IR@PKUHSC  > 北京大学药学院
学科主题药学
Rational design and synthesis of potent aminoglycoside antibiotics against resistant bacterial strains
Yan, Ri-Bai1; Yuan, Min2,3; Wu, Yanfen1; You, Xuefu2,3; Ye, Xin-Shan1
关键词Antibiotics Aminoglycoside Drug design Chemical modification Drug resistance
刊名BIOORGANIC & MEDICINAL CHEMISTRY
2011
DOI10.1016/j.bmc.2010.11.065
19期:1页:30-40
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
关键词[WOS]MOLECULAR RECOGNITION ; CRYSTAL-STRUCTURES ; TARGETING RNA ; RIBOSOMAL-RNA ; DERIVATIVES ; NEOMYCIN ; NEAMINE ; ENZYMES ; INHIBITION ; COMPLEXES
英文摘要

Based on the structural information of biomacromolecule-aminoglycoside complexes, a series of kanamycin B analogues were rationally designed and synthesized. A convenient approach to the construction of kanamycin derivatives, in which the C4′-position on ring I of neamine moiety was modified, was developed. Most synthetic analogues exhibited good to excellent antibiotic activity against some typical drug-resistant bacteria. The disclosed results suggested that the C4′-position of aminoglycosides such as kanamycin may be an ideal site for modification to gain new modifying enzyme-resistant aminoglycoside antibiotics. (C) 2010 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000285724800003
项目编号2009ZX09501-011
资助机构National Natural Science Foundation of China ; Ministry of Science and Technology of China
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67467
专题北京大学药学院
北京大学药学院_药物化学系
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Union Med Coll, Inst Med Biotechnol, Beijing 100050, Peoples R China
3.Chinese Acad Med Sci, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714
Yan, Ri-Bai,Yuan, Min,Wu, Yanfen,et al. Rational design and synthesis of potent aminoglycoside antibiotics against resistant bacterial strains[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2011,19(1):30-40.
APA Yan, Ri-Bai,Yuan, Min,Wu, Yanfen,You, Xuefu,&Ye, Xin-Shan.(2011).Rational design and synthesis of potent aminoglycoside antibiotics against resistant bacterial strains.BIOORGANIC & MEDICINAL CHEMISTRY,19(1),30-40.
MLA Yan, Ri-Bai,et al."Rational design and synthesis of potent aminoglycoside antibiotics against resistant bacterial strains".BIOORGANIC & MEDICINAL CHEMISTRY 19.1(2011):30-40.
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