PPAR gamma as a therapeutic target in diabetic nephropathy and other renal diseases

doi:10.1097/MNH.0b013e32834de526

IR@PKUHSC > 北京大学基础医学院 > 心血管所

学科主题	基础医学
	PPAR gamma as a therapeutic target in diabetic nephropathy and other renal diseases
	Yang, Jichun; Zhou, Yunfeng; Guan, Youfei
关键词	diabetic nephropathy hypertension kidney injury PPAR
刊名	CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
	2012
DOI	10.1097/MNH.0b013e32834de526
卷	21 期:1 页:97-105
收录类别	SCI
文章类型	Review
WOS标题词	Science & Technology
类目[WOS]	Urology & Nephrology ; Peripheral Vascular Disease
研究领域[WOS]	Urology & Nephrology ; Cardiovascular System & Cardiology
关键词[WOS]	ACTIVATED-RECEPTOR-GAMMA ; GLYCATION END-PRODUCTS ; TUBULAR EPITHELIAL-CELLS ; CHRONIC KIDNEY-DISEASE ; NF-KAPPA-B ; INSULIN-RESISTANCE ; MESANGIAL CELLS ; ANGIOTENSIN-II ; BLOOD-PRESSURE ; ADIPONECTIN RECEPTORS
英文摘要	Purpose of review Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a ligand-activated nuclear transcription factor that regulates many important physiological processes including glucose and lipid metabolism, energy homeostasis, cell proliferation, inflammation, immunity and reproduction. The current review aims to summarize and discuss recent findings evaluating the protective effects of PPAR gamma against kidney diseases with a focus on diabetic nephropathy. We will also delineate the potential underlying mechanisms. Recent findings PPAR gamma plays important roles in renal physiology and pathophysiology. Agonists of PPAR gamma exert protective effects against various kidney diseases including diabetic nephropathy, ischemic renal injury, IgA nephropathy, chemotherapy-associated kidney damage, polycystic kidney diseases and age-related kidney diseases via both systemic and renal actions. Summary PPAR gamma agonists are effective in delaying and even preventing the progression of many renal diseases, especially diabetic nephropathy. PPAR gamma may represent a promising target for the treatment of renal diseases.
语种	英语
WOS记录号	WOS:000298144300015
项目编号	30890041/8103003/30725033/30870995 ; 2010CB912503 ; 2012CB517504
资助机构	Natural Science Foundation ; Ministry of Science and Technology
引用统计	被引频次：25[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.bjmu.edu.cn/handle/400002259/67476
专题	北京大学基础医学院_心血管所北京大学基础医学院
作者单位	Peking Beijing Univ Hlth Sci Ctr, Dept Physiol & Pathophysiol, Peking Beijing Univ Diabet Ctr, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	Yang, Jichun,Zhou, Yunfeng,Guan, Youfei. PPAR gamma as a therapeutic target in diabetic nephropathy and other renal diseases[J]. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION,2012,21(1):97-105.
APA	Yang, Jichun,Zhou, Yunfeng,&Guan, Youfei.(2012).PPAR gamma as a therapeutic target in diabetic nephropathy and other renal diseases.CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION,21(1),97-105.
MLA	Yang, Jichun,et al."PPAR gamma as a therapeutic target in diabetic nephropathy and other renal diseases".CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION 21.1(2012):97-105.