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学科主题: 临床医学
题名:
Comparison of carcinoembryonic antigen prognostic value in serum and tumour tissue of patients with colorectal cancer
作者: Li, M.1; Li, J. -Y.2; Zhao, A. -L.2; He, J. -S.2; Zhou, L. -X.2; Li, Y. -A.2; Gu, J.1
关键词: Colorectal cancer ; prognosis ; carcinoembryonic antigen
刊名: COLORECTAL DISEASE
发表日期: 2009-03-01
DOI: 10.1111/j.1463-1318.2008.01591.x
卷: 11, 期:3, 页:276-281
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Surgery
研究领域[WOS]: Gastroenterology & Hepatology ; Surgery
关键词[WOS]: HUMAN DIGESTIVE SYSTEM ; COLON-CANCER ; MULTIVARIATE-ANALYSIS ; GENE FAMILY ; LARGE-BOWEL ; CEA LEVELS ; CARCINOMA ; PLASMA ; LEVEL ; STAGE
英文摘要:

Carcinoembryonic antigen (CEA) in the serum and the tumour tissue of colorectal cancer (CRC) patients is the most commonly used tumour marker for the diagnosis and evaluation of prognosis or recurrence after treatment, but the role remains controversial. The objective of this study was to compare the prognostic value of CEA both in serum and tumour tissue in CRC.

A total of 173 patients with CRC in stages I-III were retrospectively assessed with the endpoint of recurrence or metastasis after curative operation. CEA was assessed both in serum and tumour tissue.

37.0% (64/173) patients had a high level of CEA in serum (S-CEA) while 39.3% (68/173) had high CEA in tumour tissue (T-CEA). There were no significant differences in clinico-pathological features between the low and high S-CEA or T-CEA groups. The high S-CEA group had a worse prognosis than the low S-CEA group but the difference was not significant. The high T-CEA group had a significantly poorer prognosis than the low T-CEA group (P = 0.028) in the univariate analysis. The multivariate analysis demonstrated that the T-CEA was an independent prognosis factor in CRC. Because many factors would affect the concentration of S-CEA, there was no correlation between S-CEA and T-CEA directly.

Our study suggests that a high T-CEA concentration may be a useful and independent predictor for poor outcome after surgery in CRC patients. It may be stronger than a high preoperative serum CEA level.

语种: 英语
WOS记录号: WOS:000263352300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67425
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Gastrointestinal Surg Unit, Beijing 100871, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Pathol, Beijing 100871, Peoples R China

Recommended Citation:
Li, M.,Li, J. -Y.,Zhao, A. -L.,et al. Comparison of carcinoembryonic antigen prognostic value in serum and tumour tissue of patients with colorectal cancer[J]. COLORECTAL DISEASE,2009,11(3):276-281.
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