IR@PKUHSC  > 北京大学基础医学院  > 心血管所
学科主题基础医学
PPAR gamma as a therapeutic target in diabetic nephropathy and other renal diseases
Yang, Jichun; Zhou, Yunfeng; Guan, Youfei
关键词diabetic nephropathy hypertension kidney injury PPAR
刊名CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
2012
DOI10.1097/MNH.0b013e32834de526
21期:1页:97-105
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology ; Peripheral Vascular Disease
研究领域[WOS]Urology & Nephrology ; Cardiovascular System & Cardiology
关键词[WOS]ACTIVATED-RECEPTOR-GAMMA ; GLYCATION END-PRODUCTS ; TUBULAR EPITHELIAL-CELLS ; CHRONIC KIDNEY-DISEASE ; NF-KAPPA-B ; INSULIN-RESISTANCE ; MESANGIAL CELLS ; ANGIOTENSIN-II ; BLOOD-PRESSURE ; ADIPONECTIN RECEPTORS
英文摘要

Purpose of review

Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a ligand-activated nuclear transcription factor that regulates many important physiological processes including glucose and lipid metabolism, energy homeostasis, cell proliferation, inflammation, immunity and reproduction. The current review aims to summarize and discuss recent findings evaluating the protective effects of PPAR gamma against kidney diseases with a focus on diabetic nephropathy. We will also delineate the potential underlying mechanisms.

Recent findings

PPAR gamma plays important roles in renal physiology and pathophysiology. Agonists of PPAR gamma exert protective effects against various kidney diseases including diabetic nephropathy, ischemic renal injury, IgA nephropathy, chemotherapy-associated kidney damage, polycystic kidney diseases and age-related kidney diseases via both systemic and renal actions.

Summary

PPAR gamma agonists are effective in delaying and even preventing the progression of many renal diseases, especially diabetic nephropathy. PPAR gamma may represent a promising target for the treatment of renal diseases.

语种英语
WOS记录号WOS:000298144300015
项目编号30890041/8103003/30725033/30870995 ; 2010CB912503 ; 2012CB517504
资助机构Natural Science Foundation ; Ministry of Science and Technology
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67476
专题北京大学基础医学院_心血管所
作者单位Peking Beijing Univ Hlth Sci Ctr, Dept Physiol & Pathophysiol, Peking Beijing Univ Diabet Ctr, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
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GB/T 7714
Yang, Jichun,Zhou, Yunfeng,Guan, Youfei. PPAR gamma as a therapeutic target in diabetic nephropathy and other renal diseases[J]. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION,2012,21(1):97-105.
APA Yang, Jichun,Zhou, Yunfeng,&Guan, Youfei.(2012).PPAR gamma as a therapeutic target in diabetic nephropathy and other renal diseases.CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION,21(1),97-105.
MLA Yang, Jichun,et al."PPAR gamma as a therapeutic target in diabetic nephropathy and other renal diseases".CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION 21.1(2012):97-105.
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