北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 药剂学系  > 期刊论文
学科主题: 药学
题名:
The antiangiogenic efficacy of NGR-modified PEG-DSPE micelles containing paclitaxel (NGR-M-PTX) for the treatment of glioma in rats
作者: Zhao, Bo-Jun1; Ke, Xi-Yu1; Huang, Yue1; Chen, Xiao-Mei1; Zhao, Xin1; Zhao, Bing-Xiang1; Lu, Wan-liang1,2; Lou, Jin-Ning3; Zhang, Xuan1; Zhang, Qiang1,2
关键词: Aminopeptidase N (APN) ; Asn-Gly-Arg (NGR) ; paclitaxel (PTX) ; DSPE-PEG micelles ; brain glioma-bearing rats ; antitumor efficacy
刊名: JOURNAL OF DRUG TARGETING
发表日期: 2011-06-01
DOI: 10.3109/1061186X.2010.504267
卷: 19, 期:5, 页:382-390
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: CATIONIC LIPOSOMES ; AMINOPEPTIDASE-N ; FIGHTING CANCER ; BRAIN-TUMORS ; MOUSE MODEL ; IN-VITRO ; CHEMOTHERAPY ; BINDING ; CELLS ; ANGIOGENESIS
英文摘要:

Aminopeptidase N (APN), recognized by Asn-Gly-Arg (NGR) peptides, is expressed in the pericytes associated with the BBB, and the main objective of this study is to confirm the hypothesis that NGR-modified DSPE-PEG micelles containing paclitaxel (NGR-M-PTX) can bind to and kill brain tumor angiogenic blood vessels and penetrate into the brain tumor interstitial space, resulting in direct cell death. NGR-M-PTX is prepared by a thin-film hydration method. The in vitro targeting characteristics of NGR-modified micelles on BMEC (murine brain microvascular endothelial cells) were investigated. The effect of NGR-M-PTX on BMEC proliferation and the cytotoxicity of NGR-M-PTX in C6 glioma cells were also tested. The antitumor activity NGR-M-PTX was evaluated in C6 glioma tumor-bearing rats in vivo. The particle size of NGR-M-PTX was approximately 54.2 nm. The drug encapsulation efficiency of NGR-M-PTX was 82.11 +/- 2.82%. The cellular coumarin-6 level of NGR-M-coumarin-6 in the BMEC was about 2.2-fold higher than that of M-coumarin-6. BMEC proliferation was significantly inhibited by NGR-M-PTX. NGR-M-PTX had a much lower IC(50) value than M-PTX and free drug. The growth of C6 glioma tumor was markedly inhibited by NGR-M-PTX compared with Taxol. In conclusion, our results show that antiangiogenic therapy using NGR-M-PTX exhibits potent in vivo antitumor activity in a C6 glioma-bearing animal model.

语种: 英语
所属项目编号: 30873170 ; 2007CB935800 ; 2009CB930300
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China (973 Program)
WOS记录号: WOS:000289995200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67418
Appears in Collections:北京大学药学院_药剂学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.China Japan Friendship Hosp, Minist Hlth, Inst Clin Med Sci, Beijing 100029, Peoples R China

Recommended Citation:
Zhao, Bo-Jun,Ke, Xi-Yu,Huang, Yue,et al. The antiangiogenic efficacy of NGR-modified PEG-DSPE micelles containing paclitaxel (NGR-M-PTX) for the treatment of glioma in rats[J]. JOURNAL OF DRUG TARGETING,2011,19(5):382-390.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhao, Bo-Jun]'s Articles
[Ke, Xi-Yu]'s Articles
[Huang, Yue]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhao, Bo-Jun]‘s Articles
[Ke, Xi-Yu]‘s Articles
[Huang, Yue]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace