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学科主题临床医学
Expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics
Ma, Ding1; Cheng, Yuan1; Zhang, Youyi2,3; Guo, Yanli1; Li, Zijian2,3; Li, Geng1
关键词Cell division cycle 42 protein (CDC42) cervical squamous cell carcinoma expression
刊名CHINESE JOURNAL OF CANCER RESEARCH
2013-12-01
DOI10.3978/j.issn.1000-9604.2013.11.04
25期:6页:656-661
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program)
研究领域[WOS]Oncology
关键词[WOS]RHO-GTPASES ; CANCER ; RAC1 ; TRANSFORMATION ; INVASION ; PROGRESSION ; METASTASIS ; PATHWAY ; TUMORS
英文摘要

Objective: The high expression of cell division cycle 42 protein (CDC42) may be involved in the occurrence and progression of several tumors. However, the expression and function of CDC42 in cervical squamous cell carcinoma remains unclear. This study aimed to investigate the expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics.

Methods: The expression of CDC42 in 162 cervical squamous cell carcinoma tissue samples and 33 normal cervical tissue samples was investigated by immunohistochemistry. The CDC42 mRNA expression was detected by reverse transcription-polymerase chain reaction (RT-PCR).

Results: The cervical squamous cell carcinoma group showed a significantly higher CDC42 positive rate, compared to the normal cervical tissues (P<0.05). Furthermore, the tissues of stage II-IV carcinoma patients showed higher CDC42 expression levels compared to stage I patients (P=0.05). In addition, the expression of CDC42 was not correlated to age of patients, differentiation degree of cancer cells, or lymph node metastasis (P>0.05). Furthermore, compare with normal cervical tissues, the CDC42 mRNA expression in cervical cancer had no significant difference.

Conclusions: CDC42 was up-regulated at protein level, but not mRNA level, in cervical squamous cell carcinoma. The high expression of CDC42 was correlated to the clinical stage of the patients, indicating that CDC42 might contribute to the progression of cervical squamous cell carcinoma.

语种英语
所属项目编号11072006 ; 10772007 ; 81070078 ; 2013CB933702
资助者National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program)
WOS记录号WOS:000329477800005
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67478
专题北京大学第三临床医学院
作者单位1.Peking Univ, Hosp 3, Dept Gynecol & Obstet, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100191, Peoples R China
3.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptide, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Ma, Ding,Cheng, Yuan,Zhang, Youyi,et al. Expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics[J]. CHINESE JOURNAL OF CANCER RESEARCH,2013,25(6):656-661.
APA Ma, Ding,Cheng, Yuan,Zhang, Youyi,Guo, Yanli,Li, Zijian,&Li, Geng.(2013).Expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics.CHINESE JOURNAL OF CANCER RESEARCH,25(6),656-661.
MLA Ma, Ding,et al."Expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics".CHINESE JOURNAL OF CANCER RESEARCH 25.6(2013):656-661.
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