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学科主题基础医学
Hyperpolarization-activated, cyclic nucleotide-gated cation channels: Roles in the differential electrophysiological properties of rat primary afferent neurons
Tu, HY; Deng, LB; Sun, Q; Yao, L; Han, JS; Wan, Y
关键词hyperpolarization-activated cyclic nucleotide-gated channel I-h dorsal root ganglion ZD7288
刊名JOURNAL OF NEUROSCIENCE RESEARCH
2004-06-01
DOI10.1002/jnr.20109
76期:5页:713-722
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]DORSAL-ROOT GANGLION ; CURRENT I-H ; PACEMAKER CHANNELS ; SYNAPTIC-TRANSMISSION ; SYMPATHETIC NEURONS ; SENSORY NEURONS ; HCN CHANNELS ; CURRENT I(H) ; SPINAL-CORD ; MODULATION
英文摘要

The large, medium-sized, and small neurons of the dorsal root ganglion (DRG) have different functions in the processing of various senses. Hyperpolarization-activated, cyclic nucleotide-gated channels (HCN) contribute greatly to neuronal excitability. In the present study, which used whole-cell patch clamp techniques and immunohistochemical staining methods, the electrophysiological properties of DRG neurons were systematically compared, and the roles of HCN-1, -2, and -4 were examined. The main results were as follows. 1) The large neurons had significantly higher V-0.5 values (membrane potential at which the HCN channels were half-activated) and shorter time constants (T) than small or medium-sized DRG neurons. However, large DRG neurons had higher I-h density (HCN neuron current). 2) HCN-1 was found predominantly, but not exclusively, in large and medium-sized DRG neurons; HCN-2 was found in all DRG neurons; and HCN-4 was poorly visualized in all DRG neurons. HCN-1 and HCN-2 were colocalized in large and medium-sized neurons with immunostaining of adjacent sections. In the dorsal horn of the spinal cord, HCN-1, HCN-2, and HCN-4 were all expressed in laminae I-IV, although HCN-1 was not detectable in lamina II. 3) Blockade of 1, current in DRG neurons caused a significant decrease in V0.5, resting membrane potential, and repetitive firing number of action potential and a significant increase in time of rising phase of action potential. These results suggest that the different HCN channels in the three types of DRG neurons might contribute to their differential electrophysiological properties. (C) 2004 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000221772700013
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被引频次:74[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67510
专题北京大学基础医学院_神经生物学系
作者单位Peking Univ, Neurosci Res Inst, Key Lab Neurosci, Minist Educ, Beijing 100083, Peoples R China
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Tu, HY,Deng, LB,Sun, Q,et al. Hyperpolarization-activated, cyclic nucleotide-gated cation channels: Roles in the differential electrophysiological properties of rat primary afferent neurons[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2004,76(5):713-722.
APA Tu, HY,Deng, LB,Sun, Q,Yao, L,Han, JS,&Wan, Y.(2004).Hyperpolarization-activated, cyclic nucleotide-gated cation channels: Roles in the differential electrophysiological properties of rat primary afferent neurons.JOURNAL OF NEUROSCIENCE RESEARCH,76(5),713-722.
MLA Tu, HY,et al."Hyperpolarization-activated, cyclic nucleotide-gated cation channels: Roles in the differential electrophysiological properties of rat primary afferent neurons".JOURNAL OF NEUROSCIENCE RESEARCH 76.5(2004):713-722.
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