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Co-expression of CXCR4 and CD133 proteins is associated with poor prognosis in stage II-III colon cancer patients
Zhang, Nian-Hua1,2; Li, Jie3; Li, Yin4; Zhang, Xin-Tao5; Liao, Wen-Ting6,7,8; Zhang, Jun-Yi1; Li, Rung1; Luo, Rong-Cheng1
关键词CXCR4 CD133 colon cancer immunohistochemistry
刊名EXPERIMENTAL AND THERAPEUTIC MEDICINE
2012-06-01
DOI10.3892/etm.2012.527
3期:6页:973-982
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]CHEMOKINE RECEPTOR CXCR4 ; LYMPH-NODE METASTASIS ; STEM-CELLS ; COLORECTAL-CANCER ; HEMATOPOIETIC STEM ; FACTOR-1/CXCR4 AXIS ; PANCREATIC-CANCER ; ESOPHAGEAL CANCER ; TUMOR PROGRESSION ; EPITHELIAL-CELLS
英文摘要

Although CXCR4 and CD133 have been implicated in the metastatic process of malignant tumors, the clinicopathological significance of their expression in human colon cancer is not fully understood. The present study aimed to examine the expression of the CXCR4 and CD133 proteins in cases of stage II or III colon cancer and the related lymph nodes and to investigate the clinical and prognostic significance of these proteins in colon cancer. Immunohistochemical analysis was performed to examine CXCR4 and CD133 protein expression in paraffin-embedded stage II or III primary colon cancer tissues and matched lymph nodes. The correlation between the expression of the two proteins and clinicopathological parameters and the patient 5-year survival was analyzed. CXCR4 expression was detected in 74 of the 125 tumors (59.2%) and CD133 expression was detected in 45(36.0%). The co-expression of CXCR4 and CD133 (both CXCR4 and CM 33 were positive) was detected in 29 of the 125 tumors (23.2%). Compared with the other combinations, the co-expression of the CXCR4 and CD133 proteins was significantly associated with American Joint Committee on Cancer (AJCC) stage (P=0.029) and lymph node status (P=0.020). Log-rank analysis revealed that AJCC stage (P=0.014), lymph node status (P=0.011), CXCR4 expression (P=0.023), CD133 expression (P=0.034) and the co-expression of the CXCR4 and CD 133 proteins (P=0.003) were significant prognostic indicators for the overall survival of patients. The results of the present study show that the co-expression of the CXCR4 and CD133 proteins is a risk factor for poor overall survival in stage II or III colon cancer patients, indicating that the co-expression of the CXCR4 and CD133 proteins contributes to the progression of colon cancer.

语种英语
WOS记录号WOS:000304182400010
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67441
专题北京大学深圳医院_运动医学与康复科
作者单位1.So Med Univ, Nanfang Hosp, Dept Oncol, Guangzhou 510515, Guangdong, Peoples R China
2.Guangdong Second Prov Tradit Chinese Med Hosp, Dept Oncol, Guangzhou 510095, Guangdong, Peoples R China
3.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Vasc Surg, Guangzhou 510080, Guangdong, Peoples R China
4.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Guangzhou 510080, Guangdong, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Sports Med, Shenzhen 518036, Peoples R China
6.So Med Univ, Sch Basic Med Sci, Dept Pathol, Guangzhou 510515, Guangdong, Peoples R China
7.So Med Univ, Nanfang Hosp, Dept Pathol, Guangzhou 510515, Guangdong, Peoples R China
8.Guangdong Prov Key Lab Mol Tumour Pathol, Guangzhou 510515, Guangdong, Peoples R China
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Zhang, Nian-Hua,Li, Jie,Li, Yin,et al. Co-expression of CXCR4 and CD133 proteins is associated with poor prognosis in stage II-III colon cancer patients[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2012,3(6):973-982.
APA Zhang, Nian-Hua.,Li, Jie.,Li, Yin.,Zhang, Xin-Tao.,Liao, Wen-Ting.,...&Luo, Rong-Cheng.(2012).Co-expression of CXCR4 and CD133 proteins is associated with poor prognosis in stage II-III colon cancer patients.EXPERIMENTAL AND THERAPEUTIC MEDICINE,3(6),973-982.
MLA Zhang, Nian-Hua,et al."Co-expression of CXCR4 and CD133 proteins is associated with poor prognosis in stage II-III colon cancer patients".EXPERIMENTAL AND THERAPEUTIC MEDICINE 3.6(2012):973-982.
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