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IR@PKUHSC  > 北京大学口腔医学院  > 口腔病理科  > 期刊论文
学科主题: 口腔医学
题名:
Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas
作者: Jen, KY; Cheng, J; Li, J; Wu, LY; Li, YF; Yu, SF; Lin, HL; Chen, ZL; Gurtsevitch, V; Saku, T
关键词: EBV ; LMP1 ; lymphoepithelial carcinoma ; mutation ; salivary gland
刊名: INTERNATIONAL JOURNAL OF CANCER
发表日期: 2003-07-10
DOI: 10.1002/ijc.11100
卷: 105, 期:5, 页:654-660
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: NF-KAPPA-B ; NASOPHARYNGEAL CARCINOMA ; LATENT MEMBRANE-PROTEIN-1 ; 30-BP DELETION ; HONG-KONG ; VARIANT ; ASSOCIATION ; CHINESE ; TUMORS ; PREVALENCE
英文摘要:

It is still unknown what kinds of roles Epstein-Barr virus (EBV) infection that are highly specific to salivary gland lymphoepithelial carcinomas (LECs) play in their tumorigenesis. To clarify the significance of EBV in LECs, we paid particular attention to the LMPI gene, which is responsible for triggering several pathways for activating transcription factors. Sixty-one cases of EBV positive LECs confirmed by PCR and in-situ hybridization were collected from various areas of the world and studied immunohistochemically for latent membrane protein-I. Furthermore, PCR for the LMPI carboxyl (C)-terminus region was performed, and the PCR products were sequenced for detection of other mutational events. LMPI gene products were immunohistochemically demonstrated in 51% of the cases, while PCR amplification of the LMPI gene was successful in 41 cases (67%). Among them, a 30 bp deletion in the C-terminus of the LMPI gene, which had been shown to be characteristic to EBV in Chinese nasopharyngeal carcinomas, was found in 20 cases (32%). Most of them were from Guangzhou, Chengdu and Taiwan, while most of the cases from Shanghai and other areas exhibited no 30 bp deletion. In addition, several point mutations including codon 338 of LMPI were commonly shared by the cases with or without the 30 bp deletion. These results indicate that there are 2 major genomic variations of EBV infecting salivary gland LECs. The frequent mutational events in the C-terminus in addition to the 30 bp deletion also seem to be critical for the pathogenesis because such mutational events may possibly promote cellular proliferation.

语种: 英语
WOS记录号: WOS:000183474000012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67455
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

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作者单位: 1.NN Blokhin Canc Res Ctr, Viral Carcinogenesis Lab, Moscow, Russia
2.Niigata Univ, Div Oral Pathol, Dept Tissue Regenerat & Reconstruct, Grad Sch Med & Dent Sci, Niigata 9518514, Japan
3.Shanghai Med Univ 2, Dept Oral Pathol, Sch Stomatol, Shanghai, Peoples R China
4.W China Univ Med Sci, Dept Oral Pathol, Sch Stomatol, Chengdu 610041, Peoples R China
5.Kunming Med Coll, Dept Oral Pathol, Fac Stomatol, Kunming, Peoples R China
6.Beijing Univ, Dept Oral Pathol, Sch Stomatol, Beijing 100871, Peoples R China
7.Sun Yat Sen Univ Med Sci, Dept Pathol, Guangzhou, Peoples R China
8.Natl Taiwan Univ, Dept Pathol, Coll Med, Taipei 10764, Taiwan

Recommended Citation:
Jen, KY,Cheng, J,Li, J,et al. Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas[J]. INTERNATIONAL JOURNAL OF CANCER,2003,105(5):654-660.
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