北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 化学生物学系  > 期刊论文
学科主题: 药学
题名:
Gadolinium triggers unfolded protein responses (UPRs) in primary cultured rat cortical astrocytes via promotion of an influx of extracellular Ca2+
作者: Feng, Xu-Dong; Xia, Qing; Yuan, Lan; Huang, Hai-Feng; Yang, Xiao-Da; Wang, Kui
关键词: Gadolinium ; Astrocytes ; Calcium homeostasis ; Endoplasmic reticulum ; Stress
刊名: CELL BIOLOGY AND TOXICOLOGY
发表日期: 2011-02-01
DOI: 10.1007/s10565-010-9166-2
卷: 27, 期:1, 页:1-12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Toxicology
研究领域[WOS]: Cell Biology ; Toxicology
关键词[WOS]: ENDOPLASMIC-RETICULUM STRESS ; INDUCED OXIDATIVE STRESS ; ER STRESS ; MOLECULAR CHAPERONE ; CALCIUM-CHANNELS ; GOLGI-APPARATUS ; NERVOUS-SYSTEM ; CELL-DEATH ; NEURONS ; GRP78
英文摘要:

Gadolinium (Gd) and its complexes are utilized widely in industrial and clinical diagnoses. As a rare earth metal ion, free gadolinium (Gd3+) in the human body poses neurotoxic risks during its in vivo release and retention. In the central nervous system, astrocytes play a pivotal role in processing toxic metal ions. The present study evaluates the effects of Gd on cellular calcium homeostasis, a common mechanism that causes cell death, and on unfolded protein responses (UPRs), a mechanism for cell survival in response to toxic stimuli in mammalian cells. The experimental results indicate that the influx of extracellular Ca2+ increases greatly after the exposure of astrocytes to Gd; however, no cell deaths were observed. Further evidence suggests the up-regulated expression of the endoplasmic reticulum (ER)-resident chaperone protein GRP78 by ER stress-mediated signal transductions, specifically the activation of ATF6, eIF2a, and IRE1. These results suggest that Gd promotes Ca2+ influx, thus triggering UPRs, which can be closely associated to the resistance of astrocytes to Gd-induced cytotoxicity.

语种: 英语
所属项目编号: 20901005 ; 20637010 ; 200800011056
项目资助者: NNSFC ; Research Fund for the Doctoral Program of Higher Education
WOS记录号: WOS:000285876400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67473
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Feng, Xu-Dong,Xia, Qing,Yuan, Lan,et al. Gadolinium triggers unfolded protein responses (UPRs) in primary cultured rat cortical astrocytes via promotion of an influx of extracellular Ca2+[J]. CELL BIOLOGY AND TOXICOLOGY,2011,27(1):1-12.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Feng, Xu-Dong]'s Articles
[Xia, Qing]'s Articles
[Yuan, Lan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Feng, Xu-Dong]‘s Articles
[Xia, Qing]‘s Articles
[Yuan, Lan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace