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学科主题: 临床医学
题名:
Molecular characterization of vancomycin-resistant Enterococcus faecium isolates from mainland China
作者: Zheng, Bo; Tomita, Haruyoshi; Xiao, Yong Hong; Wang, Shan; Li, Yun; Ike, Yasuyoshi
刊名: JOURNAL OF CLINICAL MICROBIOLOGY
发表日期: 2007-09-01
DOI: 10.1128/JCM.00457-07
卷: 45, 期:9, 页:2813-2818
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Microbiology
研究领域[WOS]: Microbiology
关键词[WOS]: VANA GLYCOPEPTIDE RESISTANCE ; TN1546-LIKE ELEMENTS ; STREPTOCOCCUS-FAECALIS ; SEX-PHEROMONES ; PLASMID ; HUMANS ; IDENTIFICATION ; DIVERSITY ; JAPAN ; GENE
英文摘要:

Little is known about vancomycin-resistant enterococei in China. Thirteen pulsed-field gel electrophoresis-confirmed heterogeneous VanA-type vancomycin-resistant Enterococcus faecium (VRF) isolates were obtained from five Chinese hospitals from 2.001 to 2005. The isolates were typed by multilocus sequence typing into nine different sequence types (STs), including five new STs (ST18, ST25, ST78, ST203, ST320, ST321, ST322, ST323, and ST335). Vancomycin resistance in each isolate was encoded on conjugative plasmids; two of the plasmids, pZB18 (67 kbp) and pZB22 (200.kbp), were highly conjugative and were able to transfer at high frequencies of around 10(-4) and 10(-7) per donor cell in broth mating, respectively. None of the plasmids identified in these isolates carried traA, which is usually conserved in the pMG1-like highly conjugative plasmid for E. faecium, implying that pZB18 and pZB22 were novel types of a highly conjugative plasmid in enterococci. Thirteen Tn1546-like elements encoding VanA-type VRE on the conjugative plasmids were classified into six types (types I to VI), and most of them contained both IS1216V and IS1542 insertions. The isolates carrying the type 11 element were predominant. The six type elements were different from that of a VanA-type Enterococcus faecalis strain isolated from Chinese chicken meat. The results suggested that the disseminations of VRE in these areas were by Tn1546-like elements being acquired by the conjugative plasmids and transferred among E. faecium strains.

语种: 英语
WOS记录号: WOS:000249506900010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67463
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

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作者单位: 1.Gunma Univ, Grad Sch Med, Dept Bacteriol & Bacterial Infect Control, Gunma 3718511, Japan
2.Peking Univ First Hosp, Inst Clin Pharmacol, Beijing 100034, Peoples R China
3.Gunma Univ, Grad Sch Med, Lab Bacterial Drug Resistance, Gunma 3718511, Japan

Recommended Citation:
Zheng, Bo,Tomita, Haruyoshi,Xiao, Yong Hong,et al. Molecular characterization of vancomycin-resistant Enterococcus faecium isolates from mainland China[J]. JOURNAL OF CLINICAL MICROBIOLOGY,2007,45(9):2813-2818.
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