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学科主题: 药物依赖
题名:
Effects of acute combined serotonin and dopamine depletion on cue-induced drinking intention/desire and cognitive function in patients with alcohol dependence
作者: Sun, Hong-Qiang1,2; Liu, Yu3; Li, Peng1; Bao, Yan-Ping1; Sheng, Li-Xia4; Zhang, Rui-Ling5; Cao, Yan-Jun2; Di, Xiao-Lan2; Yang, Fu-De2; Wang, Fan2; Luo, Yi-Xiao1; Lu, Lin1
关键词: Alcohol dependence ; Combined monoamine depletion ; Drinking urge ; Cue exposure
刊名: DRUG AND ALCOHOL DEPENDENCE
发表日期: 2012-08-01
DOI: 10.1016/j.drugalcdep.2012.01.006
卷: 124, 期:3, 页:200-206
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Substance Abuse ; Psychiatry
研究领域[WOS]: Substance Abuse ; Psychiatry
关键词[WOS]: NICOTINIC ACETYLCHOLINE-RECEPTOR ; PARTIAL AGONIST VARENICLINE ; PREFERRING P RATS ; TRYPTOPHAN DEPLETION ; PREFRONTAL CORTEX ; SEEKING BEHAVIOR ; IN-VITRO ; CONSUMPTION ; EXPOSURE ; RELAPSE
英文摘要:

Background: Alcohol cues can precipitate the desire to drink and cause relapse in recovering alcohol-dependent patients. Serotonin and dopamine may play a role in alcohol cue-induced craving. Acute combined tryptophan (Trp), tyrosine (Tyr), and phenylalanine (Phe) depletion (CMD) in the diet attenuates the synthesis of serotonin and dopamine in the human brain. However, no study of the effects of acute CMD has been previously conducted. Therefore, we investigated whether the attenuation of serotonin and dopamine synthesis changes cue-induced alcohol craving in recently abstinent alcoholics.

Methods: In this double-blind, randomized, placebo-controlled, crossover design, 12 male patients who met the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, criteria for alcohol dependence were divided into two conditions: (1) monoamine depletion (i.e., consumption of a concentrated amino acid beverage that resulted in a rapid and significant decrease in plasma-free Tyr/Phe/Trp) and (2) balanced condition (i.e., consumption of a similar beverage that contained Tyr/Phe/Trp). The participants were scheduled for two experimental sessions, with an interval of >= 7 days. The cue-induced craving test session was conducted 6 h after each amino acid beverage administration. Drinking urge, blood pressure, heart rate, working memory, and attention/psychomotor performance were assessed before and after administration.

Results: Compared with the balanced condition, the monoamine depletion condition significantly increased drinking intention/desire and diastolic blood pressure. Cognitive performance was not different between the two conditions.

Conclusions: Acute combined serotonin and dopamine depletion may increase drinking intention/desire and diastolic blood pressure without influencing cognitive function. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 81071080 ; 2010D003034000026
项目资助者: National Natural Science Foundation of China ; Training Program Foundation for Excellent Talents ; Beijing Municipal Government, China
WOS记录号: WOS:000307324400004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67495
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Ningbo Univ, Sch Med, Ningbo 315211, Zhejiang, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
3.Peking Univ, Beijing Hui Long Guan Hosp, Dept Alcohol & Drug Dependence, Beijing 100096, Peoples R China
4.Capital Univ Med Sci, Beijing Anding Hosp, Natl Drug Treatment Ctr, Beijing 100088, Peoples R China
5.Xinxiang Med Univ, Hosp 2, Xinxiang 453002, Henan Province, Peoples R China

Recommended Citation:
Sun, Hong-Qiang,Liu, Yu,Li, Peng,et al. Effects of acute combined serotonin and dopamine depletion on cue-induced drinking intention/desire and cognitive function in patients with alcohol dependence[J]. DRUG AND ALCOHOL DEPENDENCE,2012,124(3):200-206.
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