IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Clinical Features of Pneumonia Caused by 2009 Influenza A(H1N1) Virus in Beijing, China
Bai, Lu2; Gu, Li2; Cao, Bin2,5; Zhai, Xiao-Li3; Lu, Min4; Lu, Yong1; Liang, Li-Rong1; Zhang, Lei3; Gao, Zi-Fen4; Huang, Ke-Wu1; Liu, Ying-Mei2; Song, Shu-Fan2; Wu, Lin2; Yin, Yu-Dong2; Wang, Chen1,5
刊名CHEST
2011-05-01
DOI10.1378/chest.10-1036
139期:5页:1156-1164
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Critical Care Medicine ; Respiratory System
研究领域[WOS]General & Internal Medicine ; Respiratory System
关键词[WOS]ACUTE RESPIRATORY SYNDROME ; CRITICALLY-ILL PATIENTS ; PULMONARY-FUNCTION ; A H1N1 ; EXERCISE CAPACITY ; ADULT PATIENTS ; UNITED-STATES ; LUNG-CHANGES ; INFECTION ; AUSTRALIA
英文摘要

Background: Data on symptoms and radiographic changes in patients with pandemic 2009 influenza A(H1N1) (A[H1N1]) pneumonia during convalescence have not been reported.

Methods During October 26, 2009, and January 23, 2010, adult patients with pneumonia with laboratory-confirmed or clinically suspected A(H1N1) infections were observed for clinical characteristics, high-resolution chest CT scan, and lung function test changes during acute and 3-month convalescent phases.

Results: Of the 65 case subjects, the median age was 41 (interquartile range [IQR], 28-57) years, 60.0% were men, and 55.4% had at least one underlying medical condition. Sixty-two patients started oseltamivir therapy within a median of 5 (IQR, 4-6) days from the onset of illness, and 31 received IV corticosteroids. ARDS developed in 33 patients, and 24 were treated initially with noninvasive positive pressure ventilation (NPPV). In this group, NPPV was successful in 13 patients (54.2%). Nine patients died at a median of 16 (IQR, 10-24) days after onset of illness. Multivariate Cox regression identified two independent risk factors for death: progressive dyspnea after resolution of fever (relative risk, 5.852; 95% CI, 1.395-24.541; P = .016) and a higher APACHE (Acute Physiology and Chronic Health Evaluation) II score on presentation (relative risk for each point, 1.312; 95% CI, 1.140-1.511; P <.001). At 3-month follow-up of survivors with A(H1N1), ground-glass opacities were still present, although diminished, in 85.7%, and diffusing capacity for carbon monoxide was mildly reduced in 61.5%.

Conclusions: Ground-glass opacities and decreased diffusing capacity were the main abnormalities observed at 3-month follow-up of survivors of A(H1N1). CHEST 2011; 139(5):1156-1164

语种英语
WOS记录号WOS:000290554300025
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67484
专题北京大学基础医学院_病理学系
作者单位1.Beijing Key Lab Resp & Pulm Circulat, Beijing, Peoples R China
2.Capital Med Univ, Beijing Inst Resp Med, Beijing Chao Yang Hosp, Dept Resp & Intens Care Med, Beijing 100020, Peoples R China
3.Capital Med Univ, Beijing Chao Yang Hosp, Dept Infect Dis & Clin Microbiol, Beijing 100020, Peoples R China
4.Capital Med Univ, Beijing Chao Yang Hosp, Dept Radiol, Beijing 100020, Peoples R China
5.Peking Univ, Dept Pathol, Sch Basic Med Sci, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Bai, Lu,Gu, Li,Cao, Bin,et al. Clinical Features of Pneumonia Caused by 2009 Influenza A(H1N1) Virus in Beijing, China[J]. CHEST,2011,139(5):1156-1164.
APA Bai, Lu.,Gu, Li.,Cao, Bin.,Zhai, Xiao-Li.,Lu, Min.,...&Wang, Chen.(2011).Clinical Features of Pneumonia Caused by 2009 Influenza A(H1N1) Virus in Beijing, China.CHEST,139(5),1156-1164.
MLA Bai, Lu,et al."Clinical Features of Pneumonia Caused by 2009 Influenza A(H1N1) Virus in Beijing, China".CHEST 139.5(2011):1156-1164.
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