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学科主题基础医学
Management of Hepatitis E Virus (HEV) Zoonotic Transmission: Protection of Rabbits against HEV Challenge following Immunization with HEV 239 Vaccine
Liu, Peng; Du, Ren Jie; Wang, Ling; Han, Jian; Liu, Lin; Zhang, Yu Lin; Xia, Jun Ke; Lu, Feng Min; Zhuang, Hui
刊名PLOS ONE
2014-01-30
DOI10.1371/journal.pone.0087600
9期:1
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]CROSS-SPECIES INFECTION ; UNITED-STATES ; GENOTYPES 1 ; CHINA ; ANTIGENICITY ; PREVALENCE ; COUNTRIES ; STRAINS ; HUMANS ; SWINE
英文摘要

Hepatitis E virus (HEV) constitutes a significant health burden worldwide, with an estimated approximately 33% of the world′s population exposed to the pathogen. The recent licensed HEV 239 vaccine in China showed excellent protective efficacy against HEV of genotypes 1 and 4 in the general population and pregnant women. Because hepatitis E is a zoonosis, it is also necessary to ascertain whether this vaccine can serve to manage animal sources of human HEV infection. To test the efficacy of the HEV 239 vaccine in protecting animal reservoirs of HEV against HEV infection, twelve specific-pathogen-free (SPF) rabbits were divided randomly into two groups of 6 animals and inoculated intramuscularly with HEV 239 and placebo (PBS). All animals were challenged intravenously with swine HEV of genotype 4 or rabbit HEV seven weeks after the initial immunization. The course of infection was monitored for 10 weeks by serum ALT levels, duration of viremia and fecal virus excretion and HEV antibody responses. All rabbits immunized with HEV 239 developed high titers of anti-HEV and no signs of HEV infection were observed throughout the experiment, while rabbits inoculated with PBS developed viral hepatitis following challenge, with liver enzyme elevations, viremia, and fecal virus shedding. Our data indicated that the HEV 239 vaccine is highly immunogenic for rabbits and that it can completely protect rabbits against homologous and heterologous HEV infections. These findings could facilitate the prevention of food-borne sporadic HEV infection in both developing and industrialized countries.

语种英语
WOS记录号WOS:000330617100099
项目编号81271827 ; 20120001110098
资助机构National Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67444
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
北京大学药学院
医学人文研究院/公共教学部_哲学与社会科学系
作者单位Peking Univ, Sch Basic Med Sci, Dept Microbiol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Liu, Peng,Du, Ren Jie,Wang, Ling,et al. Management of Hepatitis E Virus (HEV) Zoonotic Transmission: Protection of Rabbits against HEV Challenge following Immunization with HEV 239 Vaccine[J]. PLOS ONE,2014,9(1).
APA Liu, Peng.,Du, Ren Jie.,Wang, Ling.,Han, Jian.,Liu, Lin.,...&Zhuang, Hui.(2014).Management of Hepatitis E Virus (HEV) Zoonotic Transmission: Protection of Rabbits against HEV Challenge following Immunization with HEV 239 Vaccine.PLOS ONE,9(1).
MLA Liu, Peng,et al."Management of Hepatitis E Virus (HEV) Zoonotic Transmission: Protection of Rabbits against HEV Challenge following Immunization with HEV 239 Vaccine".PLOS ONE 9.1(2014).
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