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学科主题: 药学
题名:
Self-assembled nanoparticles based on galactosylated O-carboxymethyl chitosan-graft-stearic acid conjugates for delivery of doxorubicin
作者: Guo, Hejian1; Zhang, Dianrui1; Li, Caiyun1; Jia, Lejiao1; Liu, Guangpu1; Hao, Leilei1; Zheng, Dandan1; Shen, Jingyi1; Li, Tingting1; Guo, Yuanyuan1; Zhang, Qiang2
关键词: O-carboxymethyl chitosan ; Stearic acid ; Liver targeting ; Doxorubicin
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2013-12-15
DOI: 10.1016/j.ijpharm.2013.10.020
卷: 458, 期:1, 页:31-38
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: HEPATOCYTE-TARGETED DELIVERY ; DRUG-DELIVERY ; POLYMERIC MICELLES ; IN-VITRO ; ANTITUMOR-ACTIVITY ; CARRIER ; PACLITAXEL ; DERIVATIVES ; ORIDONIN ; RELEASE
英文摘要:

A novel polymer, i.e. galactosylated O-carboxymethyl chitosan-graft-stearic acid (Gal-OCMC-g-SA) was synthesized for liver targeting delivery of doxorubicin. The chemical structure was characterized by FT-IR, H-1 NMR and elemental analysis. Gal-OCMC-g-SA could self-assemble into nanoparticles with diameter of 160 nm by probe sonication in aqueous medium and exhibited a low critical aggregation concentration of 0.047 mg/mL. The DOX-loaded Gal-OCMC-g-SA (Gal-OCMC-g-SA/DOX) self-assembled nanoparticles were almost spherical in shape with an average diameter of less than 200 nm and zeta potential of around -10 mV. In vitro release revealed that the Gal-OCMC-g-SA/DOX nanoparticles exhibited a sustained and pH-dependent drug release manner. Furthermore, the hemolysis test demonstrated the good safety of Gal-OCMC-g-SA in blood-contacting applications. These results indicated that Gal-OCMC-g-SA/DOX nanoparticles were highly potential to be applied in cancer therapy. (C) 2013 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2009CB930300
项目资助者: National Basic Research Program of China (973 Program)
WOS记录号: WOS:000326983000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67488
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Jinan 250012, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Guo, Hejian,Zhang, Dianrui,Li, Caiyun,et al. Self-assembled nanoparticles based on galactosylated O-carboxymethyl chitosan-graft-stearic acid conjugates for delivery of doxorubicin[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2013,458(1):31-38.
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