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学科主题: 临床医学
题名:
Changes in total sodium intake do not lead to proportionate changes in total sodium removal in CAPD patients
作者: Cheng, LT; Wang, T
关键词: fluid status ; sodium autoregulation ; dietary salt intake
刊名: PERITONEAL DIALYSIS INTERNATIONAL
发表日期: 2006-03-01
卷: 26, 期:2, 页:218-223
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: PERITONEAL-DIALYSIS PATIENTS ; RENAL-FAILURE ; CONSERVING ABILITY ; ADAPTATION ; DISEASE ; DOGS
英文摘要:

Background: Dietary salt and fluid restriction is important in controlling fluid balance in patients on continuous ambulatory peritoneal dialysis (CAPD). However, it is often difficult to monitor patients′ dietary total sodium intake (TSI). Usually, total sodium removal (TSR), the sum of urinary sodium removal (USR) and dialysate sodium removal (DSR), is suggested to represent TSI. In the present study, we investigated the reliability of using TSR as a surrogate to TSI in CAPD patients.

Methods: 40 clinically stable CAPD patients were closely followed for 3 months. Their TSI, USR, DSR, and fluid status were measured twice: at baseline and at the end of this study respectively. Fluid status was evaluated by bioimpedance analysis. Patients with increased sodium intake (group ISI) or decreased sodium intake (group DSI) (both > 0.5 g/day or > 21.74 mmol/day elemental sodium) were included in this study.

Results: There were 15 patients in group ISI and 9 patients in group DSI. During the follow-up, although TSI increased in group ISI and decreased in group DSI (p < 0.05), there were no significant changes in USR, DSR, or TSR in either group. No relationship was found between TSI and TSR. Changes in weight, blood pressure, urine volume, ultra filtration, and small solute removal (Kt/V and creatinine clearance) were not statistically significant between the two groups. Fluid status deteriorated in group ISI and improved in group DSI (p < 0.05).

Conclusions: Our study suggests that changes in total sodium intake do not lead to proportionate changes in total sodium removal in CAPD patients. Therefore, TSR (the sum of USR and DSR) should be used cautiously to monitor TSI in this patient population.

语种: 英语
WOS记录号: WOS:000237003600018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67517
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: Peking Univ, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China

Recommended Citation:
Cheng, LT,Wang, T. Changes in total sodium intake do not lead to proportionate changes in total sodium removal in CAPD patients[J]. PERITONEAL DIALYSIS INTERNATIONAL,2006,26(2):218-223.
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