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Effects of adrenomedullin, C-type natriuretic peptide, and parathyroid hormone-related peptide on calcification in cultured rat vascular smooth muscle cells
Huang, ZY; Li, JX; Jiang, ZS; Qi, YF; Tang, CS; Du, JB
关键词vascular calcification vascular smooth muscle cells adrenomedullin C-type natriuretic peptide parathyroid hormone
刊名JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
2003-07-01
42期:1页:89-97
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Pharmacology & Pharmacy
研究领域[WOS]Cardiovascular System & Cardiology ; Pharmacology & Pharmacy
关键词[WOS]ARTERIAL CALCIFICATION ; OSTEOBLASTIC DIFFERENTIATION ; OSTEOPONTIN ; INHIBITION ; GENE
英文摘要

To clarify the regulating mechanism of vascular calcification, the investigators observed the effects of three vasoactive peptides, adrenomedullin (ADM), C-type natriuretic peptide (CNP), and parathyroid hormone-related peptide (PTHrP) on calcification in rat vascular smooth muscle cells (VSMCs). Beta-glycerophosphate stimulated growth and calcification in VSMCs. Adrenomedullin and CNP lowered beta-glycerophosphate-induced increase in VSMC growth. All three vasoactive peptides attenuated the increases of Ca-45 accumulation, calcium content, and alkaline phosphatase activity in calcified VSMCs. As for comparing the inhibitory effects, the strongest was PTHrP. Both ADM and PTHrP increased cyclic adenosine monophosphate (cAMP) content in calcified VSMCs, but CNP up-regulated cyclic guanosine monophosphate (cGMP) content. The PKA inhibitor PKAI completely reversed the inhibition of ADM on cell growth and all inhibitory effects of PTHrP on the parameters of calcification. The PKG inhibitor H8, however, strongly antagonized all the inhibitory effects of CNP on calcification. These data suggested that beta-glycerophosphate-induced calcification in VSMCs was inhibited by ADM, CNP, and PTHrP. Adrenomedullin and PTHrP inhibited VSMC calcification partially through the cAMP/PKA pathway, whereas CNP inhibited VSMC calcification through the cGMP/PKG pathway. This study could be of help in understanding the pathogenesis of vascular calcification, and providing new target for clinical treatment of cardiovascular diseases associated with vascular calcification.

语种英语
WOS记录号WOS:000183897600014
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67430
专题北京大学第一临床医学院_儿科
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100083, Peoples R China
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GB/T 7714
Huang, ZY,Li, JX,Jiang, ZS,et al. Effects of adrenomedullin, C-type natriuretic peptide, and parathyroid hormone-related peptide on calcification in cultured rat vascular smooth muscle cells[J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY,2003,42(1):89-97.
APA Huang, ZY,Li, JX,Jiang, ZS,Qi, YF,Tang, CS,&Du, JB.(2003).Effects of adrenomedullin, C-type natriuretic peptide, and parathyroid hormone-related peptide on calcification in cultured rat vascular smooth muscle cells.JOURNAL OF CARDIOVASCULAR PHARMACOLOGY,42(1),89-97.
MLA Huang, ZY,et al."Effects of adrenomedullin, C-type natriuretic peptide, and parathyroid hormone-related peptide on calcification in cultured rat vascular smooth muscle cells".JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 42.1(2003):89-97.
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