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学科主题: 基础医学
题名:
Solution conformation study on a beta-turn forming peptide
作者: Gao, F; Sha, YL; Qiu, Y; Wang, YF; Li, YL; Lai, LH; Wu, HM
关键词: beta-turn ; CD ; FT-IR ; NMR ; peptide
刊名: ACTA PHYSICO-CHIMICA SINICA
发表日期: 2001-07-01
DOI: 10.3866/PKU.WHXB20010709
卷: 17, 期:7, 页:619-621
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Physical
研究领域[WOS]: Chemistry
关键词[WOS]: SHORT LINEAR PEPTIDE ; HAIRPIN ; FOLDS
英文摘要:

The model six-residue linear peptide AAGDYY-NH2 from TEM-1 beta -lactamase inhibitor protein and BLIP was predicted to adopt a beta -turn conformation and synthesized in order to elucidate the mechanism of beta -turn formation and stability. Its structural preferences in solution were comprehensively characterized using CD (circular dichroism), FT-IR and H-1-NMR spectroscopy. The set of observed short- and medium-range NOEs, the restrained molecular dynamics simulation, CD and FT-IR spectroscopy were consistent with the formation of beta -turn in solution by the model peptide. The results implicate beta -turn playing an important role in the process of protein folding.

语种: 中文
WOS记录号: WOS:000170070000009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67512
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Peking Univ, Coll Chem & Mol Engn, Inst Phys Chem, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Biophys, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

Recommended Citation:
Gao, F,Sha, YL,Qiu, Y,et al. Solution conformation study on a beta-turn forming peptide[J]. ACTA PHYSICO-CHIMICA SINICA,2001,17(7):619-621.
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