IR@PKUHSC  > 北京大学口腔医学院  > 牙周科
学科主题口腔医学
T Cells Are Required for Orthodontic Tooth Movement
Yan, Y.1,2; Liu, F.1,2; Kou, X.1,2; Liu, D.1,2; Yang, R.1,2; Wang, X.1,2; Song, Y.1,2; He, D.1,2; Gan, Y.3; Zhou, Y.1,2
关键词orthodontics bone remodeling biomechanics inflammation immunity cytokines
刊名JOURNAL OF DENTAL RESEARCH
2015-10-01
DOI10.1177/0022034515595003
94期:10页:1463-1470
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]NECROSIS-FACTOR-ALPHA ; PERIODONTAL-LIGAMENT CELLS ; HUMAN GINGIVAL SULCUS ; IFN-GAMMA ; BONE LOSS ; ROOT RESORPTION ; TNF-ALPHA ; ACTIVATION ; OSTEOCLASTOGENESIS ; EXPRESSION
英文摘要

The immune system plays a pivotal role during bone remodeling process. Orthodontic tooth movement (OTM) induces local inflammation in periodontium, but whether systemic immune response is involved in OTM remains unknown. In this study, we show that tooth movement distance was significantly reduced in T-cell-deficient immunocompromised mice compared with wild-type (WT) mice. Intravenous infusion of allogeneic T cells to the immunocompromised mice rescued the OTM distance. Correspondingly, increased numbers of tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts were detected around the alveolar bone after OTM in WT mice but were barely detected in immunocompromised mice. Moreover, intravenous infusion of T cells rescued the number of TRAP-positive osteoclasts in the OTM area of the immunocompromised mice, thus suggesting T cells are required for OTM. We then reveal that OTM induced a significant elevation of type 1 T helper cell (Th1) cytokines tumor necrosis factor- (TNF-) and interferon- (IFN-) around periodontal tissue in WT but not in immunocompromised mice. Infusion of T cells could increase the levels of TNF- and IFN- in periodontal tissues of immunocompromised mice. More interestingly, intraperitoneal injection of TNF- inhibitor etanercept significantly reduced the distance of OTM in T-cell-infused immunocompromised mice. In summary, this study demonstrates a previously unrecognized mechanism that T cells are required for OTM depending on Th1-associated cytokines.

语种英语
WOS记录号WOS:000361819400019
项目编号2013DFB30360 ; 81470717 ; 81300897
资助机构International S&amp ; T cooperation program of China ; National Natural Science Foundation of China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67454
专题北京大学口腔医学院_牙周科
北京大学基础医学院
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Ctr Craniofacial Stem Cell Res & Regenerat, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Ctr Temporomandibular Disorders & Orofacial Pain, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Yan, Y.,Liu, F.,Kou, X.,et al. T Cells Are Required for Orthodontic Tooth Movement[J]. JOURNAL OF DENTAL RESEARCH,2015,94(10):1463-1470.
APA Yan, Y..,Liu, F..,Kou, X..,Liu, D..,Yang, R..,...&Zhou, Y..(2015).T Cells Are Required for Orthodontic Tooth Movement.JOURNAL OF DENTAL RESEARCH,94(10),1463-1470.
MLA Yan, Y.,et al."T Cells Are Required for Orthodontic Tooth Movement".JOURNAL OF DENTAL RESEARCH 94.10(2015):1463-1470.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yan, Y.]的文章
[Liu, F.]的文章
[Kou, X.]的文章
百度学术
百度学术中相似的文章
[Yan, Y.]的文章
[Liu, F.]的文章
[Kou, X.]的文章
必应学术
必应学术中相似的文章
[Yan, Y.]的文章
[Liu, F.]的文章
[Kou, X.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。