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学科主题: 临床医学
题名:
Risk factors for interstitial cystitis/painful bladder syndrome in patients with lower urinary tract symptoms: a Chinese multi-center study
作者: Li Gui-zhong1; Zhang Ning1; Du Peng1; Yang Yong1; Wu Shi-liang2; Xiao Yun-xiang2; Jin Rui3; Liu Lei3; Shen Hong4; Dai Yi4
关键词: painful bladder syndrome ; interstitial cystitis ; questionnaire ; risk factor
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2010-10-20
DOI: 10.3760/cma.j.issn.0366-6999.2010.20.018
卷: 123, 期:20, 页:2842-2846
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: MANAGED CARE POPULATION ; PELVIC PAIN SYNDROME ; POTASSIUM SENSITIVITY ; WOMEN ; PREVALENCE ; MEN ; DIAGNOSES ; OVERLAP ; LIFE
英文摘要:

Background Despite 100 years of research, the continued absence of well-established risk factors impedes the diagnosis and treatment of interstitial cystitis/painful bladder syndrome (IC/PBS). We aimed to identify risk factors in patients with lower urinary tract symptoms (LUTS) without urinary tract infection or benign prostate hyperplasia in China.

Methods A total of 397 outpatients with LUTS presenting for care to urology clinics in several hospitals throughout China were surveyed using a standardized questionnaire and validated outcome measures. The definitions for painful bladder syndrome based on the O′Leary-Sant interstitial cystitis symptom and problem indices were used. The prevalence of possible risk factors was analyzed using the Fisher′s exact test and Pearson chi-square test, and multivariate predictive models were developed using binary Logistic regression methods.

Results Of those multi-centre patients surveyed, including 174 women and 223 men, 41% (162/397) met criteria for painful bladder syndrome. There was a significant difference between women and men (55% (95/174) vs. 30% (67/223), P < 0.001). Women with IC/PBS were more likely than those without IC/PBS to report a history of gynecological infections (odds ratio (OR): 2.85; 95% confidence interval (CI): 1.32-6.16, P=0.007), intake of stimulatory foods (OR: 3.52; 95% CI: 1.50-8.30; P=0.004), irritable bowel (OR: 3.46; 95% CI: 1.22-9.80; P=0.014) and/or anorectal disease (OR: 2.68; 95% CI: 1.12-6.40, P=0.023). After adjusting for confounding factors, bladder pain was significantly associated with stimulatory foods (OR: 3.85; 95% CI: 1.58-9.36, P=0.003) and anorectal disease (OR: 2.76; 95% CI: 1.09-7.04, P=0.03) in women. Caffeine beverage intake (OR: 3.54; 95% CI: 1.54-8.12, P=0.003) was identified the only modifiable association noted in multivariate analysis of men.

Conclusions We found that stimulatory foods, anorectal disease and caffeine beverages are potential risk factors for IC/PBS. Further studies are necessary to determine their role in the pathogenesis of this disorder. Chin Med J 2010;123(20):2842-2846

语种: 英语
所属项目编号: 2007-2-369
项目资助者: Development of Medical Research Foundation of the Capital
WOS记录号: WOS:000283694200018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67410
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Chaoyang Hosp, Dept Urol, Beijing 100020, Peoples R China
2.Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
3.Cent S Univ, Xiangya Hosp 2, Dept Urol, Changsha 410011, Hunan, Peoples R China
4.Sichuan Univ, W China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China

Recommended Citation:
Li Gui-zhong,Zhang Ning,Du Peng,et al. Risk factors for interstitial cystitis/painful bladder syndrome in patients with lower urinary tract symptoms: a Chinese multi-center study[J]. CHINESE MEDICAL JOURNAL,2010,123(20):2842-2846.
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