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Design and participant baseline characteristics of ′A Clinical Trial of IntensiVE Dialysis′: The ACTIVE Dialysis Study
Jardine, Meg J.1,4; Zuo, Li10; Gray, Nicholas A.6,7; De Zoysa, Janak11,12; Chan, Christopher T.13; Gallagher, Martin P.1,2; Howard, Kirsten3; Hertier, Stephane8; Cass, Alan1,9; Perkovic, Vlado1,5; ACTIVE Dialysis Steering Comm
关键词extended dialysis H(a)emodialysis left ventricular mass index quality of life randomized controlled trial
刊名NEPHROLOGY
2015-04-01
DOI10.1111/nep.12385
20期:4页:257-265
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]NOCTURNAL HOME HEMODIALYSIS ; QUALITY-OF-LIFE ; CONVENTIONAL HEMODIALYSIS ; FREQUENT HEMODIALYSIS ; PATIENT SURVIVAL ; DISEASE ; RISK ; LONG
英文摘要

AimsObservational reports suggest extended dialysis hours are associated with improved outcomes. These findings are confounded by better prognostic characteristics among people practising extended hours. The aim of this article is to provide an overview of the methods and baseline characteristics for ACTIVE Dialysis Study participants.

MethodsThis multicentre, randomized, open-label, blinded endpoint-assessment trial randomized participants receiving maintenance haemodialysis therapy to either extended (24h) or standard (12-18h) weekly haemodialysis for 12 months. A web-based randomization system used minimization to ensure balanced allocation across regions, dialysis setting and dialysis vintage. The primary outcome is the change in quality of life over 12 months of study treatment assessed by EQ-5D. Secondary outcomes include change in left ventricular mass index assessed by magnetic resonance imaging and safety outcomes including dialysis access events.

ResultsA total of 200 participants were recruited between 2009 and 2013 from Australia (29.0%), China (62.0%), Canada (5.5%) and New Zealand (3.5%). Participants had a mean age of 52 (12) years and 11.5% were dialysing at home, with a mean duration of 13.9h per week over a median of three sessions. At baseline, 32.5% had a history of cardiovascular disease and 36.5% had diabetes.

ConclusionThe ACTIVE Dialysis Study has met its planned recruitment target. The participant population are drawn from a range of health service settings in a global context. The study will contribute important evidence on the benefits and harms of extending weekly dialysis hours. The trial is registered at clinicaltrials.gov (NCT00649298).

Summary at a Glance This paper forms the background for the soon to be released ACTIVE Dialysis Study - an important study comparing quality of life in patients randomly assigned to conventional or extended hours haemodialysis.

语种英语
WOS记录号WOS:000352100800006
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67502
专题北京大学第二临床医学院_肾内科
作者单位1.George Inst Global Hlth, Sydney, NSW, Australia
2.Univ Sydney, Concord Clin Sch, Sydney Med Sch, Sydney, NSW 2006, Australia
3.Univ Sydney, Sch Publ Hlth, Sydney, NSW 2006, Australia
4.Concord Repatriat Gen Hosp, Renal Unit, Sydney, NSW, Australia
5.Royal N Shore Hosp, Dept Renal Med, Sydney, NSW, Australia
6.Nambour Gen Hosp, Renal Med, Nambour, Qld, Australia
7.Univ Queensland, Sunshine Coast Clin Sch, Nambour, Qld, Australia
8.Monash Univ, Sch Publ Hlth & Preventat Med, Melbourne, Vic 3004, Australia
9.Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT 0909, Australia
10.Peking Univ, Dept Nephrol, Peoples Hosp, Beijing 100871, Peoples R China
11.North Shore Hosp, Renal Serv, Westlake, New Zealand
12.Univ Auckland, Dept Med, Auckland, New Zealand
13.Univ Hlth Network, Div Med, Toronto, ON, Canada
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Jardine, Meg J.,Zuo, Li,Gray, Nicholas A.,et al. Design and participant baseline characteristics of ′A Clinical Trial of IntensiVE Dialysis′: The ACTIVE Dialysis Study[J]. NEPHROLOGY,2015,20(4):257-265.
APA Jardine, Meg J..,Zuo, Li.,Gray, Nicholas A..,De Zoysa, Janak.,Chan, Christopher T..,...&ACTIVE Dialysis Steering Comm.(2015).Design and participant baseline characteristics of ′A Clinical Trial of IntensiVE Dialysis′: The ACTIVE Dialysis Study.NEPHROLOGY,20(4),257-265.
MLA Jardine, Meg J.,et al."Design and participant baseline characteristics of ′A Clinical Trial of IntensiVE Dialysis′: The ACTIVE Dialysis Study".NEPHROLOGY 20.4(2015):257-265.
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