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Quercetin But Not Quercitrin Ameliorates Tumor Necrosis Factor-Alpha-Induced Insulin Resistance in C2C12 Skeletal Muscle Cells
Dai, Xiaoqian; Ding, Ye; Zhang, Zhaofeng; Cai, Xiaxia; Bao, Lei; Li, Yong
关键词skeletal muscle cell insulin resistance quercetin inflammation AMP-activated protein kinase
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2013-05-01
36期:5页:788-795
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]ACTIVATED PROTEIN-KINASE ; NITRIC-OXIDE SYNTHASE ; NF-KAPPA-B ; GLUCOSE-UPTAKE ; INDUCED INFLAMMATION ; EXPRESSION ; RATS ; MECHANISMS ; INHIBITION ; TRANSPORT
英文摘要

Skeletal muscle is a major site for glucose metabolism and its injury by cytokines can induce insulin resistance leading to type 2 diabetes. It has been suggested that quercetin may act as an anti-diabetic agent, however, the effects of quercetin on insulin resistance in skeletal muscle remain unknown. We aimed to investigate the role of quercetin and its glycoside, quercitrin in tumor necrosis factor-alpha (TNF-alpha) induced C2C12 skeletal muscle cell impairment. Quercetin, but not quercitrin moderately attenuated the effects of TNF-alpha and enhanced the basal and insulin stimulated uptake of glucose in a dose-dependent manner via the activation of the protein kinase B (Akt) and AMP-activated protein kinase (AMPK) pathways. Furthermore, the underlying mechanism also involved the suppression of nuclear factor-kappa B (NF-kappa B) signaling and the nitric oxide (NO)/inducible nitric oxide synthase (iNOS) system, downstream of AMPK transduction. In summary, quercetin exhibited its effect of improving glucose uptake and insulin sensitivity in skeletal muscle cells via the two independent signaling pathways of Akt and AMPK, and can be developed as a potential anti-diabetic agent.

语种英语
WOS记录号WOS:000318331400016
项目编号H2603/81172652
资助机构National Natural Science Foundation of China (NSFC)
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67500
专题北京大学公共卫生学院
北京大学公共卫生学院_营养与食品卫生学系
作者单位Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China
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GB/T 7714
Dai, Xiaoqian,Ding, Ye,Zhang, Zhaofeng,et al. Quercetin But Not Quercitrin Ameliorates Tumor Necrosis Factor-Alpha-Induced Insulin Resistance in C2C12 Skeletal Muscle Cells[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2013,36(5):788-795.
APA Dai, Xiaoqian,Ding, Ye,Zhang, Zhaofeng,Cai, Xiaxia,Bao, Lei,&Li, Yong.(2013).Quercetin But Not Quercitrin Ameliorates Tumor Necrosis Factor-Alpha-Induced Insulin Resistance in C2C12 Skeletal Muscle Cells.BIOLOGICAL & PHARMACEUTICAL BULLETIN,36(5),788-795.
MLA Dai, Xiaoqian,et al."Quercetin But Not Quercitrin Ameliorates Tumor Necrosis Factor-Alpha-Induced Insulin Resistance in C2C12 Skeletal Muscle Cells".BIOLOGICAL & PHARMACEUTICAL BULLETIN 36.5(2013):788-795.
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