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L-Asparaginase in the treatment of refractory and relapsed extranodal NK/T-cell lymphoma, nasal type
Yong, Weiben1; Zheng, Wen1; Zhu, Jun1; Zhang, Yuntao1; Wang, Xiaopei1; Xie, Yan1; Lin, Ningjing1; Xu, Bo2; Lu, Aiping3; Li, Jiyou3
关键词Extranodal NK/T-cell lymphoma L-Asparaginase Radiotherapy Chemotherapy Prognostic factor
刊名ANNALS OF HEMATOLOGY
2009-07-01
DOI10.1007/s00277-008-0669-3
88期:7页:647-652
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]NATURAL KILLER/T-CELL ; T-CELL ; PROGNOSTIC-FACTORS ; EXPRESSION ; DIAGNOSIS ; FEATURES ; REGIMEN
英文摘要

There is no standard salvage regimen for patients with refractory and relapsed extranodal NK/T-cell lymphoma (NKTCL), nasal type. This study was conduced to evaluate the efficacy of L-asparaginase-based regimen as a salvage regimen, on refractory and relapsed extranodal NKTCL, nasal type. Between March 1996 and March 2008, 45 patients with refractory and relapsed extranodal NKTCL, nasal type, were studied retrospectively. All patients were treated with L-asparaginase-based salvage regimen. Thirty-nine patients also received primary involved-field radiation after L-asparaginase-based chemotherapy. The complete response rate, partial response rate, and overall response rate for the whole group were 55.6%, 26.7%, and 82.2%, respectively. Both of 3-year and 5-year overall survival (OS) rates were 66.9%. The major adverse effects of L-asparaginase were myelosuppression, liver dysfunction, hyperglycemia, and allergic reaction. In general, the side effects could be tolerated. On univariate analysis, age, the stage of disease, and performance status were found to be prognostic factors influencing OS. On multivariate analysis, the stage of disease and age were independent prognostic factors for OS. L-Asparaginase-based regimen was obviously effective for the patients with refractory and relapsed extranodal NKTCL, nasal type.

语种英语
WOS记录号WOS:000266260300007
项目编号211
资助机构Peking University
引用统计
被引频次:77[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67483
专题北京大学临床肿瘤学院_肿瘤内科
北京大学临床肿瘤学院_淋巴肿瘤内科
北京大学临床肿瘤学院_肿瘤放疗科
北京大学临床肿瘤学院_病理科
北京大学临床肿瘤学院_门诊部
作者单位1.Peking Univ, Dept Med Oncol, Beijing Canc Hosp & Inst, Sch Oncol, Beijing 100036, Peoples R China
2.Peking Univ, Dept Radiat Oncol, Beijing Canc Hosp & Inst, Sch Oncol, Beijing 100036, Peoples R China
3.Peking Univ, Dept Pathol, Beijing Canc Hosp & Inst, Sch Oncol, Beijing 100036, Peoples R China
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GB/T 7714
Yong, Weiben,Zheng, Wen,Zhu, Jun,et al. L-Asparaginase in the treatment of refractory and relapsed extranodal NK/T-cell lymphoma, nasal type[J]. ANNALS OF HEMATOLOGY,2009,88(7):647-652.
APA Yong, Weiben.,Zheng, Wen.,Zhu, Jun.,Zhang, Yuntao.,Wang, Xiaopei.,...&Li, Jiyou.(2009).L-Asparaginase in the treatment of refractory and relapsed extranodal NK/T-cell lymphoma, nasal type.ANNALS OF HEMATOLOGY,88(7),647-652.
MLA Yong, Weiben,et al."L-Asparaginase in the treatment of refractory and relapsed extranodal NK/T-cell lymphoma, nasal type".ANNALS OF HEMATOLOGY 88.7(2009):647-652.
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