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Comparison of carcinoembryonic antigen prognostic value in serum and tumour tissue of patients with colorectal cancer
Li, M.1; Li, J. -Y.2; Zhao, A. -L.2; He, J. -S.2; Zhou, L. -X.2; Li, Y. -A.2; Gu, J.1
关键词Colorectal cancer prognosis carcinoembryonic antigen
刊名COLORECTAL DISEASE
2009-03-01
DOI10.1111/j.1463-1318.2008.01591.x
11期:3页:276-281
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Surgery
研究领域[WOS]Gastroenterology & Hepatology ; Surgery
关键词[WOS]HUMAN DIGESTIVE SYSTEM ; COLON-CANCER ; MULTIVARIATE-ANALYSIS ; GENE FAMILY ; LARGE-BOWEL ; CEA LEVELS ; CARCINOMA ; PLASMA ; LEVEL ; STAGE
英文摘要

Carcinoembryonic antigen (CEA) in the serum and the tumour tissue of colorectal cancer (CRC) patients is the most commonly used tumour marker for the diagnosis and evaluation of prognosis or recurrence after treatment, but the role remains controversial. The objective of this study was to compare the prognostic value of CEA both in serum and tumour tissue in CRC.

A total of 173 patients with CRC in stages I-III were retrospectively assessed with the endpoint of recurrence or metastasis after curative operation. CEA was assessed both in serum and tumour tissue.

37.0% (64/173) patients had a high level of CEA in serum (S-CEA) while 39.3% (68/173) had high CEA in tumour tissue (T-CEA). There were no significant differences in clinico-pathological features between the low and high S-CEA or T-CEA groups. The high S-CEA group had a worse prognosis than the low S-CEA group but the difference was not significant. The high T-CEA group had a significantly poorer prognosis than the low T-CEA group (P = 0.028) in the univariate analysis. The multivariate analysis demonstrated that the T-CEA was an independent prognosis factor in CRC. Because many factors would affect the concentration of S-CEA, there was no correlation between S-CEA and T-CEA directly.

Our study suggests that a high T-CEA concentration may be a useful and independent predictor for poor outcome after surgery in CRC patients. It may be stronger than a high preoperative serum CEA level.

语种英语
WOS记录号WOS:000263352300010
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67425
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_结直肠肿瘤外科
作者单位1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Gastrointestinal Surg Unit, Beijing 100871, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Pathol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, M.,Li, J. -Y.,Zhao, A. -L.,et al. Comparison of carcinoembryonic antigen prognostic value in serum and tumour tissue of patients with colorectal cancer[J]. COLORECTAL DISEASE,2009,11(3):276-281.
APA Li, M..,Li, J. -Y..,Zhao, A. -L..,He, J. -S..,Zhou, L. -X..,...&Gu, J..(2009).Comparison of carcinoembryonic antigen prognostic value in serum and tumour tissue of patients with colorectal cancer.COLORECTAL DISEASE,11(3),276-281.
MLA Li, M.,et al."Comparison of carcinoembryonic antigen prognostic value in serum and tumour tissue of patients with colorectal cancer".COLORECTAL DISEASE 11.3(2009):276-281.
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