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学科主题口腔医学
Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas
Jen, KY; Cheng, J; Li, J; Wu, LY; Li, YF; Yu, SF; Lin, HL; Chen, ZL; Gurtsevitch, V; Saku, T
关键词EBV LMP1 lymphoepithelial carcinoma mutation salivary gland
刊名INTERNATIONAL JOURNAL OF CANCER
2003-07-10
DOI10.1002/ijc.11100
105期:5页:654-660
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]NF-KAPPA-B ; NASOPHARYNGEAL CARCINOMA ; LATENT MEMBRANE-PROTEIN-1 ; 30-BP DELETION ; HONG-KONG ; VARIANT ; ASSOCIATION ; CHINESE ; TUMORS ; PREVALENCE
英文摘要

It is still unknown what kinds of roles Epstein-Barr virus (EBV) infection that are highly specific to salivary gland lymphoepithelial carcinomas (LECs) play in their tumorigenesis. To clarify the significance of EBV in LECs, we paid particular attention to the LMPI gene, which is responsible for triggering several pathways for activating transcription factors. Sixty-one cases of EBV positive LECs confirmed by PCR and in-situ hybridization were collected from various areas of the world and studied immunohistochemically for latent membrane protein-I. Furthermore, PCR for the LMPI carboxyl (C)-terminus region was performed, and the PCR products were sequenced for detection of other mutational events. LMPI gene products were immunohistochemically demonstrated in 51% of the cases, while PCR amplification of the LMPI gene was successful in 41 cases (67%). Among them, a 30 bp deletion in the C-terminus of the LMPI gene, which had been shown to be characteristic to EBV in Chinese nasopharyngeal carcinomas, was found in 20 cases (32%). Most of them were from Guangzhou, Chengdu and Taiwan, while most of the cases from Shanghai and other areas exhibited no 30 bp deletion. In addition, several point mutations including codon 338 of LMPI were commonly shared by the cases with or without the 30 bp deletion. These results indicate that there are 2 major genomic variations of EBV infecting salivary gland LECs. The frequent mutational events in the C-terminus in addition to the 30 bp deletion also seem to be critical for the pathogenesis because such mutational events may possibly promote cellular proliferation.

语种英语
WOS记录号WOS:000183474000012
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67455
专题北京大学口腔医学院_口腔病理科
作者单位1.NN Blokhin Canc Res Ctr, Viral Carcinogenesis Lab, Moscow, Russia
2.Niigata Univ, Div Oral Pathol, Dept Tissue Regenerat & Reconstruct, Grad Sch Med & Dent Sci, Niigata 9518514, Japan
3.Shanghai Med Univ 2, Dept Oral Pathol, Sch Stomatol, Shanghai, Peoples R China
4.W China Univ Med Sci, Dept Oral Pathol, Sch Stomatol, Chengdu 610041, Peoples R China
5.Kunming Med Coll, Dept Oral Pathol, Fac Stomatol, Kunming, Peoples R China
6.Beijing Univ, Dept Oral Pathol, Sch Stomatol, Beijing 100871, Peoples R China
7.Sun Yat Sen Univ Med Sci, Dept Pathol, Guangzhou, Peoples R China
8.Natl Taiwan Univ, Dept Pathol, Coll Med, Taipei 10764, Taiwan
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Jen, KY,Cheng, J,Li, J,et al. Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas[J]. INTERNATIONAL JOURNAL OF CANCER,2003,105(5):654-660.
APA Jen, KY.,Cheng, J.,Li, J.,Wu, LY.,Li, YF.,...&Saku, T.(2003).Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas.INTERNATIONAL JOURNAL OF CANCER,105(5),654-660.
MLA Jen, KY,et al."Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas".INTERNATIONAL JOURNAL OF CANCER 105.5(2003):654-660.
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