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学科主题: 口腔医学
题名:
T Cells Are Required for Orthodontic Tooth Movement
作者: Yan, Y.1,2; Liu, F.1,2; Kou, X.1,2; Liu, D.1,2; Yang, R.1,2; Wang, X.1,2; Song, Y.1,2; He, D.1,2; Gan, Y.3; Zhou, Y.1,2
关键词: orthodontics ; bone remodeling ; biomechanics ; inflammation ; immunity ; cytokines
刊名: JOURNAL OF DENTAL RESEARCH
发表日期: 2015-10-01
DOI: 10.1177/0022034515595003
卷: 94, 期:10, 页:1463-1470
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: NECROSIS-FACTOR-ALPHA ; PERIODONTAL-LIGAMENT CELLS ; HUMAN GINGIVAL SULCUS ; IFN-GAMMA ; BONE LOSS ; ROOT RESORPTION ; TNF-ALPHA ; ACTIVATION ; OSTEOCLASTOGENESIS ; EXPRESSION
英文摘要:

The immune system plays a pivotal role during bone remodeling process. Orthodontic tooth movement (OTM) induces local inflammation in periodontium, but whether systemic immune response is involved in OTM remains unknown. In this study, we show that tooth movement distance was significantly reduced in T-cell-deficient immunocompromised mice compared with wild-type (WT) mice. Intravenous infusion of allogeneic T cells to the immunocompromised mice rescued the OTM distance. Correspondingly, increased numbers of tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts were detected around the alveolar bone after OTM in WT mice but were barely detected in immunocompromised mice. Moreover, intravenous infusion of T cells rescued the number of TRAP-positive osteoclasts in the OTM area of the immunocompromised mice, thus suggesting T cells are required for OTM. We then reveal that OTM induced a significant elevation of type 1 T helper cell (Th1) cytokines tumor necrosis factor- (TNF-) and interferon- (IFN-) around periodontal tissue in WT but not in immunocompromised mice. Infusion of T cells could increase the levels of TNF- and IFN- in periodontal tissues of immunocompromised mice. More interestingly, intraperitoneal injection of TNF- inhibitor etanercept significantly reduced the distance of OTM in T-cell-infused immunocompromised mice. In summary, this study demonstrates a previously unrecognized mechanism that T cells are required for OTM depending on Th1-associated cytokines.

语种: 英语
所属项目编号: 2013DFB30360 ; 81470717 ; 81300897
项目资助者: International S&amp ; T cooperation program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000361819400019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67454
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Ctr Craniofacial Stem Cell Res & Regenerat, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Ctr Temporomandibular Disorders & Orofacial Pain, Beijing 100081, Peoples R China

Recommended Citation:
Yan, Y.,Liu, F.,Kou, X.,et al. T Cells Are Required for Orthodontic Tooth Movement[J]. JOURNAL OF DENTAL RESEARCH,2015,94(10):1463-1470.
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