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学科主题: 公共卫生
题名:
The relationship between traffic-related air pollutants and cardiac autonomic function in a panel of healthy adults: a further analysis with existing data
作者: Wu, Shaowei1; Deng, Furong1; Niu, Jie2; Huang, Qinsheng2; Liu, Youcheng3; Guo, Xinbiao1
关键词: Air pollution ; carbon monoxide ; cardiac autonomic function ; heart rate variability ; panel study ; particulate matter
刊名: INHALATION TOXICOLOGY
发表日期: 2011-04-01
DOI: 10.3109/08958378.2011.568976
卷: 23, 期:5, 页:289-303
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
关键词[WOS]: HEART-RATE-VARIABILITY ; PARTICULATE MATTER ; METABOLIC SYNDROME ; CARBON-MONOXIDE ; POLLUTION ; EXPOSURE ; DISEASE ; ASSOCIATION ; MICE
英文摘要:

Context: Epidemiological studies have linked particulate matter (PM) and carbon monoxide (CO) exposures with alterations in cardiac autonomic function as measured by heart rate variability (HRV) in populations. Recently, we reported association of several HRV indices with marked changes in particulate air pollution around the Beijing 2008 Olympic Games in a panel of healthy adults.

Objective: We further investigated the cardiac effects of traffic-related air pollutants over wide exposure ranges with expanded data set in this panel of healthy adults.

Methods: We obtained real-time data on nine taxi drivers′ in-car exposures to PM <= 2.5 mu m in aerodynamic diameter (PM 2.5) and CO and on multiple HRV indices during a separate daily work shift in four study periods with dramatically changing air pollution levels around the Beijing 2008 Olympic Games. Mixed effect models and a loess smoother method were used to investigate the associations of exposures with HRV indices.

Results: Results showed overall negative associations of traffic-related air pollutants with HRV indices across periods, as well as differences in period-specific and individual associations. After stratifying the individuals into two different response groups (positive/negative), cardiac effects of air pollutants became stronger within each group. Exposure-response modeling identified changed curvilinear relationships between air pollution exposures and HRV indices with threshold effects.

Discussion and conclusion: Our results support the association of exposure to traffic-related air pollution with altered cardiac autonomic function in young healthy adults free of cardiovascular compromises. These results suggest a complicated mechanism that traffic-related air pollutants influence the cardiovascular system of healthy adults.

语种: 英语
所属项目编号: 2006BAI19B06 ; 81072267
项目资助者: National Key Technologies R&amp ; D Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000289797700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67498
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
3.Univ N Texas, Hlth Sci Ctr, Sch Publ Hlth, Dept Environm & Occupat Hlth Sci, Ft Worth, TX USA

Recommended Citation:
Wu, Shaowei,Deng, Furong,Niu, Jie,et al. The relationship between traffic-related air pollutants and cardiac autonomic function in a panel of healthy adults: a further analysis with existing data[J]. INHALATION TOXICOLOGY,2011,23(5):289-303.
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