| 学科主题 | 基础医学 |
| PPAR gamma as a therapeutic target in diabetic nephropathy and other renal diseases | |
| Yang, Jichun; Zhou, Yunfeng; Guan, Youfei | |
| 关键词 | diabetic nephropathy hypertension kidney injury PPAR |
| 刊名 | CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
 |
| 2012 | |
| DOI | 10.1097/MNH.0b013e32834de526 |
| 卷 | 21期:1页:97-105 |
| 收录类别 | SCI |
| 文章类型 | Review |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Urology & Nephrology ; Peripheral Vascular Disease |
| 资助者 | Natural Science Foundation ; Ministry of Science and Technology ; Natural Science Foundation ; Ministry of Science and Technology |
| 研究领域[WOS] | Urology & Nephrology ; Cardiovascular System & Cardiology |
| 关键词[WOS] | ACTIVATED-RECEPTOR-GAMMA ; GLYCATION END-PRODUCTS ; TUBULAR EPITHELIAL-CELLS ; CHRONIC KIDNEY-DISEASE ; NF-KAPPA-B ; INSULIN-RESISTANCE ; MESANGIAL CELLS ; ANGIOTENSIN-II ; BLOOD-PRESSURE ; ADIPONECTIN RECEPTORS |
| 英文摘要 | Purpose of review Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a ligand-activated nuclear transcription factor that regulates many important physiological processes including glucose and lipid metabolism, energy homeostasis, cell proliferation, inflammation, immunity and reproduction. The current review aims to summarize and discuss recent findings evaluating the protective effects of PPAR gamma against kidney diseases with a focus on diabetic nephropathy. We will also delineate the potential underlying mechanisms. Recent findings PPAR gamma plays important roles in renal physiology and pathophysiology. Agonists of PPAR gamma exert protective effects against various kidney diseases including diabetic nephropathy, ischemic renal injury, IgA nephropathy, chemotherapy-associated kidney damage, polycystic kidney diseases and age-related kidney diseases via both systemic and renal actions. Summary PPAR gamma agonists are effective in delaying and even preventing the progression of many renal diseases, especially diabetic nephropathy. PPAR gamma may represent a promising target for the treatment of renal diseases. |
| 语种 | 英语 |
| 所属项目编号 | 30890041/8103003/30725033/30870995 ; 2010CB912503 ; 2012CB517504 |
| 资助者 | Natural Science Foundation ; Ministry of Science and Technology ; Natural Science Foundation ; Ministry of Science and Technology |
| WOS记录号 | WOS:000298144300015 |
| Citation statistics | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/67476 |
| Collection | 北京大学基础医学院_心血管所 |
| 作者单位 | Peking Beijing Univ Hlth Sci Ctr, Dept Physiol & Pathophysiol, Peking Beijing Univ Diabet Ctr, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China |
| Recommended Citation GB/T 7714 | Yang, Jichun,Zhou, Yunfeng,Guan, Youfei. PPAR gamma as a therapeutic target in diabetic nephropathy and other renal diseases[J]. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION,2012,21(1):97-105. |
| APA | Yang, Jichun,Zhou, Yunfeng,&Guan, Youfei.(2012).PPAR gamma as a therapeutic target in diabetic nephropathy and other renal diseases.CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION,21(1),97-105. |
| MLA | Yang, Jichun,et al."PPAR gamma as a therapeutic target in diabetic nephropathy and other renal diseases".CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION 21.1(2012):97-105. |
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