IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
Structure analysis and expressions of a novel tetratransmembrane protein, lysosome-associated protein transmembrane 4 B associated with hepatocellular carcinoma
Liu, Xin-Rong1; Zhou, Rou-Li1; Zhang, Qing-Yun2; Zhang, Ye1; Jin, Yue-Ying1; Lin, Ming1; Rui, Jing-An3; Ye, Da-Xiong3
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2004-06-01
10期:11页:1555-1559
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]PRIMARY LIVER-CANCER ; SACCHAROMYCES-CEREVISIAE ; MULTIDRUG-RESISTANCE ; MEMBRANE-PROTEIN ; IDENTIFICATION
英文摘要

AIM: To analyze the structure and expressions of the protein encoded by an HCC-associated novel gene, lysosome-associated protein transmembrane 4 B (LAPTM4B).

METHODS: Primary structure and fundamental characteristics of LAPTM4B protein were analysed with bioinformatics. Expressions of LAPTM4B in HCC tissues and various cell lines were detected using polyclonal antibodies and Western blot.

RESULTS: LAPTM4B encoded two isoforms of proteins with molecular masses 35-ku and 24-ku, respectively. The expression level of LAPTM4B-35 protein in HCC tissues was dramatically upregulated and related to the differentiation status of HCC tissues, and it was also high in some cancer cell lines. Computer analysis showed LAPTM4B was an integral membrane protein with four transmembrane domains. LAPTM4B showed relatively high homology to LAPTM4A and LAPTM5 in various species.

CONCLUSION: LAPTM4B gene encoded two isoforms of tetratransmembrane proteins, LAPTM4B-35 and LAPTM4B-24. The expression of LAPTM4B-35 protein is upregulated and associated with poor differentiation in human HCC tissues, and also at high levels in some cancer cell lines. LAPTM4B is an original and conserved protein.

语种英语
WOS记录号WOS:000208097000005
引用统计
被引频次:43[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67421
专题北京大学基础医学院
北京大学临床肿瘤学院_检验科
作者单位1.Peking Univ, Dept Cell Biol & Genet, Sch Basic Med Sci, Beijing 100083, Peoples R China
2.Peking Univ, Dept Clin Lab, Sch Oncol, Beijing 100037, Peoples R China
3.Beijing Union Med Coll Hosp, Dept Gen Surg Pathol, Beijing 100032, Peoples R China
推荐引用方式
GB/T 7714
Liu, Xin-Rong,Zhou, Rou-Li,Zhang, Qing-Yun,et al. Structure analysis and expressions of a novel tetratransmembrane protein, lysosome-associated protein transmembrane 4 B associated with hepatocellular carcinoma[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2004,10(11):1555-1559.
APA Liu, Xin-Rong.,Zhou, Rou-Li.,Zhang, Qing-Yun.,Zhang, Ye.,Jin, Yue-Ying.,...&Ye, Da-Xiong.(2004).Structure analysis and expressions of a novel tetratransmembrane protein, lysosome-associated protein transmembrane 4 B associated with hepatocellular carcinoma.WORLD JOURNAL OF GASTROENTEROLOGY,10(11),1555-1559.
MLA Liu, Xin-Rong,et al."Structure analysis and expressions of a novel tetratransmembrane protein, lysosome-associated protein transmembrane 4 B associated with hepatocellular carcinoma".WORLD JOURNAL OF GASTROENTEROLOGY 10.11(2004):1555-1559.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, Xin-Rong]的文章
[Zhou, Rou-Li]的文章
[Zhang, Qing-Yun]的文章
百度学术
百度学术中相似的文章
[Liu, Xin-Rong]的文章
[Zhou, Rou-Li]的文章
[Zhang, Qing-Yun]的文章
必应学术
必应学术中相似的文章
[Liu, Xin-Rong]的文章
[Zhou, Rou-Li]的文章
[Zhang, Qing-Yun]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。