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学科主题: 临床医学
题名:
Effects of adrenomedullin, C-type natriuretic peptide, and parathyroid hormone-related peptide on calcification in cultured rat vascular smooth muscle cells
作者: Huang, ZY; Li, JX; Jiang, ZS; Qi, YF; Tang, CS; Du, JB
关键词: vascular calcification ; vascular smooth muscle cells ; adrenomedullin ; C-type natriuretic peptide ; parathyroid hormone
刊名: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
发表日期: 2003-07-01
卷: 42, 期:1, 页:89-97
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Pharmacology & Pharmacy
研究领域[WOS]: Cardiovascular System & Cardiology ; Pharmacology & Pharmacy
关键词[WOS]: ARTERIAL CALCIFICATION ; OSTEOBLASTIC DIFFERENTIATION ; OSTEOPONTIN ; INHIBITION ; GENE
英文摘要:

To clarify the regulating mechanism of vascular calcification, the investigators observed the effects of three vasoactive peptides, adrenomedullin (ADM), C-type natriuretic peptide (CNP), and parathyroid hormone-related peptide (PTHrP) on calcification in rat vascular smooth muscle cells (VSMCs). Beta-glycerophosphate stimulated growth and calcification in VSMCs. Adrenomedullin and CNP lowered beta-glycerophosphate-induced increase in VSMC growth. All three vasoactive peptides attenuated the increases of Ca-45 accumulation, calcium content, and alkaline phosphatase activity in calcified VSMCs. As for comparing the inhibitory effects, the strongest was PTHrP. Both ADM and PTHrP increased cyclic adenosine monophosphate (cAMP) content in calcified VSMCs, but CNP up-regulated cyclic guanosine monophosphate (cGMP) content. The PKA inhibitor PKAI completely reversed the inhibition of ADM on cell growth and all inhibitory effects of PTHrP on the parameters of calcification. The PKG inhibitor H8, however, strongly antagonized all the inhibitory effects of CNP on calcification. These data suggested that beta-glycerophosphate-induced calcification in VSMCs was inhibited by ADM, CNP, and PTHrP. Adrenomedullin and PTHrP inhibited VSMC calcification partially through the cAMP/PKA pathway, whereas CNP inhibited VSMC calcification through the cGMP/PKG pathway. This study could be of help in understanding the pathogenesis of vascular calcification, and providing new target for clinical treatment of cardiovascular diseases associated with vascular calcification.

语种: 英语
WOS记录号: WOS:000183897600014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67430
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100083, Peoples R China

Recommended Citation:
Huang, ZY,Li, JX,Jiang, ZS,et al. Effects of adrenomedullin, C-type natriuretic peptide, and parathyroid hormone-related peptide on calcification in cultured rat vascular smooth muscle cells[J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY,2003,42(1):89-97.
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