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学科主题: 基础医学
题名:
PPAR gamma as a therapeutic target in diabetic nephropathy and other renal diseases
作者: Yang, Jichun; Zhou, Yunfeng; Guan, Youfei
关键词: diabetic nephropathy ; hypertension ; kidney injury ; PPAR
刊名: CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
发表日期: 2012
DOI: 10.1097/MNH.0b013e32834de526
卷: 21, 期:1, 页:97-105
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology ; Peripheral Vascular Disease
研究领域[WOS]: Urology & Nephrology ; Cardiovascular System & Cardiology
关键词[WOS]: ACTIVATED-RECEPTOR-GAMMA ; GLYCATION END-PRODUCTS ; TUBULAR EPITHELIAL-CELLS ; CHRONIC KIDNEY-DISEASE ; NF-KAPPA-B ; INSULIN-RESISTANCE ; MESANGIAL CELLS ; ANGIOTENSIN-II ; BLOOD-PRESSURE ; ADIPONECTIN RECEPTORS
英文摘要:

Purpose of review

Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a ligand-activated nuclear transcription factor that regulates many important physiological processes including glucose and lipid metabolism, energy homeostasis, cell proliferation, inflammation, immunity and reproduction. The current review aims to summarize and discuss recent findings evaluating the protective effects of PPAR gamma against kidney diseases with a focus on diabetic nephropathy. We will also delineate the potential underlying mechanisms.

Recent findings

PPAR gamma plays important roles in renal physiology and pathophysiology. Agonists of PPAR gamma exert protective effects against various kidney diseases including diabetic nephropathy, ischemic renal injury, IgA nephropathy, chemotherapy-associated kidney damage, polycystic kidney diseases and age-related kidney diseases via both systemic and renal actions.

Summary

PPAR gamma agonists are effective in delaying and even preventing the progression of many renal diseases, especially diabetic nephropathy. PPAR gamma may represent a promising target for the treatment of renal diseases.

语种: 英语
所属项目编号: 30890041/8103003/30725033/30870995 ; 2010CB912503 ; 2012CB517504
项目资助者: Natural Science Foundation ; Ministry of Science and Technology
WOS记录号: WOS:000298144300015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67476
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: Peking Beijing Univ Hlth Sci Ctr, Dept Physiol & Pathophysiol, Peking Beijing Univ Diabet Ctr, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Jichun,Zhou, Yunfeng,Guan, Youfei. PPAR gamma as a therapeutic target in diabetic nephropathy and other renal diseases[J]. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION,2012,21(1):97-105.
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