Beijing 100080, Peoples R China 2.Beijing Univ Chem Technol, Fac Sci, Beijing 100029, Peoples R China 3.Peking Univ, Ctr Hlth Sci, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China
推荐引用方式 GB/T 7714	Tan, Li,Zhang, Xiu-Feng,Yan, Bao-Zhen,et al. A novel flavonoid from Lespedeza virgata (Thunb.) DC.: Structural elucidation and antioxidative activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(22):6311-6315.
APA	Tan, Li.,Zhang, Xiu-Feng.,Yan, Bao-Zhen.,Shi, Hai-Ming.,Du, Li-Bo.,...&Liu, Yang.(2007).A novel flavonoid from Lespedeza virgata (Thunb.) DC.: Structural elucidation and antioxidative activity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,17(22),6311-6315.
MLA	Tan, Li,et al."A novel flavonoid from Lespedeza virgata (Thunb.) DC.: Structural elucidation and antioxidative activity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17.22(2007):6311-6315.