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Self-assembled nanoparticles based on galactosylated O-carboxymethyl chitosan-graft-stearic acid conjugates for delivery of doxorubicin
Guo, Hejian1; Zhang, Dianrui1; Li, Caiyun1; Jia, Lejiao1; Liu, Guangpu1; Hao, Leilei1; Zheng, Dandan1; Shen, Jingyi1; Li, Tingting1; Guo, Yuanyuan1; Zhang, Qiang2
关键词O-carboxymethyl chitosan Stearic acid Liver targeting Doxorubicin
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
2013-12-15
DOI10.1016/j.ijpharm.2013.10.020
458期:1页:31-38
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]HEPATOCYTE-TARGETED DELIVERY ; DRUG-DELIVERY ; POLYMERIC MICELLES ; IN-VITRO ; ANTITUMOR-ACTIVITY ; CARRIER ; PACLITAXEL ; DERIVATIVES ; ORIDONIN ; RELEASE
英文摘要

A novel polymer, i.e. galactosylated O-carboxymethyl chitosan-graft-stearic acid (Gal-OCMC-g-SA) was synthesized for liver targeting delivery of doxorubicin. The chemical structure was characterized by FT-IR, H-1 NMR and elemental analysis. Gal-OCMC-g-SA could self-assemble into nanoparticles with diameter of 160 nm by probe sonication in aqueous medium and exhibited a low critical aggregation concentration of 0.047 mg/mL. The DOX-loaded Gal-OCMC-g-SA (Gal-OCMC-g-SA/DOX) self-assembled nanoparticles were almost spherical in shape with an average diameter of less than 200 nm and zeta potential of around -10 mV. In vitro release revealed that the Gal-OCMC-g-SA/DOX nanoparticles exhibited a sustained and pH-dependent drug release manner. Furthermore, the hemolysis test demonstrated the good safety of Gal-OCMC-g-SA in blood-contacting applications. These results indicated that Gal-OCMC-g-SA/DOX nanoparticles were highly potential to be applied in cancer therapy. (C) 2013 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000326983000005
项目编号2009CB930300
资助机构National Basic Research Program of China (973 Program)
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67488
专题北京大学药学院
作者单位1.Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Jinan 250012, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
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Guo, Hejian,Zhang, Dianrui,Li, Caiyun,et al. Self-assembled nanoparticles based on galactosylated O-carboxymethyl chitosan-graft-stearic acid conjugates for delivery of doxorubicin[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2013,458(1):31-38.
APA Guo, Hejian.,Zhang, Dianrui.,Li, Caiyun.,Jia, Lejiao.,Liu, Guangpu.,...&Zhang, Qiang.(2013).Self-assembled nanoparticles based on galactosylated O-carboxymethyl chitosan-graft-stearic acid conjugates for delivery of doxorubicin.INTERNATIONAL JOURNAL OF PHARMACEUTICS,458(1),31-38.
MLA Guo, Hejian,et al."Self-assembled nanoparticles based on galactosylated O-carboxymethyl chitosan-graft-stearic acid conjugates for delivery of doxorubicin".INTERNATIONAL JOURNAL OF PHARMACEUTICS 458.1(2013):31-38.
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