北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 期刊论文
学科主题: 基础医学
题名:
Structure analysis and expressions of a novel tetratransmembrane protein, lysosome-associated protein transmembrane 4 B associated with hepatocellular carcinoma
作者: Liu, Xin-Rong1; Zhou, Rou-Li1; Zhang, Qing-Yun2; Zhang, Ye1; Jin, Yue-Ying1; Lin, Ming1; Rui, Jing-An3; Ye, Da-Xiong3
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2004-06-01
卷: 10, 期:11, 页:1555-1559
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: PRIMARY LIVER-CANCER ; SACCHAROMYCES-CEREVISIAE ; MULTIDRUG-RESISTANCE ; MEMBRANE-PROTEIN ; IDENTIFICATION
英文摘要:

AIM: To analyze the structure and expressions of the protein encoded by an HCC-associated novel gene, lysosome-associated protein transmembrane 4 B (LAPTM4B).

METHODS: Primary structure and fundamental characteristics of LAPTM4B protein were analysed with bioinformatics. Expressions of LAPTM4B in HCC tissues and various cell lines were detected using polyclonal antibodies and Western blot.

RESULTS: LAPTM4B encoded two isoforms of proteins with molecular masses 35-ku and 24-ku, respectively. The expression level of LAPTM4B-35 protein in HCC tissues was dramatically upregulated and related to the differentiation status of HCC tissues, and it was also high in some cancer cell lines. Computer analysis showed LAPTM4B was an integral membrane protein with four transmembrane domains. LAPTM4B showed relatively high homology to LAPTM4A and LAPTM5 in various species.

CONCLUSION: LAPTM4B gene encoded two isoforms of tetratransmembrane proteins, LAPTM4B-35 and LAPTM4B-24. The expression of LAPTM4B-35 protein is upregulated and associated with poor differentiation in human HCC tissues, and also at high levels in some cancer cell lines. LAPTM4B is an original and conserved protein.

语种: 英语
所属项目编号: H020220020310
项目资助者: 248 Major R&amp ; D Program of Beijing ; Education, Ministry of Education, China
WOS记录号: WOS:000208097000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67421
Appears in Collections:基础医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Cell Biol & Genet, Sch Basic Med Sci, Beijing 100083, Peoples R China
2.Peking Univ, Dept Clin Lab, Sch Oncol, Beijing 100037, Peoples R China
3.Beijing Union Med Coll Hosp, Dept Gen Surg Pathol, Beijing 100032, Peoples R China

Recommended Citation:
Liu, Xin-Rong,Zhou, Rou-Li,Zhang, Qing-Yun,et al. Structure analysis and expressions of a novel tetratransmembrane protein, lysosome-associated protein transmembrane 4 B associated with hepatocellular carcinoma[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2004,10(11):1555-1559.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Xin-Rong]'s Articles
[Zhou, Rou-Li]'s Articles
[Zhang, Qing-Yun]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Xin-Rong]‘s Articles
[Zhou, Rou-Li]‘s Articles
[Zhang, Qing-Yun]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace