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学科主题: 临床医学
题名:
Co-expression of CXCR4 and CD133 proteins is associated with poor prognosis in stage II-III colon cancer patients
作者: Zhang, Nian-Hua1,2; Li, Jie3; Li, Yin4; Zhang, Xin-Tao5; Liao, Wen-Ting6,7,8; Zhang, Jun-Yi1; Li, Rung1; Luo, Rong-Cheng1
关键词: CXCR4 ; CD133 ; colon cancer ; immunohistochemistry
刊名: EXPERIMENTAL AND THERAPEUTIC MEDICINE
发表日期: 2012-06-01
DOI: 10.3892/etm.2012.527
卷: 3, 期:6, 页:973-982
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: CHEMOKINE RECEPTOR CXCR4 ; LYMPH-NODE METASTASIS ; STEM-CELLS ; COLORECTAL-CANCER ; HEMATOPOIETIC STEM ; FACTOR-1/CXCR4 AXIS ; PANCREATIC-CANCER ; ESOPHAGEAL CANCER ; TUMOR PROGRESSION ; EPITHELIAL-CELLS
英文摘要:

Although CXCR4 and CD133 have been implicated in the metastatic process of malignant tumors, the clinicopathological significance of their expression in human colon cancer is not fully understood. The present study aimed to examine the expression of the CXCR4 and CD133 proteins in cases of stage II or III colon cancer and the related lymph nodes and to investigate the clinical and prognostic significance of these proteins in colon cancer. Immunohistochemical analysis was performed to examine CXCR4 and CD133 protein expression in paraffin-embedded stage II or III primary colon cancer tissues and matched lymph nodes. The correlation between the expression of the two proteins and clinicopathological parameters and the patient 5-year survival was analyzed. CXCR4 expression was detected in 74 of the 125 tumors (59.2%) and CD133 expression was detected in 45(36.0%). The co-expression of CXCR4 and CD133 (both CXCR4 and CM 33 were positive) was detected in 29 of the 125 tumors (23.2%). Compared with the other combinations, the co-expression of the CXCR4 and CD133 proteins was significantly associated with American Joint Committee on Cancer (AJCC) stage (P=0.029) and lymph node status (P=0.020). Log-rank analysis revealed that AJCC stage (P=0.014), lymph node status (P=0.011), CXCR4 expression (P=0.023), CD133 expression (P=0.034) and the co-expression of the CXCR4 and CD 133 proteins (P=0.003) were significant prognostic indicators for the overall survival of patients. The results of the present study show that the co-expression of the CXCR4 and CD133 proteins is a risk factor for poor overall survival in stage II or III colon cancer patients, indicating that the co-expression of the CXCR4 and CD133 proteins contributes to the progression of colon cancer.

语种: 英语
所属项目编号: 10251051501000008
项目资助者: Guangdong Natural Science Foundation
WOS记录号: WOS:000304182400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67441
Appears in Collections:北京大学深圳医院_运动医学与康复科_期刊论文

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作者单位: 1.So Med Univ, Nanfang Hosp, Dept Oncol, Guangzhou 510515, Guangdong, Peoples R China
2.Guangdong Second Prov Tradit Chinese Med Hosp, Dept Oncol, Guangzhou 510095, Guangdong, Peoples R China
3.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Vasc Surg, Guangzhou 510080, Guangdong, Peoples R China
4.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Guangzhou 510080, Guangdong, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Sports Med, Shenzhen 518036, Peoples R China
6.So Med Univ, Sch Basic Med Sci, Dept Pathol, Guangzhou 510515, Guangdong, Peoples R China
7.So Med Univ, Nanfang Hosp, Dept Pathol, Guangzhou 510515, Guangdong, Peoples R China
8.Guangdong Prov Key Lab Mol Tumour Pathol, Guangzhou 510515, Guangdong, Peoples R China

Recommended Citation:
Zhang, Nian-Hua,Li, Jie,Li, Yin,et al. Co-expression of CXCR4 and CD133 proteins is associated with poor prognosis in stage II-III colon cancer patients[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2012,3(6):973-982.
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