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学科主题: 临床医学
题名:
L-Asparaginase in the treatment of refractory and relapsed extranodal NK/T-cell lymphoma, nasal type
作者: Yong, Weiben1; Zheng, Wen1; Zhu, Jun1; Zhang, Yuntao1; Wang, Xiaopei1; Xie, Yan1; Lin, Ningjing1; Xu, Bo2; Lu, Aiping3; Li, Jiyou3
关键词: Extranodal NK/T-cell lymphoma ; L-Asparaginase ; Radiotherapy ; Chemotherapy ; Prognostic factor
刊名: ANNALS OF HEMATOLOGY
发表日期: 2009-07-01
DOI: 10.1007/s00277-008-0669-3
卷: 88, 期:7, 页:647-652
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: NATURAL KILLER/T-CELL ; T-CELL ; PROGNOSTIC-FACTORS ; EXPRESSION ; DIAGNOSIS ; FEATURES ; REGIMEN
英文摘要:

There is no standard salvage regimen for patients with refractory and relapsed extranodal NK/T-cell lymphoma (NKTCL), nasal type. This study was conduced to evaluate the efficacy of L-asparaginase-based regimen as a salvage regimen, on refractory and relapsed extranodal NKTCL, nasal type. Between March 1996 and March 2008, 45 patients with refractory and relapsed extranodal NKTCL, nasal type, were studied retrospectively. All patients were treated with L-asparaginase-based salvage regimen. Thirty-nine patients also received primary involved-field radiation after L-asparaginase-based chemotherapy. The complete response rate, partial response rate, and overall response rate for the whole group were 55.6%, 26.7%, and 82.2%, respectively. Both of 3-year and 5-year overall survival (OS) rates were 66.9%. The major adverse effects of L-asparaginase were myelosuppression, liver dysfunction, hyperglycemia, and allergic reaction. In general, the side effects could be tolerated. On univariate analysis, age, the stage of disease, and performance status were found to be prognostic factors influencing OS. On multivariate analysis, the stage of disease and age were independent prognostic factors for OS. L-Asparaginase-based regimen was obviously effective for the patients with refractory and relapsed extranodal NKTCL, nasal type.

语种: 英语
所属项目编号: 211
项目资助者: Peking University
WOS记录号: WOS:000266260300007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67483
Appears in Collections:北京大学临床肿瘤学院_肿瘤内科_期刊论文

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作者单位: 1.Peking Univ, Dept Med Oncol, Beijing Canc Hosp & Inst, Sch Oncol, Beijing 100036, Peoples R China
2.Peking Univ, Dept Radiat Oncol, Beijing Canc Hosp & Inst, Sch Oncol, Beijing 100036, Peoples R China
3.Peking Univ, Dept Pathol, Beijing Canc Hosp & Inst, Sch Oncol, Beijing 100036, Peoples R China

Recommended Citation:
Yong, Weiben,Zheng, Wen,Zhu, Jun,et al. L-Asparaginase in the treatment of refractory and relapsed extranodal NK/T-cell lymphoma, nasal type[J]. ANNALS OF HEMATOLOGY,2009,88(7):647-652.
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