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学科主题: 药学
题名:
Synthesis of aminodisaccharide-nucleoside conjugates for RNA binding
作者: Cai, Li; Li, Qin; Ren, Bo; Yang, Zhen-Jun; Zhang, Liang-Ren; Zhang, Li-He
刊名: TETRAHEDRON
发表日期: 2007-08-20
DOI: 10.1016/j.tet.2007.06.002
卷: 63, 期:34, 页:8135-8144
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: SURFACE-PLASMON RESONANCE ; AMINOGLYCOSIDE ANTIBIOTICS ; CRYSTAL-STRUCTURE ; RIBOSOMAL-RNA ; HAIRPIN LOOPS ; A-SITE ; SUBUNIT
英文摘要:

Two types of aminodisaccharide-nucleoside conjugates were synthesized by the condensation of azidodisaccharide and nucleoside using aliphatic diamine as a linker. The corresponding azidodisaccharides could be yielded from neamine in good yield. The binding properties to 16S RNA of these conjugates were evaluated by SPR. It was found that the nucleobase played a significant role in the binding of these conjugates to 16S RNA and a shorter linker between the aminodisaccharide and nucleoside was favorable for 16S RNA binding. (c) 2007 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000252083800009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67438
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Natl & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Cai, Li,Li, Qin,Ren, Bo,et al. Synthesis of aminodisaccharide-nucleoside conjugates for RNA binding[J]. TETRAHEDRON,2007,63(34):8135-8144.
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