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学科主题临床医学
Immobilized heparin and its anti-coagulation effect on polysulfone membrane surface
Ren, Xiaoshuai1; Xu, Ling1,2; Xu, Jianxia3; Zhu, Peizhi1,4; Zuo, Li5; Wei, Shicheng1,6
关键词low temperature plasma hemodialysis polysulfone membrane heparin immobilization anti-coagulation
刊名JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
2013-10-01
DOI10.1080/09205063.2013.792643
24期:15页:1707-1720
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials ; Polymer Science
资助者State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities
研究领域[WOS]Engineering ; Materials Science ; Polymer Science
关键词[WOS]INDUCED THROMBOCYTOPENIA ; BLOOD COMPATIBILITY ; ULTRAFILTRATION MEMBRANES ; DIALYSIS MEMBRANE ; PLASMA TREATMENT ; HEMOCOMPATIBILITY ; CHITOSAN ; POLYURETHANES ; PERMEABILITY ; HEMODIALYSIS
英文摘要

Polysulfone has been widely used as hemodialysis membrane material because of its excellent physiochemical performance. There is still a need to further improve its anti-coagulation property in clinical practice. In this work, we covalently immobilized heparin onto polysulfone membrane to improve its anti-coagulation performance. Low temperature plasma technique with environmentally friendly nitrogen as the gas source, as well as N-ethyl-N ′-[3-dimethylaminopropy] carbodiimide hydrochloride/hydroxy-2,5-dioxopyrolidine-3-sulfonicacid sodium chemistry were utilized to immobilize heparin onto the surface of polysulfone membrane. X-ray photoelectron spectroscopy, attenuated total reflectance Fourier-transform infrared spectroscopy, as well as water contact angle results confirmed successful binding of heparin to the membrane surface. Only slight permeability differences were observed between the immobilized surface and the unmodified surface, while the polysulfone membrane had become more hydrophilic after immobilization. The blood coagulation time was greatly prolonged after modification and less platelets adhesion was observed on the heparin immobilized surface. Also, compared with heparin injection doses in clinical, the heparinized process in our work consumed less heparin. Our study suggests that the immobilized heparin has local anti-coagulation effect, while reducing the doses.

语种英语
所属项目编号2007CB936103
资助者State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities
WOS记录号WOS:000324365200001
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67508
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
2.Peking Univ, Coll Engn, Beijing Key Lab Solid Waste Utilizat & Management, Beijing 100871, Peoples R China
3.Natl Inst Food & Drug Control, Inst Med Devices Control, Beijing 100050, Peoples R China
4.Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
5.Peking Univ, Minist Hlth China, Key Lab Renal Dis, Renal Div,Dept Med,Inst Nephrol,Hosp 1, Beijing 100034, Peoples R China
6.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Ren, Xiaoshuai,Xu, Ling,Xu, Jianxia,et al. Immobilized heparin and its anti-coagulation effect on polysulfone membrane surface[J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,2013,24(15):1707-1720.
APA Ren, Xiaoshuai,Xu, Ling,Xu, Jianxia,Zhu, Peizhi,Zuo, Li,&Wei, Shicheng.(2013).Immobilized heparin and its anti-coagulation effect on polysulfone membrane surface.JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,24(15),1707-1720.
MLA Ren, Xiaoshuai,et al."Immobilized heparin and its anti-coagulation effect on polysulfone membrane surface".JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 24.15(2013):1707-1720.
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