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PHOTODYNAMIC THERAPY FOR ACUTE CENTRAL SEROUS CHORIORETINOPATHY The Safe Effective Lowest Dose of Verteporfin
Zhao, Ming-Wei; Zhou, Peng; Xiao, Hong-Xiang; Lv, Yong-Shun; Li, Chun-An; Liu, Guo-Dong; Li, Xiao-Xin
关键词acute central serous chorioretinopathy dose of verteporfin photodynamic therapy
刊名RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
2009-09-01
29期:8页:1155-1161
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]CHOROIDAL NEOVASCULARIZATION ; RETINOPATHY ; TRIAL
英文摘要

Purpose: To find the lowest effective dose of verteporfin in the treatment of acute central serous chorioretinopathy with photodynamic therapy (PDT).

Methods: Patients with acute central serous chorioretinopathy were chosen and treated with PDT with verteporfin. Decreasing doses of verteporfin were applied to the first 7 patients at 70%, 60%, 50%, 40%, 30%, 20%, and 10% of the full dose (6 mg/m(2)). Other patients were treated with the effective lowest dose (30% of full dose). Fluorescein angiography, indocyanine green angiography, and optical coherence tomography recordings were performed before PDT and at 1 week, 2 weeks, 1 month, 3 months, 6 months, 9 months, and 12 months after PDT. The pretreatment and posttreatment best-corrected visual acuity were compared.

Results: Fifteen eyes of 15 patients with the diagnosis of acute central serous chorioretinopathy were chosen and treated with PDT. The results at each dose suggested that 30% of the full dose of verteporfin was the lowest effective dose. The mean improvement in visual acuity was 4.1 +/- 0.25 lines at follow-up (mean 11.8 months). No complications were found during observation, except 1 patient at 70% dose who developed retinal angiomatous proliferation at the 1-month follow-up.

Conclusion: On the basis of the results of this study and available information regarding the expected rate of spontaneous resolution, 30% verteporfin dose seems to be safe and effective in the treatment of acute central serous chorioretinopathy. RETINA 29:1155-1161, 2009

语种英语
WOS记录号WOS:000270051800015
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67409
专题北京大学第二临床医学院_眼科
作者单位Peking Univ, Dept Ophthalmol, Peoples Hosp, Beijing 100044, Peoples R China
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GB/T 7714
Zhao, Ming-Wei,Zhou, Peng,Xiao, Hong-Xiang,et al. PHOTODYNAMIC THERAPY FOR ACUTE CENTRAL SEROUS CHORIORETINOPATHY The Safe Effective Lowest Dose of Verteporfin[J]. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES,2009,29(8):1155-1161.
APA Zhao, Ming-Wei.,Zhou, Peng.,Xiao, Hong-Xiang.,Lv, Yong-Shun.,Li, Chun-An.,...&Li, Xiao-Xin.(2009).PHOTODYNAMIC THERAPY FOR ACUTE CENTRAL SEROUS CHORIORETINOPATHY The Safe Effective Lowest Dose of Verteporfin.RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES,29(8),1155-1161.
MLA Zhao, Ming-Wei,et al."PHOTODYNAMIC THERAPY FOR ACUTE CENTRAL SEROUS CHORIORETINOPATHY The Safe Effective Lowest Dose of Verteporfin".RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 29.8(2009):1155-1161.
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