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学科主题: 药学
题名:
Gadolinium triggers unfolded protein responses (UPRs) in primary cultured rat cortical astrocytes via promotion of an influx of extracellular Ca2+
作者: Feng, Xu-Dong; Xia, Qing; Yuan, Lan; Huang, Hai-Feng; Yang, Xiao-Da; Wang, Kui
关键词: Gadolinium ; Astrocytes ; Calcium homeostasis ; Endoplasmic reticulum ; Stress
刊名: CELL BIOLOGY AND TOXICOLOGY
发表日期: 2011-02-01
DOI: 10.1007/s10565-010-9166-2
卷: 27, 期:1, 页:1-12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Toxicology
研究领域[WOS]: Cell Biology ; Toxicology
关键词[WOS]: ENDOPLASMIC-RETICULUM STRESS ; INDUCED OXIDATIVE STRESS ; ER STRESS ; MOLECULAR CHAPERONE ; CALCIUM-CHANNELS ; GOLGI-APPARATUS ; NERVOUS-SYSTEM ; CELL-DEATH ; NEURONS ; GRP78
英文摘要:

Gadolinium (Gd) and its complexes are utilized widely in industrial and clinical diagnoses. As a rare earth metal ion, free gadolinium (Gd3+) in the human body poses neurotoxic risks during its in vivo release and retention. In the central nervous system, astrocytes play a pivotal role in processing toxic metal ions. The present study evaluates the effects of Gd on cellular calcium homeostasis, a common mechanism that causes cell death, and on unfolded protein responses (UPRs), a mechanism for cell survival in response to toxic stimuli in mammalian cells. The experimental results indicate that the influx of extracellular Ca2+ increases greatly after the exposure of astrocytes to Gd; however, no cell deaths were observed. Further evidence suggests the up-regulated expression of the endoplasmic reticulum (ER)-resident chaperone protein GRP78 by ER stress-mediated signal transductions, specifically the activation of ATF6, eIF2a, and IRE1. These results suggest that Gd promotes Ca2+ influx, thus triggering UPRs, which can be closely associated to the resistance of astrocytes to Gd-induced cytotoxicity.

语种: 英语
所属项目编号: 20901005 ; 20637010 ; 200800011056
项目资助者: NNSFC ; Research Fund for the Doctoral Program of Higher Education
WOS记录号: WOS:000285876400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67473
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Feng, Xu-Dong,Xia, Qing,Yuan, Lan,et al. Gadolinium triggers unfolded protein responses (UPRs) in primary cultured rat cortical astrocytes via promotion of an influx of extracellular Ca2+[J]. CELL BIOLOGY AND TOXICOLOGY,2011,27(1):1-12.
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