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The relationship between traffic-related air pollutants and cardiac autonomic function in a panel of healthy adults: a further analysis with existing data
Wu, Shaowei1; Deng, Furong1; Niu, Jie2; Huang, Qinsheng2; Liu, Youcheng3; Guo, Xinbiao1
关键词Air pollution carbon monoxide cardiac autonomic function heart rate variability panel study particulate matter
刊名INHALATION TOXICOLOGY
2011-04-01
DOI10.3109/08958378.2011.568976
23期:5页:289-303
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]HEART-RATE-VARIABILITY ; PARTICULATE MATTER ; METABOLIC SYNDROME ; CARBON-MONOXIDE ; POLLUTION ; EXPOSURE ; DISEASE ; ASSOCIATION ; MICE
英文摘要

Context: Epidemiological studies have linked particulate matter (PM) and carbon monoxide (CO) exposures with alterations in cardiac autonomic function as measured by heart rate variability (HRV) in populations. Recently, we reported association of several HRV indices with marked changes in particulate air pollution around the Beijing 2008 Olympic Games in a panel of healthy adults.

Objective: We further investigated the cardiac effects of traffic-related air pollutants over wide exposure ranges with expanded data set in this panel of healthy adults.

Methods: We obtained real-time data on nine taxi drivers′ in-car exposures to PM <= 2.5 mu m in aerodynamic diameter (PM 2.5) and CO and on multiple HRV indices during a separate daily work shift in four study periods with dramatically changing air pollution levels around the Beijing 2008 Olympic Games. Mixed effect models and a loess smoother method were used to investigate the associations of exposures with HRV indices.

Results: Results showed overall negative associations of traffic-related air pollutants with HRV indices across periods, as well as differences in period-specific and individual associations. After stratifying the individuals into two different response groups (positive/negative), cardiac effects of air pollutants became stronger within each group. Exposure-response modeling identified changed curvilinear relationships between air pollution exposures and HRV indices with threshold effects.

Discussion and conclusion: Our results support the association of exposure to traffic-related air pollution with altered cardiac autonomic function in young healthy adults free of cardiovascular compromises. These results suggest a complicated mechanism that traffic-related air pollutants influence the cardiovascular system of healthy adults.

语种英语
WOS记录号WOS:000289797700005
项目编号2006BAI19B06 ; 81072267
资助机构National Key Technologies R&amp ; D Program of China ; National Natural Science Foundation of China
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67498
专题北京大学公共卫生学院
北京大学公共卫生学院_劳动卫生与环境卫生学系
北京大学公共卫生学院_公共卫生学院
北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
3.Univ N Texas, Hlth Sci Ctr, Sch Publ Hlth, Dept Environm & Occupat Hlth Sci, Ft Worth, TX USA
推荐引用方式
GB/T 7714
Wu, Shaowei,Deng, Furong,Niu, Jie,et al. The relationship between traffic-related air pollutants and cardiac autonomic function in a panel of healthy adults: a further analysis with existing data[J]. INHALATION TOXICOLOGY,2011,23(5):289-303.
APA Wu, Shaowei,Deng, Furong,Niu, Jie,Huang, Qinsheng,Liu, Youcheng,&Guo, Xinbiao.(2011).The relationship between traffic-related air pollutants and cardiac autonomic function in a panel of healthy adults: a further analysis with existing data.INHALATION TOXICOLOGY,23(5),289-303.
MLA Wu, Shaowei,et al."The relationship between traffic-related air pollutants and cardiac autonomic function in a panel of healthy adults: a further analysis with existing data".INHALATION TOXICOLOGY 23.5(2011):289-303.
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