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Synthesis of aminodisaccharide-nucleoside conjugates for RNA binding
Cai, Li; Li, Qin; Ren, Bo; Yang, Zhen-Jun; Zhang, Liang-Ren; Zhang, Li-He
刊名TETRAHEDRON
2007-08-20
DOI10.1016/j.tet.2007.06.002
63期:34页:8135-8144
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]SURFACE-PLASMON RESONANCE ; AMINOGLYCOSIDE ANTIBIOTICS ; CRYSTAL-STRUCTURE ; RIBOSOMAL-RNA ; HAIRPIN LOOPS ; A-SITE ; SUBUNIT
英文摘要

Two types of aminodisaccharide-nucleoside conjugates were synthesized by the condensation of azidodisaccharide and nucleoside using aliphatic diamine as a linker. The corresponding azidodisaccharides could be yielded from neamine in good yield. The binding properties to 16S RNA of these conjugates were evaluated by SPR. It was found that the nucleobase played a significant role in the binding of these conjugates to 16S RNA and a shorter linker between the aminodisaccharide and nucleoside was favorable for 16S RNA binding. (c) 2007 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000252083800009
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67438
专题北京大学药学院
北京大学药学院_药物化学系
北京大学第一临床医学院_药剂科
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Natl & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Cai, Li,Li, Qin,Ren, Bo,et al. Synthesis of aminodisaccharide-nucleoside conjugates for RNA binding[J]. TETRAHEDRON,2007,63(34):8135-8144.
APA Cai, Li,Li, Qin,Ren, Bo,Yang, Zhen-Jun,Zhang, Liang-Ren,&Zhang, Li-He.(2007).Synthesis of aminodisaccharide-nucleoside conjugates for RNA binding.TETRAHEDRON,63(34),8135-8144.
MLA Cai, Li,et al."Synthesis of aminodisaccharide-nucleoside conjugates for RNA binding".TETRAHEDRON 63.34(2007):8135-8144.
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