学科主题 | 临床医学 |
Long-Term Telbivudine Treatment Results in Resolution of Liver Inflammation and Fibrosis in Patients with Chronic Hepatitis B | |
Hou, Jin-Lin1; Xu, Daozheng2; Shi, Guangfeng3; Wan, Mobin4; Goodman, Zachary5; Tan, Deming6; Xie, Qing7; Chen, Chengwei8; Wei, Lai9; Niu, Junqi10; Wang, Qinhuan11; Ren, Hong12; Wang, Yuming13; Jia, Jidong14; Bao, Weibin15; Dong, Yuhong16; Trylesinski, Aldo16; Naoumov, Nikolai V.16 | |
关键词 | Chronic hepatitis B Ishak fibrosis score Knodell necroinflammatory score Liver biopsy Telbivudine |
刊名 | ADVANCES IN THERAPY
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2015-08-01 | |
DOI | 10.1007/s12325-015-0232-2 |
卷 | 32期:8页:727-741 |
收录类别 | SCI |
文章类型 | Article |
WOS标题词 | Science & Technology |
类目[WOS] | Medicine, Research & Experimental ; Pharmacology & Pharmacy |
资助者 | Novartis ; National Science and Technology Major Project ; Novartis Pharma AG ; Novartis ; National Science and Technology Major Project ; Novartis Pharma AG |
研究领域[WOS] | Research & Experimental Medicine ; Pharmacology & Pharmacy |
关键词[WOS] | SUSTAINED VIROLOGICAL RESPONSE ; TENOFOVIR DISOPROXIL FUMARATE ; HEPATOCELLULAR-CARCINOMA ; VIRAL LOAD ; TRANSIENT ELASTOGRAPHY ; LAMIVUDINE THERAPY ; ADEFOVIR DIPIVOXIL ; POSITIVE PATIENTS ; DNA LEVEL ; CIRRHOSIS |
英文摘要 | The long-term goal of chronic hepatitis B (CHB) treatment is improvement of liver disease and prevention of cirrhosis. The aim of this study was to assess whether prolonged telbivudine treatment improves liver inflammation and fibrosis. The primary objective was to evaluate the proportion of patients with absence/minimal inflammation (Knodell necroinflammatory score a parts per thousand currency sign3) on liver biopsy at Year 5. Fifty-seven patients aged 16-70 years with a clinical history of CHB and active viral replication (38 hepatitis B e antigen [HBeAg] positive and 19 HBeAg negative) were followed for 6 years: 33 received telbivudine 600 mg/day continuously for 5 years; 24 received lamivudine 100 mg/day for 2 years and then telbivudine for 3 years. Liver biopsies were taken pre-treatment and after 5 years of treatment. At baseline, mean (standard deviation) serum hepatitis B virus (HBV) DNA load was 8.5 (1.7) log(10) copies/mL, Knodell necroinflammatory score was 7.6 (2.9), and Ishak fibrosis score was 2.2 (1.1). After antiviral treatment (median duration: 261 weeks), liver histology improved with increased proportions of patients with absence/minimal liver inflammation (Knodell necroinflammatory score a parts per thousand currency sign3), from 16% (9/57) at baseline to 98% (56/57), and absence/minimal fibrosis (Ishak score a parts per thousand currency sign1), from 25% (14/57) at baseline to 84% (48/57). At Year 5, HBV DNA load was < 300 copies/mL for all patients; cumulative HBeAg loss and seroconversion rates were 88% and 77%, respectively. At Year 6, 95% of patients with abnormal baseline glomerular filtration rate (60-90 mL/min/1.73 m(2)) improved to normal GFR (> 90 mL/min/1.73 m(2)). Long-term telbivudine treatment with profound and durable viral suppression significantly improved liver histology, thus achieving the long-term goals of CHB treatment. FibroScan(A (R)) results after 5 and 6 years of treatment (in almost 20% of patients) were consistent with this information. Novartis and National Science and Technology Major Project (2012ZX10002003). ClinicalTrials.gov # NCT00877149. |
语种 | 英语 |
所属项目编号 | 2012ZX10002003 |
资助者 | Novartis ; National Science and Technology Major Project ; Novartis Pharma AG ; Novartis ; National Science and Technology Major Project ; Novartis Pharma AG |
WOS记录号 | WOS:000361437000002 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/67448 |
Collection | 北京大学第二临床医学院 |
作者单位 | 1.Nanjing Mil Area, Shanghai Liver Dis Res Ctr, Shanghai, Peoples R China 2.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China 3.1 Hosp, Changchun, Peoples R China 4.First Hosp Peking, Beijing, Peoples R China 5.Xi Nan Hosp, Chongqing, Peoples R China 6.Beijing Friendship Hosp, Beijing, Peoples R China 7.Novartis Pharma Corp, E Hanover, NJ USA 8.Xiangya Hosp, Changsha, Hunan, Peoples R China 9.Novartis Pharma AG, Basel, Switzerland 10.Beijing Ditan Hosp, Beijing, Peoples R China 11.Shanghai Changhai Hosp, Shanghai, Peoples R China 12.Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA USA 13.Southern Med Univ, Nanfang Hosp, Hepatol Unit, Dept Infect Dis, Guangzhou 510515, Guangdong, Peoples R China 14.Fu Dan Univ, Huashan Hosp, Dept Infect Dis, Shanghai, Peoples R China 15.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Shanghai 200030, Peoples R China 16.Chongqing Med Univ, Affiliated Hosp 2, Chongqing, Peoples R China |
Recommended Citation GB/T 7714 | Hou, Jin-Lin,Xu, Daozheng,Shi, Guangfeng,et al. Long-Term Telbivudine Treatment Results in Resolution of Liver Inflammation and Fibrosis in Patients with Chronic Hepatitis B[J]. ADVANCES IN THERAPY,2015,32(8):727-741. |
APA | Hou, Jin-Lin.,Xu, Daozheng.,Shi, Guangfeng.,Wan, Mobin.,Goodman, Zachary.,...&Naoumov, Nikolai V..(2015).Long-Term Telbivudine Treatment Results in Resolution of Liver Inflammation and Fibrosis in Patients with Chronic Hepatitis B.ADVANCES IN THERAPY,32(8),727-741. |
MLA | Hou, Jin-Lin,et al."Long-Term Telbivudine Treatment Results in Resolution of Liver Inflammation and Fibrosis in Patients with Chronic Hepatitis B".ADVANCES IN THERAPY 32.8(2015):727-741. |
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