|Risk factors for interstitial cystitis/painful bladder syndrome in patients with lower urinary tract symptoms: a Chinese multi-center study|
|Li Gui-zhong1; Zhang Ning1; Du Peng1; Yang Yong1; Wu Shi-liang2; Xiao Yun-xiang2; Jin Rui3; Liu Lei3; Shen Hong4; Dai Yi4|
|关键词||painful bladder syndrome interstitial cystitis questionnaire risk factor|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||MANAGED CARE POPULATION ; PELVIC PAIN SYNDROME ; POTASSIUM SENSITIVITY ; WOMEN ; PREVALENCE ; MEN ; DIAGNOSES ; OVERLAP ; LIFE|
Background Despite 100 years of research, the continued absence of well-established risk factors impedes the diagnosis and treatment of interstitial cystitis/painful bladder syndrome (IC/PBS). We aimed to identify risk factors in patients with lower urinary tract symptoms (LUTS) without urinary tract infection or benign prostate hyperplasia in China.
Methods A total of 397 outpatients with LUTS presenting for care to urology clinics in several hospitals throughout China were surveyed using a standardized questionnaire and validated outcome measures. The definitions for painful bladder syndrome based on the O′Leary-Sant interstitial cystitis symptom and problem indices were used. The prevalence of possible risk factors was analyzed using the Fisher′s exact test and Pearson chi-square test, and multivariate predictive models were developed using binary Logistic regression methods.
Results Of those multi-centre patients surveyed, including 174 women and 223 men, 41% (162/397) met criteria for painful bladder syndrome. There was a significant difference between women and men (55% (95/174) vs. 30% (67/223), P < 0.001). Women with IC/PBS were more likely than those without IC/PBS to report a history of gynecological infections (odds ratio (OR): 2.85; 95% confidence interval (CI): 1.32-6.16, P=0.007), intake of stimulatory foods (OR: 3.52; 95% CI: 1.50-8.30; P=0.004), irritable bowel (OR: 3.46; 95% CI: 1.22-9.80; P=0.014) and/or anorectal disease (OR: 2.68; 95% CI: 1.12-6.40, P=0.023). After adjusting for confounding factors, bladder pain was significantly associated with stimulatory foods (OR: 3.85; 95% CI: 1.58-9.36, P=0.003) and anorectal disease (OR: 2.76; 95% CI: 1.09-7.04, P=0.03) in women. Caffeine beverage intake (OR: 3.54; 95% CI: 1.54-8.12, P=0.003) was identified the only modifiable association noted in multivariate analysis of men.
Conclusions We found that stimulatory foods, anorectal disease and caffeine beverages are potential risk factors for IC/PBS. Further studies are necessary to determine their role in the pathogenesis of this disorder. Chin Med J 2010;123(20):2842-2846
|资助机构||Development of Medical Research Foundation of the Capital|
|作者单位||1.Capital Med Univ, Beijing Chaoyang Hosp, Dept Urol, Beijing 100020, Peoples R China|
2.Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
3.Cent S Univ, Xiangya Hosp 2, Dept Urol, Changsha 410011, Hunan, Peoples R China
4.Sichuan Univ, W China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China
|Li Gui-zhong,Zhang Ning,Du Peng,et al. Risk factors for interstitial cystitis/painful bladder syndrome in patients with lower urinary tract symptoms: a Chinese multi-center study[J]. CHINESE MEDICAL JOURNAL,2010,123(20):2842-2846.|
|APA||Li Gui-zhong.,Zhang Ning.,Du Peng.,Yang Yong.,Wu Shi-liang.,...&Dai Yi.(2010).Risk factors for interstitial cystitis/painful bladder syndrome in patients with lower urinary tract symptoms: a Chinese multi-center study.CHINESE MEDICAL JOURNAL,123(20),2842-2846.|
|MLA||Li Gui-zhong,et al."Risk factors for interstitial cystitis/painful bladder syndrome in patients with lower urinary tract symptoms: a Chinese multi-center study".CHINESE MEDICAL JOURNAL 123.20(2010):2842-2846.|